[PDF] Top 20 Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals

... Conclusions Dendritic cells have now been recognized as the most efficient antigen-presenting cells for the initiation of innate and adaptive immune ...responses. By delicately ... Voir le document complet

... an activation marker on mNK cells in vivo We argued that, if B220 + NK cells (formerly known as IKDC) occur in vivo as a result of NK cell activation, the spontaneous occurrence of B220 ... Voir le document complet

... infection and chronic liver disease (1). Acute HCV is characterized by a significant delay in the onset of adaptive T cell responses despite active viral ...replication and provide the ... Voir le document complet

... their inhibitory MHC class I ligands in the recipient, leaving a subpopulation of donor NK cells free from inhibition, referred to as “alloreactive” NK ...NK cells transplanted in C2/C2 individuals ... Voir le document complet

... Natural Killer (NK) cells are innate lymphoid cells (ILC) with cytotoxic and regulatory ...regulated by an array of inhibitory and activating receptors, ... Voir le document complet

... NK cells also present several cell-surface activating receptors such as: NKG2D, DNAX accessory molecule- 1 (DNAM-1), an adhesion molecule physically and functionally associated to Lymphocyte ... Voir le document complet

... reactive and hyporesponsive NK cells (data not ...NK cell education (data not ...reactive cells would get preferential access to ...education signals. This initial activity would then ... Voir le document complet

... malignancies, natural killer cells, natural cytotoxicity receptors, immune escape, immunotherapy INTRODUCTION The natural killer (NK) cells are central players in innate ... Voir le document complet

... 1 and type 2 diabetes are growing public health ...Invariant natural killer T (iNKT) cells are innate-like T cells that recognize glycolipids presented by ...These cells ... Voir le document complet

... ABSTRACT Natural killer (NK) cells play a protective role against dengue virus (DENV) infection, but the cellular and molecular mechanisms are not fully ...NK cells, through the ... Voir le document complet

... NK cells can dramatically decrease the intensity and duration of pDC activation by controlling viral burden, which prevents the production of very high systemic levels of IFN-a/b, and ... Voir le document complet

... HLA-E cell surface molecules. As shown in figure 4A (and S5A), decidual fibroblasts expressed both the nonclassical HLA-E and the classical HLA-A,-B,-C molecules at their ...downregulation by ... Voir le document complet

... production and through killing of infected cells (Loh et al, 2005), provided that the combination of the mouse and virus strains used allows NK-cell recognition of, activation ... Voir le document complet

... caused by an uncontrolled Kit activation, clinical trials based on the use of tyrosine kinase inhibitors have been conducted in mastocytosis ...mast cell activation in vitro and, when ... Voir le document complet

... composed by a family of five members that can form homo or heterodimers, depending on the cell type and stimulus [12–14] ...cytoplasm by their binding to the inhibitory j B (I j B) ... Voir le document complet

... shown by the small number of CD39-expressing NK cells from HC ...NK cells and might participate to their impaired functions in the context of ...NK cells from COVID- 19 patients may ... Voir le document complet

... T cell receptor (TCR) ? T cells, this process starts at their pre- cursor stage during thymic selection and continues in the periphery in antigen-naı¨ve and antigen-experienced (memory) T ... Voir le document complet

... fingers and subsequent fast, progressive centripetal skin ...tation and the presence of anti-topoisomerase-1 antibo- dies, she was diagnosed with SSc with diffuse cutaneous involvement reaching a modified ... Voir le document complet

... characterized by endothelial cell activation leading to increased expression of adhesion molecules such as inter-cellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, ... Voir le document complet

... Ito Cells Express CD1 Molecules and APC Surface Markers In order to investigate the impact of Ito cells on NKT cells, we isolated Ito cells from liver of C57BL/6 mice via the pro- nase ... Voir le document complet