Haut PDF Radiopharmaceutical dosimetry in targeted radionuclide therapy
Radiopharmaceutical dosimetry in targeted radionuclide therapy
... of dosimetry for this treatment. In the case of hyperthyroidism, the case of the European Association of Nuclear Medicine (EANM) guidelines recommend prescribing different absorbed doses depending on the ...
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Multi-scale dosimetry for targeted radionuclide therapy optimisation
... distribution in the LR–SS model coincided with the bladder ...described in section 5.2.3 was implemented in order to achieve reasonable simulation times for the HR–SS ...module in Geant4 and ...
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Impact of Mouse Model on Pre-Clinical Dosimetry in Targeted Radionuclide Therapy
... micro-SPECT/CT). In that context, the relevance of model-based dosimetry may have to be reconsidered: If cumulated activities can be obtained for a given animal, then on principle the absorbed dose should ...
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Theranostic Approach for Metastatic Pigmented Melanoma Using ICF15002, a Multimodal Radiotracer for Both PET Imaging and Targeted Radionuclide Therapy
... characterized in murine and human melanoma models by both in vivo PET imaging and ex vivo ...studies in melanoma-bearing mice demonstrated an early and high tumor accumulation of [ 18 F]ICF15002, as ...
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![Implementation of patient dosimetry in the clinical practice after targeted radiotherapy using [177Lu-[DOTA0, Tyr3]-octreotate](https://thumb-eu.123doks.com/thumbv2/123doknet/14208748.481516/cover.webp)
Implementation of patient dosimetry in the clinical practice after targeted radiotherapy using [177Lu-[DOTA0, Tyr3]-octreotate
... tions in peptide pharmacokinetics require treatment individualization by tailoring the number of cycles or the administered activity [ 11 ...]. In this context, therapy plan- ning based on the ...
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A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications
... 2 In radiation therapy (RT), treatment plan- ning requires an accurate assessment of the absorbed dose distribution throughout the organs and tissues of ...and targeted radionuclide ...
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en fr Development of a new anti-cancer agent for targeted radionuclide therapy : ß- radiolabeled RAFT-RGD. Le RAFT-RGD radiomarqué avec un émetteur °- comme nouvel agent de radiothérapie interne vectorisée
... 26 Les effets particuliers des faibles doses (inférieures à 0,2 Gy) o Effet de proximité La radiosensibilité d’une cellule peut être augmentée ou diminuée du fait de ses interactions avec les cellules voisines, soit ...
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Synthesis of lutetium-carrying oligonucleotides for targeted cancer therapy and imaging
... cancer therapy there is need for targeted treatment that kills tumour cells selectively while minimizing damage to healthy ...cells. In this regard, specific targeting of tumours through ...
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Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
... Thermo Fisher Scientific, UK; pH 7.4), quenched with 1% hydrogen peroxide (Sigma Aldrich, UK) in methanol and blocked in 10% normal goat serum for VCAM-1 expression or normal horse serum for CD31. Primary ...
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Introduction to Radiobiology of Targeted Radionuclide Therapy
... observed in EBRT also after high absorbed dose (10 ...are in contact and the molecules are small (<1500 Da) (Figure 1),or by the release of sol- uble damage/stress signals that may have distant ...
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Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
... only in the R14del mutation with the parent clone ...the targeted gene correction did not alter the gene expression level of PLN and appropriate expression of the ‘TALEN-corrected’ allele was confirmed ...
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First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK
... (TIAC) in each selected ...first in the heads of both femora and the second in the lumbar vertebrae ...occurred in the red marrow was obtained by averaging the number of disintegration per ...
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Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy
... resulting in increased receptor ...resulted in a higher uptake of the conjugate in receptor- expressing cells in comparison with the complex ...overexpressed in various kinds of ...
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Pan Aurora Kinase Inhibitor: A Promising Targeted-Therapy in Dedifferentiated Liposarcomas With Differential Efficiency Depending on Sarcoma Molecular Profile
... regarding in vitro drug response. In some cell-lines, the high response at low doses, compared to doxorubicin, is a good indicator to test AMG 900 as ...observed in other STS cell-lines when combined ...
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Multichannel OSL dosimetry for dose verification in radiotherapy
... is in the red part of the visible spectrum. The corresponding absorption in silica fibres is ~10 dB/km enabling remote operation up to several hundreds of ...is in the blue part of the visible ...
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The IRS Fricke dosimetry system
... shown in Figure ...change in % transmittance, so the sample holder is not ...stored in the spring that when the motor tries to move the sample transport accessory by 1 step, the torque produced ...
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Radionuclide distribution in tidal flat sediments of the Westerschelde estuary
... the Molenplaat stations, based on organic carbon content and sedimentation rates of the sediment cores, vary between 10 and 105 gC m" 2 y\ which is about 30 - 40 % of the total yea[r] ...
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Fiber-Coupled, Time-Gated Al$_2$O$_3$:C Radioluminescence Dosimetry Technique and Algorithm for Radiation Therapy With LINACs
... real-time In Vivo Dosimetry (IVD) based on Radioluminescence (RL) of dosimetric- grade Al2O3:C crystals is described and demonstrated in reference conditions with 12-MV photon beams from a Saturne 43 ...
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Targeted photoredox catalysis in cancer cells
... well in 96-well plates (Costar) at 310 K in a 5% CO 2 /95% air incubator (Thermo) for 24 ...irradiated in phenol red-free cell culture medium under normoxia (20% O 2 , 465 nm, light dose ...h ...
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Effects of radionuclide contamination on leaf litter decomposition in the Chernobyl exclusion zone
... and DNA damage decreased in wild birds exposed to chronic low-dose radiation at CEZ. They concluded that birds may adapt to chronic expo- sure to ionizing radiation with a hormetic response. (ii) Because we used ...
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