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Prevalence of HIV-1 drug resistance in treated patients with viral load >50 copies/mL in 2009: a French nationwide study
... the prevalence of HIV-1 resistance to antiretro- viral drugs in treated patients with viral loads ....50 copies/mL ... Voir le document complet
6
Development of HIV with Drug Resistance after CD4 Cell Count—Guided Structured Treatment Interruptions in Patients Treated with Highly Active Antiretroviral Therapy after Dual—Nucleoside Analogue Treatment
... gene. In our study, positions 10, 20, 63, and 77 were ...significant drug resis- tance by themselves, some of them contribute to drug resistance when present together with ... Voir le document complet
7
HIV Viral Load Monitoring in Resource-Limited Regions: Optional or Necessary?
... can a viral load test be made af- fordable and practical for this use? The answer to the first question de- pends on the biology of virological fail- ure and the availability of ... Voir le document complet
7
INSTI-Based Triple Regimens in Treatment-Naïve HIV-Infected Patients Are Associated With HIV-RNA Viral Load Suppression at Ultralow Levels
... METHODS Study Design and Population Between 2009 and 2013, HIV-1-infected antiretroviral-naïve patients were selected from 2 French university hospitals (Pitié- Salpêtrière and ... Voir le document complet
10
Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients.
... analyses of transmitted drug resistance and HIV-1 subtype distribution in Europe ...[5,6]. A standard- ized sampling strategy was designed by the epidemiology expert group ... Voir le document complet
13
Assessments of HIV Drug Resistance Mutations in Resource-Limited Settings
... HIVDR in 682 patients with chronic HIV in- fection (median CD4 cell count, 100 cells/mm 3 ) who started ART at 8 sites in Hong Kong, Malaysia, and Thailand and reported a ... Voir le document complet
3
Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: Findings from a cross-sectional study
... free-of-charge in the national AIDS program in Chad since 2007, with first-line regimens consisting of two nucleoside reverse transcriptase inhibitor (NRTI) and one non-NRTI ...consist ... Voir le document complet
10
Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal.
... number of Pfmdr1 The Pfmdr1 copy number was estimated by TaqMan real-time PCR (7900HT Fast Real-Time PCR system, Applied Biosystems, Courtaboeuf, France) using the single-copy gene β-tubulin (PF10_0084) as ... Voir le document complet
11
Synthetic lethals in HIV: ways to avoid drug resistance
... nature of the target with in-silico docking using large ...orientation of each chemical in the cartesian coordinates system of the ...selection of these parameters de- ... Voir le document complet
14
Point-of-Care Cepheid Xpert HIV-1 Viral Load Test in Rural African Communities Is Feasible and Reliable
... two viral load assays, we used the Bland-Altman plot ...limits of two standard deviations of the ...packages in R ...errors in both variables have the same ...sampled with ... Voir le document complet
7
Syphilis infection is associated with an increase in plasma viral load in HIV infected patients: results from the FHDH cohort -- ANRS CO4
... associated with an increase in plasma viral load in HIV infected patients: results from the FHDH cohort – ANRS CO4 W Jarzebowski, Christophe Piketty, Pierre de Truchis, ... Voir le document complet
3
Adjustment disorders: prevalence in a representative nationwide survey in Germany
... impact of each event. The CP for each type of acute and chronic stressor was calculated (Table 4 ...AjD with any of the listed events was 4.02%. With respect to CPs for each particular ... Voir le document complet
8
Synthetic lethals in HIV: ways to avoid drug resistance
... In a preliminary work taking the HIV protease as a model, [7,21,22], we described positions involved in SDL ...knowledge of the amino acid (AA) positions is just part of ... Voir le document complet
14
HIV Drug Resistance Early Warning Indicators in Cohorts of Individuals Starting Antiretroviral Therapy Between 2004 and 2009: World Health Organization Global Report From 50 Countries
... clinics in our sample were able to monitor this EWI in- dicating that capacity to perform VL testing remains limited in the majority of settings ...nerstone of EWI monitoring. ... Voir le document complet
10
Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV
... assessments of the full systemic impact of ...differences in treatment regimens with varying CNS penetration effectiveness scores, duration of treatment, and standards of ... Voir le document complet
16
Assessing the Paradox Between Transmitted and Acquired HIV Type 1 Drug Resistance Mutations in the Swiss HIV Cohort Study From 1998 to 2012
... currence of L90M among recently infected, treatment-naive pa- tients has increased years after the PVL from nonresponding patients carrying L90M started to decrease (Figure 4 ), resulting in the ... Voir le document complet
11
Structural Impacts of Drug-Resistance Mutations Appearing in HIV-2 Protease
... atoms of residue 25 in the L90M mutant of PR2; atoms of residue 25A/B exhibit an average dist WT−mutant of ...Å. In addition, we noted that the I84V and L90M mutations have not ... Voir le document complet
27
Association of UV radiation with Parkinson's disease incidence: A nationwide French ecologic study
... located in Hall B, Level 2 Association of UV radiation with Parkinson’s disease incidence: A nationwide French ecologic study ... Voir le document complet
3
Coevolution analysis of amino-acids reveals diversified drug-resistance solutions in viral sequences: a case study of hepatitis B virus
... The study of mutational landscapes of viral proteins is fundamental for the understanding of the mechanisms of cross-resistance to drugs and the design of effective ... Voir le document complet
17
Prevalence and prediction of gastric mucosal abnormalities in a prospective series of 50 patients with graves-Basedow disease
... PREVALENCE AND PREDICTION OF GASTRIC MUCOSAL ABNORMALITIES IN A PROSPECTIVE SERIES OF 50 PATIENTS WITH GRAVES-BASEDOW DISEASE Dr H Valdes-Socin, M Tome-Garcia, L ... Voir le document complet
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