[PDF] Top 20 Novel insights into the development and maintenance of the blood-brain barrier
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Novel insights into the development and maintenance of the blood-brain barrier
... Outlook The last few years have provided a substantial body of novel mechanistic insights into the development and differentiation of the ...BBB. ... Voir le document complet
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The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction
... Although the BBB and the BCSFB can be localized to highly specialized brain microvascular endothelial cells and choroid plexus epithelial cells, respectively; it has become evident that ... Voir le document complet
15
Development of a physiologically accurate 3D blood-brain barrier hydrogel model
... Since the ratio of 4 uL ...ratio, and the extra cell media added to the hydrogel also contributes to neutralize the sample, it was decided that this ratio would be used in order ... Voir le document complet
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Blood-Brain Barrier Penetration of Zolmitriptan—Modelling of Positron Emission Tomography Data
... to the inclusion of radiolabelled metabolites, does enter brain tis- sue and that at a level which approaches 25% of the plasma concentra- ...tion. The rate of ... Voir le document complet
17
Molecular mechanism of ultrasound interaction with a blood brain barrier model
... DISCUSSION AND CONCLUDING REMARK In the HIFU experiments the direct interaction of ul- trasound with the BBB is the cause of the BBB disrup- ...For the LIFU ... Voir le document complet
22
Methodologies to Assess Drug Permeation Through the Blood-Brain Barrier for Pharmaceutical Research
... in the early drug discovery and development processes are as follows: is the chemical CNS active? Is the drug a substrate of influx or efflux transporters? Is the drug ... Voir le document complet
28
Emerging technologies for delivery of biotherapeutics and gene therapy across the blood–brain barrier
... Promise of Extracellular Vesicles Exosomes have recently emerged as novel lipid nanocarriers for the delivery of small molecule drugs, protein- [ 81 , 82 ], and gene-based ... Voir le document complet
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The importance of the Hedgehog signaling pathway at the level of the blood-brain barrier
... vascular development is characterized by sequential steps of vasculogenesis, angiogenesis, and in some organs, ...In the CNS, the blood- brain barrier (BBB) is ... Voir le document complet
146
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation.
... part of the interpretation of these apparently conflicting data may be found in the heterogeneity of the PKC ...family. The Ser/Thr-kinases PKCs are indeed classified ... Voir le document complet
13
New insights on ammonia metabolism in endothelial cells of the blood brain barrier
... complication of liver disease. Cytotoxic edema is a serious complication of HE, known to be the result of astrocyte ...swelling. Blood derived pathogenic factors such as ammonia (NH 4 + ... Voir le document complet
111
The pericyte–glia interface at the blood–brain barrier
... for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...not. The documents may come from teaching and research institutions in France or ... Voir le document complet
15
Novel insights into the morphology of Plesiochelys bigleri from the early Kimmeridgian of Northwestern Switzerland
... Fig 3. Basicranium MJSN CBE-0002. Photographs and interpretative drawings in dorsal view (A-B), in ventral view (C-D) and in anterior view (E-F). Abbreviations: bo, basioccipital; bs, basisphenoid; caj, ... Voir le document complet
17
Disruption of the blood-brain barrier by intra-arterial administration of papaverine: a technical note
... was the result of a combination of factors in which pathological hemodynamics due to vasospasm caused an unexpected high concentration of papaverine in perforator vessels, leading to BBB ... Voir le document complet
5
Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier
... under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...locally, and ... Voir le document complet
15
Spatially broad opening of the blood-brain barrier with an unfocused ultrasound transducer in rabbits
... Spatially broad opening of the blood-brain barrier with an unfocused ultrasound transducer in rabbits K. Beccaria a , M. S. Canney b , L. Goldwirt c , C. Fernandez c , C. Adam d , G. ... Voir le document complet
2
New insights into the tetraspanin Tspan5 using novel monoclonal antibodies
... Generation of antibodies recognizing Tspan5 To generate anti-Tspan5 mAbs, we immunized mice twice with U2OS cells stably expressing Tspan5-GFP and twice with a Tspan5-GFP ...Because the human, mouse, ... Voir le document complet
18
Endosomal trafficking regulates receptor-mediated transcytosis of antibodies across the blood brain barrier
... to the monomeric BBB-crossing anti- body FC5, both Mono-FC5Fc and Bi-FC5Fc demon- strated a significantly improved BBB transcytosis in vitro and in ...11 The examination of intracellu- ... Voir le document complet
15
Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
... To integrate these features into a physiologically relevant blood-brain barrier model, we designed an in vitro microvascular network platform formed via vasculogenesis[r] ... Voir le document complet
58
Novel insights into the molecular pathogenesis of CYP4V2 -associated Bietti's retinal dystrophy
... reveal the fine inner retinal crystals as well as the larger sometimes encapsulated subretinal ...cohort of crystalline retinal dystrophies, clinically diagnosed as Bietti crystalline ...four ... Voir le document complet
17
The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action
... oxygen and nitrogen species-triggered DNA damage. Moreover, we show that the DNA binding activity of ...intermediates of DNA repair, is correlated to the amount of ... Voir le document complet
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