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NOTCH, a new signaling pathway implicated in holoprosencephaly.

NOTCH, a new signaling pathway implicated in holoprosencephaly.

... haploinsufficiency in adult mice leads to a reduce body weight (53) Nevertheless no investigations of possible fine structural abnormalities of the forebrain have been ...result in embryonic death ... Voir le document complet

32

New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?

New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?

... on a transformation from an epithelial to a mesenchymal phenotype, promoting the invasive capacities of cancer ...increase in mesenchymal markers including N-cadherin, vimentin and ...EMT in ... Voir le document complet

23

Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders

Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders

... and Notch signaling pathways appear to be functionally ...providing a new mechanism by which hypoxia can regulate the responses of vascular cells ...Dll4 in endothelial cells, leading ... Voir le document complet

27

C. elegans Notch Signaling Regulates Adult Chemosensory Response and Larval Molting Quiescence

C. elegans Notch Signaling Regulates Adult Chemosensory Response and Larval Molting Quiescence

... model in which OSM-11 and Notch signaling modulate neuronal function, behavior, and adaptation to environmental ...changes in C. elegans. Increased external osmolarity decreases OSM-11 levels ... Voir le document complet

11

The Notch signaling pathway involvement in innate lymphoid cell biology

The Notch signaling pathway involvement in innate lymphoid cell biology

... The Notch signaling pathway Notch signaling was first defined in the context of cell fate decisions during Drosophila melanogaster development [ 13 ...the Notch ... Voir le document complet

12

Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway

Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway

... occur in CLL. The triggering of IFN receptors is believed to be involved in the survival of CLL cells, but the underlying molecular mechanisms are not yet ...STAT3/Mcl-1 pathway by pharmacological ... Voir le document complet

16

Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species

Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species

... is a more efficient elicitor of Ca 2+ spiking in root atrichoblasts of both ...presented in this figure for all the CO4 and Myc-LCO treatments were obtained in the presence of acetonitrile ... Voir le document complet

14

Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner.

Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner.

... used a mammalian two-hybrid transactivation assay aimed at measuring Smad3/RAR  ...interactions. In such system, the Gal4-lux reporter construct is co-transfected with an expression vector for the ... Voir le document complet

27

Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes

Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes

... provided a new avenue and been considered having great ...is a natural pentacyclic triterpenoid and present in many different plants, fruits and ...mass in mice fed a high-fat ... Voir le document complet

9

Cross talk between fanconi anemia and unc5a signaling pathway

Cross talk between fanconi anemia and unc5a signaling pathway

... is a developmental deficiency disease, suggesting that FA proteins have functions other than those associated with DNA damage repair, for instance, in tissue ...FANCC, a predominantly cytoplasmic ... Voir le document complet

141

Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old wistar rats

Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old wistar rats

... analysis A 50-mg sample of TA muscle was lysed in an ice-cold lysis buffer (50 mM HEPES pH ...using a Micro BCA TM Protein assay kit (Thermo Scientific, MA, United ...dissolved in a ... Voir le document complet

14

Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway

Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway

... ephrin-A:EphA signaling is implicated in a diversity of pathological ...conditions. In the heart, ephrin-A forward signaling promotes the regenerative ability of cardiac ... Voir le document complet

24

Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old Wistar rats

Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old Wistar rats

... * Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old Wistar rats Domingues-Faria C. 1,2,4 , Chanet A. 2,4 , Salles J. 2,4 , Berry A. 2,4 , ... Voir le document complet

2

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

... paired in their ability to migrate toward ear lymphatic vessels (Figs. 3 a and S3 ...role in guiding DCs to lymphatic vessels (Heuzé et ...be a likely source of Plexin-B1 to attract DCs via ... Voir le document complet

18

A lymphotoxin-driven pathway to hepatocellular carcinoma.: Sustained hepatic LT signaling causes HCC

A lymphotoxin-driven pathway to hepatocellular carcinoma.: Sustained hepatic LT signaling causes HCC

... aberration in HCC samples of tg1223 livers in relation to C57BL/6 samples were investigated using aCGH (Agilent DNA Analytics ...normalized in a linear way using DNA Analytics centralization ... Voir le document complet

144

Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression

Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression

... JAK/STAT signaling inhibition in Treg at the molecular level In order to determine whether inhibiting JAK/STAT signaling pathway in Treg might impact other genes than Foxp3 ... Voir le document complet

17

A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death

A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death

... as a key effector in mitochondrial cAMP ...2+ in isolated mitochondria using the Rhod-2 fluorescent ...(MCU) in the IM. As anticipated, 10 µM CGP37157, a mNCX inhibitor, accelerated Ca ... Voir le document complet

40

CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

... INVOLVED IN VARIOUS DISEASES CD9 Drives Different Processes Important for Viral and Bacterial Infections Within TEMs, CD9 modulates various virus-induced processes at the membrane, including membrane fusion, viral ... Voir le document complet

13

Clinical utility gene card for: Holoprosencephaly.

Clinical utility gene card for: Holoprosencephaly.

... In prenatal, ultrasound can detect central nervous system and facail abnormalities of severe HPE as early as the first trimester, but is less sensitive for detection of milder forms of HPE, such as lobar HPE. ... Voir le document complet

7

The purinergic p2x7 receptor-nlrp3 inflammasome pathway: A new target in alcoholic liver disease?

The purinergic p2x7 receptor-nlrp3 inflammasome pathway: A new target in alcoholic liver disease?

... stages in ALD: hepatic steatosis, steatohepatitis, and ...lipids in and around the ...alcohol in less than 2 h). Liver steatosis is reversible and therefore has a good prognosis, although ... Voir le document complet

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