[PDF] Top 20 Myeloid malignancies: mutations, models and management.
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Myeloid malignancies: mutations, models and management.
... IDH1/2 mutations are more frequent in acute than in chronic myeloid diseases, whereas it is not the case for TET2 alterations, which are more evenly dis- tributed between chronic and acute ...cells ... Voir le document complet
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Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
... AML and myeloid malignancies, including TET2, CEB PA, DNMT3A, IDH1, and IDH2, was ...alignment and SNP PET SNP Caller (Illumina) algorithm was used to identify SNP and IND ELs ... Voir le document complet
16
Targeted Therapies in Adult B-Cell Malignancies
... lenalidomide and dexamethasone in patients having relapsed MM with promising results, 90% of the patients achieving a partial response (PR) with PFS exceeding 2 years [ 30 ...ongoing and is due to be ... Voir le document complet
18
Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.
... ASXL1 mutations found in myeloid malignancies affect the twelfth exon of the gene although rare mutations in other exons have been detected ...ASXL1 mutations are frameshift and ... Voir le document complet
7
Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
... enzymes and the possible lines of communication between Tet1 and Tet2 in ho- meostasis of hematopoiesis and pathogenesis of hematological malignancies; (2) despite their similar catalytic ... Voir le document complet
15
Natural killer cells modulation in hematological malignancies
... tors and/or ligand corresponds to an immune escape mechanism for ...relapse and acute graft-versus-host disease (GvHD) ( 63 ...morbidity and mortality that limit its use ( 64 ... Voir le document complet
9
Going forward with the history of French management models and practices
... sociology, and political sciences. New teaching and learning institutions appeared, lessons were organised, and demand increased for teaching positions within this ...techniques and practices ... Voir le document complet
13
Big Data and Knowledge Management: How to Implement Conceptual Models in NoSQL Systems?
... quickly and easily modify data without rewriting tables when new data are ...structured and related in the database (Daniel, 2016); it is generally accepted that UML meets this requirement (Abello, ... Voir le document complet
7
Occupation and lymphoid malignancies: results from a French case-control study.
... LM and occupational exposures has been investigated in many countries, with various definitions of the diseases and ...stimulation and animal viruses in those ...occupations and NHL,(19) ... Voir le document complet
21
Management of bridge decks using stochastic deterioration models and multi-criteria optimization
... factor, and environmental category of each bridge required by the maintenance optimization model presented earlier are also ...traffic, and detour ...length, and larger surface ...portion, and ... Voir le document complet
12
Heterogeneous models matching for consistency management
... detection and enrichement of the correspondence model VII. C ONCLUSION AND PERSPECTIVES Our general research work addresses view-based complex information systems ...partial models related to a given ... Voir le document complet
14
Quel management des droits de propriété dans les business models ouverts ?
... du management des DPI dans les ...Le management des DPI est donc un élément essentiel de la construction d’un BM reposant sur l’utilisation équilibrée de ressources technologiques internes et ... Voir le document complet
22
Conflict management models in intercultural business
... In this thesis, we examine how the effects of conflict management strategies on evaluation of overall outcomes vary across the different cultural dyads of the East.. and the Wes[r] ... Voir le document complet
90
Les enjeux de la transition numérique et de l’innovation collaborative dans les mutations du travail et du management dans le secteur public
... du management dans les organisations privées et publiques, au moins au sein des sièges et des directions ...haut management contribuent à faciliter ces ... Voir le document complet
8
Integrating mechanistic and statistical deterioration models for effective bridge management
... safety and serviceability of existing structures and the assessment of their maintenance needs is a very complex ...deterioration and failure mechanisms and their interaction, which are very ... Voir le document complet
10
Airline-Driven Performance-Based Air Traffic Management: Game Theoretic Models and Multicriteria Evaluation
... variability and highest minimum values ...0.76 and 0.16 for metrics two, three and four, respectively) of all the ...1 and approach 3 (a weighted random choice of the user preferred ... Voir le document complet
38
Big Data and Knowledge Management: How to implement conceptual models in NoSQL systems?
... conceptual models in NoSQL ...diagram and HBase, the authors have proposed mapping rules to realize the transformation from the conceptual level to the physical ...conceptual models and graph ... Voir le document complet
7
Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies.
... monocytes and macrophages are activated, all resulting in a mass production of inflammatory cytokines, particularly interleukin (IL)-6 and interferon (IFN)- γ ( 111 ...monocyte and macrophage ... Voir le document complet
20
Les mutations RH : métiers, compétences, formations, La communication numérique demain : quels impacts sur la stratégie, le management et les ressources humaines
... Des techniques comme le crowd sourcing qui consiste à instaurer un dialogue avec le consommateur et à l’inciter à « créer » pour la marque, le rich média qui permet [r] ... Voir le document complet
36
Wind risk in forest growth, value and management models: the FOR-WIND project
... forest management units submitted to wind hazards at the decade time scale and including ...plantations and deciduous mixed beech forests as case ...environmental and soil mechanics, ... Voir le document complet
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