[PDF] Top 20 The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.
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The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.
... but is involved in tumorigenesis. One interesting possibility is that upregulation of LRH1 expression could account for the differential effects of E2 in normal epithelial cells compared to breast ... Voir le document complet
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The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.: PPARalpha controls the expression of the sIL-1ra in liver
... Interleukin 1 Receptor antagonist is a direct target gene of PPAR with a functional PPRE in its promoter, suggesting that PPAR may also govern inflammation by direct up-regulation ... Voir le document complet
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RhoB modifies estrogen responses in breast cancer cells by influencing expression of the estrogen receptor.
... induces an increase of active GTP-RhoB within 30 min- utes, without changing RhoB expression at that ...downregulates the transcription of hundreds of genes [41] and PR is a well-known ERa ... Voir le document complet
14
The purinergic p2x7 receptor-nlrp3 inflammasome pathway: A new target in alcoholic liver disease?
... in the pathophysiol- ogy of alcoholic ...causes the passage of various PAMPS from the intestinal tract to the bloodstream, including bacterial and fungal prod- ...its receptor, TLR4, to ... Voir le document complet
14
Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer
... (BC) is a heterogeneous disease that differs at the genetic, histopathological and clinical levels [ 12 ...defined: Estrogen/Progesterone Receptor positive (ER + /PR + ), Human Epidermal ... Voir le document complet
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Study of nuclear receptor dynamics by BRET
... between nuclear receptor corepressors and coactivators is that corepressors do not possess intrinsic enzymatic activity and rely on the recruitment of HDACs, whereas coactivators interacting ... Voir le document complet
266
The orphan nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2) regulates decidualization
... an agonist and an inverse agonist for the nuclear ...that the modulation of LRH-1 activity by its ligands also affects the decidual ...have the capacity to migrate ... Voir le document complet
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Modulation of estrogen related receptor alpha activity by the kinesin KIF17
... and estrogen production, and this resistance is partially attributable to ligand- independent activities of ERR1, loss of ER-mediated competition for regulatory cofactors, and the ability of ERR1 to ... Voir le document complet
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Estrogen-mediated neuroprotection in the cortex may require NMDA receptor activation
... for estrogen-mediated neuroprotection following experimental stroke is a result of modulating glutamate-me- diated ...rats, estrogen injection (systemic or direct intracortical injec- tion) resulted ... Voir le document complet
11
The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.
... investigate the respective roles of these transcriptional regulators in mediating the effect of fipronil on hepatic gene expression, we used CAR- and PXR-deficient ...that the panel of genes ... Voir le document complet
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Plasma estrogen levels, estrogen receptor gene variation, and ischemic arterial disease in postmenopausal women: the three-city prospective cohort study.
... estradiol, estrogen receptor gene variation and ischemic arterial disease in postmenopausal women: the Three-City prospective Cohort Study " submitted for publication as an original ... Voir le document complet
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Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis.
... through an important modification of tumor vasculature that appears normalized as described by Carmeliet and Jain (26, ...hypoxia is a negative prognostic factor associated to chemo- and radio-resistance ... Voir le document complet
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Rôle du Liver X Receptor dans la régulation transcriptionnelle de la lipogenèse
... measuring the expression of 142 genes involved either in lipid metabolism or in nuclear receptor signalling, we were able to further evaluate the role of ...of gene expression as their ... Voir le document complet
282
Regulation of the Aldo-Keto Reductase Gene akr1b7 by the Nuclear Oxysterol Receptor LXRα (Liver X Receptor-α) in the Mouse Intestine: Putative Role of LXRs in Lipid Detoxification Processes
... Although the diet is an indispensable source of nu- trient lipids, at high concentrations these lipids (espe- cially cholesterol) become toxic to cells ...at the top of this protective pathway ... Voir le document complet
11
Involvement of cyclic AMP response element binding protein (CREB) and estrogen receptor phosphorylation in the synergistic activation of the estrogen receptor by estradiol and protein kinase activators.
... using the reporter gene constructs and the two cell lines gave results which indicated that CREB was involved in mediating the PKA-ER ...enhanced the transcriptional activity of ER on ... Voir le document complet
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Receptor-interacting protein 140 is a repressor of the androgen receptor activity.: AR repression by RIP140
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ... Voir le document complet
10
The hedgehog receptor patched is involved in cholesterol transport.
... diluted 1:50 in sodium borate buffer, pH 8.5, for covalent thiol- coupling to the flow cell 2 (fc2) of a CM5 sensor ...chip. The flow cell 1 (fc1) was activated without thiocholesterol and ... Voir le document complet
12
Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism
... the most abundant ions ...modifications: the recurrent loop of the 10 most intense nLC-eluting peptides were HCD-fragmented between each full scan (data dependent ...AGC target 1,10e6 within ... Voir le document complet
19
Liver X Receptor: an oxysterol sensor and a major playerin the control of lipogenesis
... as an increase of 24(S),25- epoxycholesterol synthesis and up-regulation of LXR activity in THP-1 human macrophages ( Beyea et ...evidenced the role of endoge- nous ...expressed the ... Voir le document complet
16
Gene Structure, Expression, and 5-HT2B Receptor Signaling
... coupled receptor (GPCR); G- protein coupled receptor kinase (GRK); Heparin-binding epidermal growth factor (HB-EGF); Hepatic stellate cell (HSC); Hepatocellular carcinoma (HCC); Histone deacetylase (HDAC); ... Voir le document complet
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