[PDF] Top 20 Replication landscape of the human genome
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Replication landscape of the human genome
... size of most AS was striking, with only a few tens o10 kb, suggesting that replication initiates mostly within broad zones and questioning whether site-specific origins exist in the human ... Voir le document complet
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Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.
... At the end of the labeling period, cells were harvested by trypsinisation, centrifuged at 500 g for 10 min at 4uC, washed in ice-cold 16PBS, centrifuged again and fixed in 80% ethanol in 16 ...PBS. ... Voir le document complet
23
FORK-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing
... compared the resulting replication fork directionality (RFD) pro- files with independent RFD profiles generated by sequencing purified Okazaki fragments [ 14 , 22 ...replicates of the ... Voir le document complet
26
Whole-genome fingerprint of the DNA methylome during human B cell differentiation
... Analysis of the DNA methylome of different B-cell subpopulations by WGBS and ...Description of the B-cell subpopulations and techniques used in this ...(PCA) of WGBS data ... Voir le document complet
38
Bacterial infection remodels the DNA methylation landscape of human dendritic cells
... to the cutoffs used to call MTB-DMRs (Supplemental ...despite the fact that the mechanisms controlling active and passive chang- es in methylation are markedly different (Kohli and Zhang ... Voir le document complet
13
DNA replication timing data corroborate in silico human replication origin predictions
... DNA replication is a crucial cellular process responsible for robust and accurate transmission of genetic information through successive cell ...nomes of bacteria and viruses replicate as a single ... Voir le document complet
4
3D Chromosome Regulatory Landscape of Human Pluripotent Cells
... in the human genome (Dunham et ...and the constraints that cause them to operate only on their specific target genes are not fully understood (Zabidi et ...in the context of 3D ... Voir le document complet
26
Quantification of GC-biased gene conversion in the human genome
... analyses of DAF spectra indicate that the strength of gBGC is very similar at CpG and non-CpG sites ...study of NCO recombination events in human pedigrees, which revealed the ... Voir le document complet
15
Knockdown of human AMPK using the CRISPR-Cas9 genome-editing system
... 9. Wu YH, Li Q, Li P, Liu B (2016) GSK621 activates AMPK signaling to inhibit LPS- induced TNFalpha production. Biochem Biophys Res Commun 480 (3):289-295. 10. Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier ... Voir le document complet
30
Draft genome sequence of Fermentimonas caenicola strain SIT8, isolated from the human gut
... caenicola, Genome, Human gut, Microbiota Introduction Fermentimonas caenicola strain SIT8 (= CSUR P1560) was isolated from the stool of a healthy 28-month-old Senegalese boy as part of ... Voir le document complet
9
Investigating the function of histone H2A.Z in the human genome and mechanisms of chromatin incorporation
... Introduction The regulation of chromatin dynamics is a key mechanism that controls essential cellular functions such as gene expression, DNA repair, and replication (Voss and Hager, ...modification ... Voir le document complet
224
Transcription-coupled TA and GC strand asymmetries in the human genome
... if the transversion rates were also modi¢ed. We thus supposed the existence of an additional transcription-coupled process leading to ...to the largest strand asymmetry [19] ...lower ... Voir le document complet
4
Structural variations of the human genome and transcriptome induced by LINE-1 retrotransposons
... that the 40S ribosome subunit binds to the m7G cap at the 5‘ end of the transcript, followed by linear scanning until the first AUG in the appropriate Kozak initiation ... Voir le document complet
195
An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles
... explains the correlations between origins evolutionary events. Result of the joint model best- fitting simulation compared with empirical ...for the ten Lachancea species (red ...diamonds). ... Voir le document complet
41
Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture
... providing the RPE1 Xa somatic cell hybrid; Christine Disteche for providing the Patski cell line; Feng Zhang for use of pX458; and Sigrid Knemeyer for assistance with the design and ... Voir le document complet
10
Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm
... DNA replication program in a cell is defined as the tempo- ral sequence of locus replication events during the S ...phase. The program depends on the locations of ... Voir le document complet
14
The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability
... auto-SUMOylation of SLX4 is also greatly impacted by mutations in the BTB domain suggesting that the BTB domain does not only play a role in XPF ...Since the BTB domain also mediates SLX4 ... Voir le document complet
56
Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
... Expression of FMRP, but Not the FMRP-I304N Mutant, Reduces RLFS-Induced DSBs To test whether FMRP prevents R-loop formation, we used a modified yeast-based recombination assay ( Prado and Aguilera, 2005 ) ... Voir le document complet
26
Genomic landscape of human diversity across Madagascar
... using the fineSTRUCTURE approach (26). The first step of this method (ChromoPainter) examines each segment of the autosomal genome of one individual and determines which ... Voir le document complet
10
Genome-wide binding map of the HIV-1 Tat protein to the human genome
... cell, the HIV-1 genome is reverse- transcribed and the proviral DNA is integrated into the host ...Subsequently, the HIV-1 provirus is transcribed allowing assembly and release ... Voir le document complet
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