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[PDF] Top 20 Pharmacological Targeting of IRE1 in Cancer

Has 10000 "Pharmacological Targeting of IRE1 in Cancer" found on our website. Below are the top 20 most common "Pharmacological Targeting of IRE1 in Cancer".

Pharmacological Targeting of IRE1 in Cancer

Pharmacological Targeting of IRE1 in Cancer

... which in turn induces glycolysis and response to hypoxia [61,62]; iii) controls the transcription of genes coding for vascular endothelial growth factor a (VEGF-A), IL-6 and other proangiogenic signals ... Voir le document complet

34

Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

... level of one protein of each of the five mitochondrial respiratory complexes by western blotting (WB) using an OXPHOS antibodies cocktail ( Figures 2 F and S3 ...abundant in Panc-1 and SOJ-6 ... Voir le document complet

20

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

... OXPHOS in cancer ...effects of different doses of resveratrol (1 to 50 µM, 48 hr) on glucose utilization in colon cancer ...(65%) of the ability of Caco2 ... Voir le document complet

17

An auristatin‐based antibody‐drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer

An auristatin‐based antibody‐drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer

... death of pancreatic tumor cells. In vivo, the MMAE-based HER3-ADC induces a more robust and prolonged radiation response, thus improving tumor control in ...dose of 2.5 to 5 mg/kg HER3-ADC ... Voir le document complet

46

Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

... level of 43.5pmol/mg protein in the TNBC (HR - /HER - ) subtype that was not significantly different from that of the other BC subtypes (Additional file 1: Figure S1), and was in the range ... Voir le document complet

57

Targeting Cancer Stem Cells to Overcome Chemoresistance

Targeting Cancer Stem Cells to Overcome Chemoresistance

... 220. Classe, J.M.; Glehen, O.; Decullier, E.; Bereder, J.M.; Msika, S.; Lorimier, G.; Abboud, K.; Meeus, P.; Ferron, G.; Quenet, F.; et al. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for First ... Voir le document complet

25

Co-targeting EGFR and mTOR with gefitinib and everolimus in triple-negative breast cancer cells

Co-targeting EGFR and mTOR with gefitinib and everolimus in triple-negative breast cancer cells

... °C in a humidified atmosphere of 95% air and 5% CO2 26 , 27 ...cultured in RPMI 1640 and CAL-51 in DMEM medium (Invitrogen Life Technologies, Carlsbad, CA, ...cultured in Ham’s F-12 ... Voir le document complet

13

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

... for in vivo siRNA delivery in mice ...fficiently in tumor tissues and (C, D) is much more potent than the nontargeted siRNA/AD system for gene silencing and anticancer activity in tumor ... Voir le document complet

12

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

... role of CD39 in the MCA205 fibro- sarcoma model to challenge our findings obtained with B16F10 melanoma ...control of MCA205 tumor growth ( Figure S2 ...treatment in WT mice had weak effect on ... Voir le document complet

26

Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy

Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy

... TGI of 46% after 11 days of treatment compared to control mice treated with the formulating ...weeks in mice bearing HBCx-12A tumours (triple negative ...weeks in mice bearing HBCx-12A tumours ... Voir le document complet

13

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en fr Progesterone Receptor Isoforms : functional Selectivity and Pharmacological Targeting Isoformes du récepteur de la progestérone : sélectivité fonctionnelle et ciblage pharmacologique

... implicated in the progression of breast cancers frequently associated with imbalanced PRA/PRB expression ...degradation/stability in the context of agonist and antag- onist ligands, we used ... Voir le document complet

278

A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

... performed in agreement with the French Guidelines for animal handling and approved by the local ethic committee (C2EA14) for Animal Experimentation (Agreement ...cells/mice) in a 1/2 (v/v) Matrigel (Corning ... Voir le document complet

14

Stellate cells and the development of liver cancer: Therapeutic potential of targeting the stroma

Stellate cells and the development of liver cancer: Therapeutic potential of targeting the stroma

... induction of HSC apoptosis may be achieved by nanoparticules or gene transfer systems designed to inhibit NF- B transcription factor which controls HSC activation and proliferation ...apoptosis of HSC ... Voir le document complet

18

Development of a pharmacological protocol of stress echocardiography in horses

Development of a pharmacological protocol of stress echocardiography in horses

... en conclusion, cette quatrième étude de notre travail a démontré que les intervalles de temps systoliques et la vitesse de raccourcissement des fibres circonférent[r] ... Voir le document complet

7

Drug-Initiated Synthesis of Heterotelechelic Polymer Prodrug Nanoparticles for In Vivo Imaging and Cancer Cell Targeting

Drug-Initiated Synthesis of Heterotelechelic Polymer Prodrug Nanoparticles for In Vivo Imaging and Cancer Cell Targeting

... dose of Gem, led to a significant reduction of the tumor growth compared to control experiments, with tumor volume ratios reaching a value of ...effect of Gem- PI prodrug nanoparticles over ... Voir le document complet

38

Pharmacological prevention of type 2 diabetes.

Pharmacological prevention of type 2 diabetes.

... prevention of type 2 diabetes in high-risk individuals, especially those with IGT ...event in the natural history of T2DM, recent studies have clearly demonstrated that there is an early ... Voir le document complet

46

A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

... density of target cells in 3D format enhances NK cell activation by promoting MesobsFab mediated serial contacts between NK and tumor cells ( 37 , 38 ) and/or the engagement of other activating ... Voir le document complet

14

Pharmacological treatments

Pharmacological treatments

... [76]. In uncontrolled case studies, some impressive cases of recovery were reported in UWS patients who were treated with baclofen in the subacute setting ...effect of baclofen was also ... Voir le document complet

26

Cellular heterogeneity mediates inherent sensitivity–specificity tradeoff in cancer targeting by synthetic circuits

Cellular heterogeneity mediates inherent sensitivity–specificity tradeoff in cancer targeting by synthetic circuits

... | cancer gene therapy | cell-state targeting | mammalian synthetic biology T he design of gene circuits capable of precisely targeting cancer cells is a major challenge in ... Voir le document complet

7

Brain connectivity in pathological and pharmacological coma

Brain connectivity in pathological and pharmacological coma

... point of view, most presented studies rely on functional connectivity which measures temporal correlation between cerebral activities in distinct brain areas but cannot infer ...used in studies on ... Voir le document complet

6

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