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[PDF] Top 20 Proprotein convertase subtilisin/kexin type 9 in human disease

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Proprotein convertase subtilisin/kexin type 9 in human disease

Proprotein convertase subtilisin/kexin type 9 in human disease

... as in FH (Alrasadi et al ...commonly in renal failure (Moe et al 2004), followed by uncontrolled diabetes, aggressive smoking and hypercholesterolemic disorders (Shao et al ...occurs in rare ... Voir le document complet

149

Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9

Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9

... Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in plasma cholesterol regulation through modu- lation of low density lipoprotein receptor ... Voir le document complet

17

Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia

Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia

... that in addition to its effect on LDL-cholesterol, PCSK9 deficiency might protect against cardiovascular disease by reducing postprandial ...affecting proprotein conver- tase ... Voir le document complet

8

Letter From Le May and Cariou Regarding Article, "Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor-Dependent and -Independent

Letter From Le May and Cariou Regarding Article, "Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor-Dependent and -Independent Mechanisms"

... Circulation in which they studied the physiological role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in intestinal triglyceride- rich lipoprotein ... Voir le document complet

3

Régulation de la proprotéine convertase subtilisine / kexine type 9 (PCSK9) dans les cellules intestinales Caco-2/15

Régulation de la proprotéine convertase subtilisine / kexine type 9 (PCSK9) dans les cellules intestinales Caco-2/15

... ABSTRACT Proprotein convertase subtilisin/kexin type 9 (PCSK9) posttranslationally promotes the degradation of the low-density lipoprotein receptor (LDLr) in hepatocytes ... Voir le document complet

138

Preventing and treating kidney disease in patients with type 2 diabetes

Preventing and treating kidney disease in patients with type 2 diabetes

... endpoints in patients with ...renal disease progression [ 70 ] and accumulating evidence indicates that their antiprotei- nuric effect correlates with their additional renal benefits [ 71 ...reduction ... Voir le document complet

19

The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease

The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease

... involved in the detoxification of xenobiotics and biotransformation of endogenous ...variants in genes that encode EHs and are involved in multiple disorders, in light of large datasets that ... Voir le document complet

18

Dysregulated microRNA expression in human osteoclasts and Paget’s disease of bone

Dysregulated microRNA expression in human osteoclasts and Paget’s disease of bone

... miRNA In order to evaluate the levels of miRNA in pagetic OC, and preliminarily determine potentially differentially expressed miRNA, a discovery cohort was executed using deep ...miR in the OCs ... Voir le document complet

103

L’implication de la proprotéine convertase PACE4 dans le cancer du sein

L’implication de la proprotéine convertase PACE4 dans le cancer du sein

... indirect fashion following a long term exposure. Nonetheless our data is consistent with the absence of ER response elements in the PACE4 promoter. Despite the limitation of using a single cell line, the use of ... Voir le document complet

73

Plasma Type I IFN Protein Concentrations in Human Tuberculosis

Plasma Type I IFN Protein Concentrations in Human Tuberculosis

... Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, 4 Université Paris Descartes & AP-HP, Groupe Hospitalier Universitaire Paris Centre, Service de Virologie, Paris, ... Voir le document complet

6

Nucleotide substrate binding characterization in human pancreatic-type ribonucleases

Nucleotide substrate binding characterization in human pancreatic-type ribonucleases

... canonical human pancreatic-type RNases, identified in the initial sequencing of the human genome, perform distinct biological functions such as anti-pathoge- nicity, angiogenesis and host ... Voir le document complet

25

Presence of Oestrogen Receptor Type Beta in Human Retina

Presence of Oestrogen Receptor Type Beta in Human Retina

... EXPRESSION IN THE POSTERIOR SEGMENT The primer specificity was checked using total RNA isolated from human testis and from endometrial Ishikawa cells and breast adeno- carcinoma MCF-7 cells (data not ... Voir le document complet

6

Étude du mécanisme de régulation génique de la convertase furine lors de la différenciation des mégakaryocytes et implications proposées de cette convertase dans le processus de coagulation sanguine

Étude du mécanisme de régulation génique de la convertase furine lors de la différenciation des mégakaryocytes et implications proposées de cette convertase dans le processus de coagulation sanguine

... les plaquettes permettent le transport et le relâchement de protéines favorisant l'amplifieation du processus de coagulation (granules denses) et de facteurs de eroissance impli[r] ... Voir le document complet

255

Single-cell gene profiling of human regulatory T cell subsets in human graft-versus-host disease

Single-cell gene profiling of human regulatory T cell subsets in human graft-versus-host disease

... of human regulatory T cell subsets in human graft-versus-host disease Shen Dong 1* , Sylvie Maiella 1 , Aliénor Xhaard 2 , Yuanyu Pang 1 , Christophe Becavin 3 , Arndt Benecke 3 , Gérard Socié ... Voir le document complet

2

CNS disease models with human pluripotent stem cells in the CRISPR age

CNS disease models with human pluripotent stem cells in the CRISPR age

... lactate). In order to avoid these one must limit the greatest distance between a cell and the ...cultures in Boyden chambers, exposed to medium from both apical and basal side, can remain viable for months ... Voir le document complet

13

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.

... present in the hippocampus of human controls and AD patients (five age-matched controls + five AD Braak 6/Thal 5 patients) and in APP/ PS1ΔE9 transgenic mice ...[31]. Human APP content was ... Voir le document complet

18

Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas

Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas

... A375 human melanoma tumor uptake of 111 In-DOTA-F3B aptamer compared to the 111 In-DOTA-control-sequence was confirmed ex vivo by autoradiography and by scinti- graphic ...if human tumor cell ... Voir le document complet

17

PD01 - Respiratory allergens in human milk: potential impact on susceptibility to allergic airway disease

PD01 - Respiratory allergens in human milk: potential impact on susceptibility to allergic airway disease

... the human situation shows early life expo- sure to Der p through milk primes the immune ...allergens in breast-milk may be an important factor in driving the early immune function towards allergic ... Voir le document complet

2

TLR3 promotes MMP-9 production in primary human airway epithelial cells through Wnt/beta-catenin signaling.

TLR3 promotes MMP-9 production in primary human airway epithelial cells through Wnt/beta-catenin signaling.

... junctions in AEC were then investigated by fluorescent ...cultured in TGF-β and poly(I:C). The transfer of the active form of β-catenin in the nucleus was confirmed by subcellular fractionation ... Voir le document complet

11

Altered expression of type I insulin-like growth factor receptor in Crohn's disease

Altered expression of type I insulin-like growth factor receptor in Crohn's disease

... increase in absolute number of IGF-1R positive IC in lamina propria and submucosa of CD was parallel to the increase of the immunoinflammatory ...increase in the proportion (relative numbers) of IC ... Voir le document complet

9

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