Haut PDF NLRP3 controls ATM activation in response to DNA damage
NLRP3 controls ATM activation in response to DNA damage
... HAL Id: hal-03093041 https://hal.archives-ouvertes.fr/hal-03093041 Preprint submitted on 5 Jan 2021 HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci- entific research documents, ...
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Role of ATM in the telomere response to the G-quadruplex ligand 360A.
... triggered DNA damage signaling outside telomeres that could be indicative of the formation of G-quadruplex structures at interstitial sites, as pro- posed previously ...functional ATM for this ...
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Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response
... branched DNA intermediates resulting from HR and/or arrested replication fork ...role in resolving HR intermediates, suppressing chromosomal instability ...(including DNA lesions, R-loops, repetitive ...
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DNA damage response upon environmental contaminants: an exhausting work for genomic integrity
... reduction in glucose ...and DNA damage ...of DNA topoisomerase II binding protein 1 (TopBP1) ...SIRT1 activation, transducing ToBP1 deacetylation and thereby inhibiting DNA ...
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Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation
... Innate response during inflammation is assured by the family of the evolutionarily con- served NLR receptors (Nucleotide-binding domain and Leucine-rich Repeat containing pro- teins) expressed mainly in ...
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Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability
... arrests in the adaptation ...checkpoint activation in response to telomeric ...involved in adaptation also play roles in DNA damage repair and checkpoint ...
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DNA damage and the activation of the p53 pathway mediate alterations in metabolic and secretory functions of adipocytes Running title: DNA damage and p53 in obese adipocytes
... deregulated in one or both experimental conditions ...regulation in response to doxorubicin, except for CXCL1 ...and activation by doxorubicin (Supplementary ...activity. In this ...
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14-3-3 Proteins, FHA Domains and BRCT Domains in the DNA Damage Response
... does to control the DNA damage response and coordinate DNA repair remains ...PTIP in transcription ...recruited to IRIF by PTIP [83]. In addition, Gong and ...
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Role of the Polymerase ϵ sub-unit DPB2 in DNA replication, cell cycle regulation and DNA damage response in Arabidopsis
... tolerance to different types of DNA damage that trig- ger replicative stress or DNA breaks, may be due to consti- tutive activation of ATR, and /or ...ATM. To ...
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Cell-Based Biosensor to Report DNA Damage in Micro- and Nanosystems
... engineered to report on DNA damage induced by micro- and ...on activation of p21, a crucial and well-characterized node in the DNA damage and cell cycle arrest pathway, ...
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Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs
... shown to be required for the integrity of the BRCA1A complex containing RAP80, BRCA1, BRCC36 and CCDC98 [ 24 ] [ 25 ...loaded to chromatin bound by TNKS1. We indeed found that RAP80 was recruited to ...
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Evaluating DNA damage response (DDR) activation in human prostate cancer
... biology in individual prostate cancer patient is still not taken into consideration for clinical management of the ...disease. In an era of evolving personalized medicine, we confirmed that RELA (p65) and ...
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Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation
... instrumental in many bacterial species to face the threat of antibiotics, by allowing them to evolve and adapt to these hostile ...transferred to plasmidless recipient cells as ...
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Uropathogenic E. coli induces DNA damage in the bladder
... island in UPEC cannot merely be reduced to a determinant of intestinal col- ...active in the urinary tract and even within IBCs. Bacterial multiplication in these structures is intense, with a ...
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Comet assay on thawed embryos: An optimized technique to evaluate DNA damage in mouse embryos
... presented in Table 2 ...retrieved. In these studies, fresh embryos were all obtained by natural mating ( Fabian et ...removed in 4 studies; The protocols for the transfer of the embryos in the ...
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Damage response of sandwich plates subject to dynamic loads
... The analytical predictions for the central deflection of the plate when subjected to low velocity impact loads are within 5% error for the fully-plastic, isotropic facesheet and 1[r] ...
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Electrical discharges in water induce spores' DNA damage
... AFM in liquid validated these observations at the nanoscale and no variation of roughness was ...arcs. In the literature, the shock waves are currently described as an efficient method to inactivate ...
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Uropathogenic E. coli induces DNA damage in the bladder
... cells, including in urothelial regenerative cells and that colibactin is produced by pks+ UPEC.. 618[r] ...
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A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response
... defective in their response to replication stress, we subjected FMRP KO MEFs to additional sources of replication stress agents including hydroxyurea (HU) and UV ...irradiation. In both ...
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The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage
... gested to function in the repair of oxidative DNA ...CSB in base excision repair (BER), the dedicated path- way to remove abundant oxidative DNA damage, could be ...
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