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[PDF] Top 20 Preventing cell death with a ‘check valve’ in mitochondrial complex I?

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Preventing cell death with a ‘check valve’ in mitochondrial complex I?

Preventing cell death with a ‘check valve’ in mitochondrial complex I?

... work in Cell Death Discovery, 10 we have reported a hitherto unrecognized situation in which superoxide production driven by the reverse electron transfer is dramatically reduced, ... Voir le document complet

3

Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion

Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion

... β/CypD complex plays a pivotal role in the regula- tion of the mPTP 26 , 28 , 35 , 43 , and although it has been reported that the consensus sequence S/T-X-X-X-S/T is neither essential nor sufficient ... Voir le document complet

13

E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells.

E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells.

... as a novel essential regulator of this complex mitochondria-ROS-autophagy network that is implicated in cell survival of leukemic cells with deficiencies in the p53 and ... Voir le document complet

3

NMR metabolomics of fibroblasts with inherited mitochondrial Complex I mutation reveals treatment-reversible lipid and amino acid metabolism alterations

NMR metabolomics of fibroblasts with inherited mitochondrial Complex I mutation reveals treatment-reversible lipid and amino acid metabolism alterations

... to cell death in ...), in agreement with preservation of ATP levels in LHON in our ...impair mitochondrial trafficking to the sites of energetic needs, another ... Voir le document complet

10

A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death

A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death

... ΔΨm. In the heart, Epac1 was recently shown to be localized and functionally involved also in nuclear signaling, whereas Epac2 is located at the T tubules and regulates arrhythmogenic sarcoplasmic reticulum ... Voir le document complet

40

Cell Death Pathways in Photodynamic Therapy of Cancer

Cell Death Pathways in Photodynamic Therapy of Cancer

... ligands with their signaling ...most complex example is APO2/TRAIL, which binds five different receptors ...factor in immune response and such members like Fas and APO2/TRAIL induce apoptosis through ... Voir le document complet

25

Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

... the cell pellet (5x10 6 cells), mixed and placed into a 30 mL disposable ...into a 4 mm ZrO2 HRMAS rotor. All NMR experiments were carried out on a Bruker Advance III spectrom- eter operating ... Voir le document complet

20

Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.

Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.

... ineffective in preventing cell death in HL 60 cells ...stress in HL 60 cells. Some tissue-specificities in PTP regulation have been previously ...opening in ... Voir le document complet

9

Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan

Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan

... shown in Figure 1 in the light of the proposed ...can. In the structural model proposed here, the glycan parts form tight interactions in the groove formed by the LysM and catalytic domains of ... Voir le document complet

12

Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human.

Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human.

... constitutes a major issue for CPVT ...involved in this ...RyR2 in the dominant forms of CPVT and CSQ2 in the recessive ...defect. In the present work, we searched for mutations ... Voir le document complet

10

Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

... DCC-5Fbn, with or without addition of netrin-1 in excess to reverse the effect of ...DCC-5Fbn. Cell death was quantified by trypan blue exclusion assay (below panel) while apoptosis was ... Voir le document complet

37

Mitochondrial proteomics : analysis of a whole mitochondrial extract with two-dimensional electrophoresis.

Mitochondrial proteomics : analysis of a whole mitochondrial extract with two-dimensional electrophoresis.

... Progressive mitochondrial dysfunction has also been implicated in the aging ...interest in comparative mitochondrial proteomics. As many mitochondrial proteins are assembled into ... Voir le document complet

28

Giant-cell arteritis-related mortality in France: A multiple-cause-of-death analysis

Giant-cell arteritis-related mortality in France: A multiple-cause-of-death analysis

... died in France. Among them, the CépiDc recorded 4,628 death certificates reporting a diagnosis of GCA as UCD or ...deaths with GCA listed as UCD or NUCD, stratified by year during the study ... Voir le document complet

20

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL.

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL.

... depleted in p53 by RNA interference or not prior the assays, data not ...incubated with mitochondria isolated from BAX/BAK null mouse embryonic fibroblasts, this recombinant p53 did not trigger cytochrome c ... Voir le document complet

11

Role of RIP3 in PDT-induced glioblastoma Cell Death

Role of RIP3 in PDT-induced glioblastoma Cell Death

... RIP3 in PDT-induced glioblastoma Cell Death Glioblastoma are the deadliest type of brain ...associated with poor survival and a high degree of recurrence despite removal by surgical ... Voir le document complet

1

Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss

Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss

... using a 1 ml hand-driven glass– glass potter in 1 ml of ACBT buffer (aminocaproic acid ...measured with the BCA protein assay kit (Pierce ThermoScientific) and then kept at −20 °C until ...loaded ... Voir le document complet

16

Production of prodiginines is part of a programmed cell death process in Streptomyces coelicolor

Production of prodiginines is part of a programmed cell death process in Streptomyces coelicolor

... Cell Death Is the Trigger of PdG Biosynthesis Next to phenotypic characterization of mutants, a complementary means to uncover the role(s) played by a secondary metabolite in nature is ... Voir le document complet

12

Tissue-and Cell-Specific Mitochondrial Defect in Parkin- Deficient Mice

Tissue-and Cell-Specific Mitochondrial Defect in Parkin- Deficient Mice

... reduction in the enzymatic activity of complex I of the mitochondrial electron transport chain ...the in vivo relevance of the PINK1/Parkin-dependent mitochondrial quality ... Voir le document complet

13

Bacteriocyte cell death in the pea aphid/ Buchnera symbiotic system

Bacteriocyte cell death in the pea aphid/ Buchnera symbiotic system

... weevils, a coleopteran species symbiotically associated with the Sodalis pierantonius bacterium, have revealed a distinct mechanism of bacteriocyte degeneration ...(21). In this recently ... Voir le document complet

11

Dynamical Boolean Modeling of Immunogenic Cell Death

Dynamical Boolean Modeling of Immunogenic Cell Death

... immunogenic cell death (ICD) constitutes a type of cellular demise that elicits an adaptive immune ...characterized in malignant cells following cytotoxic interventions, such as chemotherapy ... Voir le document complet

13

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