[PDF] Top 20 The RAS‐related GTPase RHOB confers resistance to EGFR‐tyrosine kinase inhibitors in non‐small‐cell lung cancer via an AKT‐dependent mechanism
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The RAS‐related GTPase RHOB confers resistance to EGFR‐tyrosine kinase inhibitors in non‐small‐cell lung cancer via an AKT‐dependent mechanism
... is the main oncogenic driver in non-small-cell lung cancer (NSCLC), occurring in 10 –50% of the patients depending on their ...origins. ... Voir le document complet
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The RAS ‐related GTP ase RHOB confers resistance to EGFR ‐tyrosine kinase inhibitors in non‐small‐cell lung cancer via an AKT ‐dependent mechanism
... is the main oncogenic driver in non-small-cell lung cancer (NSCLC), occurring in 10 –50% of the patients depending on their ...origins. ... Voir le document complet
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en fr Identification and vectorization of combination of drugs for the treatment of lung tumors resistant to EGFR tyrosine kinase inhibitors Identification et vectorisation de combinaisons de traitements pour la thérapie des tumeurs pulmonaires résistantes aux inhibiteurs de tyrosine kinase de l'EGFR
... Although the use of new therapeutic agents has improved the treatment of cancer patients in recent years, the efficacy of targeted therapies is limited by the development of drug ... Voir le document complet
251
Implicating the mechanisms of ADP-ribosylation factor activation in the resistance of invasive breast cancer cells to EGFR tyrosine kinase inhibitors
... demonstrated to be up-regulated by steroid hormones in differentiated hormone-sensitive cancer cells and elevated in the highly invasive breast cancer MDA-MB-231 cell ... Voir le document complet
270
Anti-EGFR monoclonal antibodies and EGFR tyrosine kinase inhibitors as combination therapy for triple-negative breast cancer
... expressed in MDA-MB-468 cells, five genes involved in cell cycle progression (CCNA1, CCNB1, CCND1, CCNE1, CHEK1) were down-regulated by anti-EGFR ...that the combination of mAbs and ... Voir le document complet
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The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism
... overexpressed in nonsmall-cell lung cancers (NSCLCs) and is associated with a poor ...targeting the tyrosine kinase activity of EGFR (EGFR- TKIs, such as gefitinib ... Voir le document complet
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RhoB loss induces Rac1-dependent mesenchymal cell invasion in lung cells through PP2A inhibition
... 5. RhoB regulates PP2A activity by modulating its interaction with the B55 regulatory ...against the B55 regulatory subunit of PP2A (siB55). The phosphorylation state of Akt on S473 and ... Voir le document complet
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The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac.
... containing the start codon of human Fer (5’-ggggatccatggggtttgggagtgacctg) was used to introduce a BamHI site immediately 5’ to the Fer ...and the 5’ BamHI- NsiI fragment ligated with a ... Voir le document complet
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An Atypical Kinase under Balancing Selection Confers Broad-Spectrum Disease Resistance in Arabidopsis
... RKS1 confers broad-spectrum resistance to Xc In the literature, broad-spectrum resistance refers in general to ‘‘resistance to multiple isolates/races ... Voir le document complet
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Pemetrexed Hinders Translation Inhibition upon Low Glucose in Non-Small Cell Lung Cancer Cells
... 4.2. Cell Extracts and Western Blot Analysis To perform Western blot analysis, A549 cells were seeded onto 6-well plates ...Whole cell extracts were prepared from cultured cells lysed in RIPA ... Voir le document complet
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CRISPR-mediated interrogation of small cell lung cancer
... 170 In this thesis, I have utilized the CRISPR-Cas9 system in two complementary ways to advance our understanding of the molecular mechanisms involved in SCLC initiation, ... Voir le document complet
220
Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility
... a small Ras-like GTPase; Mutual gliding motility B (MglB), its GTPase activating protein (GAP); and Required for Motility Response Regulator (RomR), a protein that contains a response ... Voir le document complet
31
The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner
... GTPase activity [ 17 , 18 , 24 ]. This study is the first to demonstrate the direct role of a p53 isoform in regulating the activity of a Rho ...of the Rho group of ... Voir le document complet
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Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer
... was to determine the diagnostic potential of the ISET method for preoperative detection of CTC in resectable NSCLC patients and to correlate the presence and number of CTCs with ... Voir le document complet
130
Amphiregulin promotes BAX inhibition and resistance to gefitinib in non-small-cell lung cancers.: Areg and gefitinib resistance in NSCLC
... In addition to being a potential biomarker, Areg might also be a therapeutic target, especially in ...growth in vivo. SiRNAs-based treatments in vivo are usually poorly efficient, ... Voir le document complet
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Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer
... and the transcriptional regulator complex ...*within the NLS three short regions act as a nucleolar targeting signal (NTS); REASP—binding motif; PHD—plant homeodomain; PBR—polybasic ...according to ... Voir le document complet
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Rôle de la GTPase RhoB dans l'oncogenèse pulmonaire
... carcinome in situ, les cellules tumorales vont subir de nouvelles modifications qui leur permettent alors de se détacher de la tumeur primaire, de traverser la membrane basale sous-jacente et d’envahir le tissu ... Voir le document complet
197
Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme
... unchanged in control versus gefitinib-treated TGFα-EGFR WT ;InkΔ2/3 −/− tumor cells (Supplementary Figure ...from the gene profiling data failed to identify apoptosis-specific signature ... Voir le document complet
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A single amino acid substitution (H451Y) in Leishmania calcium-dependent kinase SCAMK confers high tolerance and resistance to antimony
... resuspended in fresh medium. The integrity of genomic DNA extracted from Lm_ctrl and Lm_H451Y cultures exposed to 20, 40 or 80 µM miltefosine for three days was analysed as described in ... Voir le document complet
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Developmental Modulation of Root Cell Wall Architecture Confers Resistance to an Oomycete Pathogen
... accumulated in micro-colonies be- tween cells of the root nodule primordia ( Figure 2 ...A). To identify the genetic basis of the observed cell entry pheno- types, we combined ... Voir le document complet
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