[PDF] Top 20 Regional and cellular gene expression changes in human Huntington's disease brain
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Regional and cellular gene expression changes in human Huntington's disease brain
... Revised and Accepted February 1, 2006 Huntington’s disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the ... Voir le document complet
13
Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain
... found in the brain, human brain tissue cannot be used to measure molecular biomarkers to monitor disease state and pro- gression in living ...ubiquitous expression ... Voir le document complet
14
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
... categories and human HD. The present study focuses on the gene expression in the stria- tum, the HD brain region demonstrating both the most dra- matic neuropathology and ... Voir le document complet
17
Regional methylation of the 5 end CpG island of BRCA1 is associated with reduced gene expression in human somatic cells
... suppressor gene (2). Indeed, in breast cancers linked to BRCA1, as expected for a tumor suppressor gene, allelic deletions at this locus invariably involve the wild-type allele (3, ...involvement ... Voir le document complet
11
Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures
... Signatures and Their Relevance to Transcriptional Reprogramming in HD Previous studies have investigated cell-type-specific transcrip- tomic signatures in the mouse striatum ( Gokce et ...diversity ... Voir le document complet
38
Expression analysis of novel striatal-enriched genes in Huntington disease
... Revised and Accepted November 18, 2009 Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease ...unknown. Expression studies of diseased human ... Voir le document complet
14
Lipotoxic injury differentially regulates brain microvascular gene expression in male mice
... transcriptome changes in response to the WD in the hippocampal microvasculature of male mice including the modulation of protein-coding genes, miRNAs, snoRNAs, and lncRNAs, as well as the ... Voir le document complet
27
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis
... Revised and Accepted January 18, 2010 Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in ... Voir le document complet
15
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
... (AP-1) and nuclear factor kB (NF-kB) were markedly enriched in the promoters of genes in APOE module (Figure ...enriched in DEGs affected by APOE4 in all of induced brain cell ... Voir le document complet
34
Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain
... essential brain lipid, ensures proper neuronal development and function, as demonstrated by links between perturbations of cholesterol metabolism and neurodegenerative diseases, including Alzheimer’s ... Voir le document complet
16
Exploring the dynamic changes between pulmonary and cutaneous sarcoidosis based on gene expression
... F_PSC and SL_PSC, indicating that these biological processes play significant roles in the fibrotic progress of ...role in granuloma formation and maintenance [26, 34] ...lymphocytes ... Voir le document complet
12
Development of cellular and gene therapies for b[beta]-Thalassemia and sickle cell disease
... The author and co-authors if applicable retain copyright ownership and moral rights in this document. Neither the whole thesis or dissertation, nor substantial extracts from it, may be printed or ... Voir le document complet
340
Gene Expression Changes and Community Turnover Differentially Shape the Global Ocean Metatranscriptome
... Patterns and drivers of global ocean microbiome compositions across depth layers, and between polar and non-polar ...metagenomic, and metatranscriptomic composition of epipelagic samples ... Voir le document complet
61
Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice.
... hemispheres) and P5 (one hemisphere) and reverse transcribed (n = 3 per experimental ...) and trimming of adaptor sequences was performed using Trim Galore! version ...2.1.0 and aligned reads ... Voir le document complet
15
The human cumulus--oocyte complex gene-expression profile.
... (ERBB4), and a frizzled receptors (FZD3) member of the WNT pathway. In addition we observed 6 poorly characterized G protein-coupled receptors in oocytes (GPR37, GPR39, GPR51, GPR126, GPR143, ... Voir le document complet
44
Do changes in gene expression contribute to sexual isolation and reinforcement in the house mouse?
... deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...teaching and research institutions in France or abroad, or from public or private research ... Voir le document complet
54
Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRI
... present in a wide range of other parkinsonian conditions such as progressive supranuclear palsy, dementia with Lewy bodies, and multiple system ...by disease progression and the response of ... Voir le document complet
4
Hypoxia-inducible factor (HIF1α) gene expression in human shock states.
... expression may be more accurate in tissue than in ...performed in a short time. Our study was aimed at providing an early marker in real-life clinical ...hypoxia in sepsis ... Voir le document complet
7
Functional expression of a human TCRβ gene in transgenic mice
... Although it has been shown in Tcrb transgenic scidlscid mice (8,34) that TCR/3 chains can appear on thymocytes at early stages of differentiation together with an as yet non-characterize[r] ... Voir le document complet
7
Cellular and molecular aspects of cell therapy in mouse models of Parkinson's disease and traumatic brain injury
... 6 Netrin-1, suggérant un rôle pour la Netrin-1 dans la formation de la voie dopaminergique pendant le développement (Xu et al., 2010). Grâce au même type d’approche de neuroanatomie, nous avons également montré que ... Voir le document complet
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