[PDF] Top 20 Prophylactic donor lymphocyte infusion in patients with high-risk acute myeloid leukemia: ready for prime time?
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Prophylactic donor lymphocyte infusion in patients with high-risk acute myeloid leukemia: ready for prime time?
... of prophylactic DLI in patients with high-risk acute leukemia has been reported by Liga et ...ago. In that study, patients were given allo-HCT ... Voir le document complet
3
The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years—a report from the EBMT acute leukemia working party
... of acute and chronic GVHD, NRM, and disease relapse incidence ...Start time was the date of trans- plant for all ...death with- out ...NRM in a compet- ing risk setting, because ... Voir le document complet
15
Influence of alternative donor type on early survival after hematopoietic stem cell transplantation for acute myeloid leukemia lacking a sibling donor
... transplant in this group. We might have observed a better OS for the haplo group if haploidentical transplant had been used systematically in first ...conducted with unmanipulated grafts and ... Voir le document complet
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Inferior outcome of allogeneic stem cell transplantation for secondary acute myeloid leukemia in first complete remission as compared to de novo acute myeloid leukemia
... classical risk factors, i.e., cytogenetics and age, as well as donor type, our data identify sAML as an independent intrinsic factor for inferior outcome after alloSCT in ...associated ... Voir le document complet
10
Post-remission strategies for the prevention of relapse following allogeneic hematopoietic cell transplantation for high-risk acute myeloid leukemia: expert review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
... AML risk pro file and stage and the pre- sence or absence of minimal residual disease (MRD) [ 1 – 3 ...accounts for ~ 40% of treatment failures, with a preponderance of failures occurring in ... Voir le document complet
12
Prophylactic donor lymphocyte infusion after allogeneic stem cell transplantation in acute leukaemia - a matched pair analysis by the Acute Leukaemia Working Party of EBMT.
... Strategies for relapse prevention after allogeneic transplantation in acute leukaemia are ...phylactic donor lymphocyte infusion ...proDLI in com- plete remission (CR) and ... Voir le document complet
6
The stem cell mobilizing capacity of patients with acute myeloid leukemia in complete remission correlates with relapse risk: results of the EORTC-GIMEMA AML-10 trial
... present in the graft result in a higher relapse risk after ...unlikely for several ...between patients in the high CD34 + yield and the low CD34 + yield ...relapse ... Voir le document complet
8
Outcome and impact of post-remission strategy after MIDAM regimen in patients with relapsing or refractory acute myeloid leukemia
... ment with bortezomib and dexamethasone (VD) was immediately ini- ...cycles with additional 2 cycles of hyperCVAD-VD (hyper-fractionated cyclophosphamide, vincristine, doxorubicin, ...ASCT with a ... Voir le document complet
4
H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations
... cells in culture and (ii) wide availability of cell lines representing the heterogeneity of ...changes in culture; (ii) no longer retain tumour heterogeneity that was previously present in the ... Voir le document complet
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Sequential Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Intermediate or High-Risk Acute Myeloid Leukemia in Complete Remission: a Study From the ALWP of the EBMT
... archive for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...institutions in France or abroad, or from public or private research ... Voir le document complet
22
Impact of physicians' characteristics on decision making in elderly acute myeloid leukemia
... elderly acute myeloid leukemia(AML) patients (pts) are ...heterogeneity in clinical practice which is still poorly ...the patients’ determinants of care but very few have ... Voir le document complet
2
Intravenous busulfan for autologous stem cell transplantation in adult patients with acute myeloid leukemia: a survey of 952 patients on behalf of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
... AML patients undergoing intravenous busulfan-based conditioning prior to ASCT from January 2003 to December 2011 were reported to the Acute Leukemia Working Party of the ...the patients was ... Voir le document complet
8
Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients
... inherent in retrospective registry-based studies by studying a large patient cohort, by double-checking the RIC/ MAC information and by using early NRM as primary endpoint for estimating the impact of TCI, ... Voir le document complet
12
Physician Uncertainty Aversion Impacts Medical Decision Making For Older Patients With Acute Myeloid Leukemia: Results Of A National Survey
... Society of Hematology mailing list received a unique link to enter the survey or opt out. After duplicate names were removed, the panel of potentially eligible subjects contained 1337 physicians, including 220 residents ... Voir le document complet
10
Donor lymphocyte infusion to eradicate recurrent host hematopoiesis after allogeneic BMT for sickle cell disease.
... BMT for sickle cell disease Frederic Baron, Marie-Francoise Dresse, and Yves Beguin BACKGROUND: Donor lymphocyte infusion (DLI) is cur- rently standard therapy for relapse of ... Voir le document complet
3
Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia.
... importance for their response to therapeutic drugs and/or relapse of the ...reported in some cases of leukemic blasts from patients ...from patients further reinforce these data and suggest ... Voir le document complet
9
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
... washed with the same volume of NaCl ...completed in <20 ...cells in a centrifugation tube filled with 3 ml of a cold (−80°C) mixture of 80% methanol and 20% water and 200 µl ... Voir le document complet
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Transplant Outcomes for Secondary Acute Myeloid Leukemia: Acute Leukemia Working Party of the European Society for Blood and Bone Marrow Transplantation Study.
... occurs with an antecedent myeloid disease such as MDS or a myeloproliferative neoplasm (MPN) re- gardless of prior ...therapy for either a solid tumor or hematologic malignancy [4] . Studies ... Voir le document complet
9
Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia
... treatment in AML and the intensification of daunorubicin doses has been pivotal in establishing the standard induction treatment [ 16 ...used in AML ...complexes with topoisomerase II, thereby ... Voir le document complet
15
Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells
... cancer patients. In this study, we unveil different mechanisms that eliminate p53-R248Q, one of the most frequent mutants found in human ...which in addition further inhibits ...levels. ... Voir le document complet
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