[PDF] Top 20 Mucosal-associated invariant T cells and disease
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Mucosal-associated invariant T cells and disease
... often associated with autoimmune diseases, dampens XIAP expression by MAIT ...MAIT cells in target tissues. As we mentioned above, MAIT cells have the propensity to migrate to inflamed tissues, ... Voir le document complet
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Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver
... fibrosis and cirrhosis include chronic alcohol con- sumption and non-alcoholic fatty liver disease associated with obesity and type-2 diabetes 3 , 4 ...ment, and liver ... Voir le document complet
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Biology of mouse mucosal-associated invariant T cells
... NKT and mucosal-associated invariant T (MAIT) cells express semi-invariant TCR and restriction by nonclassical MHC class Ib ...NKT and MAIT subsets is distinct. ... Voir le document complet
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en fr Mucosal Associated Invariant T (MAIT) cells induce inflammation, gut dysbiosis, and type 2 diabetes during obesity Les lymphocytes MAIT induisent l'inflammation, la dysbiose et le diabète de type 2 au cours de l'obésité
... Des analyses de la séquence des TCR exprimés par les LTαβ circulants ont mis en évidence l’existence de populations particulières de LTαβ avec des TCRαβ invariants parmi les LTαβ CD4-CD8- (DN) (Porcelli et al., 1993). A. ... Voir le document complet
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Human mucosal associated invariant T cells detect bacterially infected cells.
... MAIT Cells We next performed phenotypic analyses of Mtb-reactive MR1- restricted T-cell clones to determine if they shared properties of previously characterized MR1-restricted MAIT ...4) and uninfected ... Voir le document complet
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Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
... Jablaoui and Aïcha Kriaa for technical and methodology support and ...(EQU201903007779) and the European Foundation for the Study of Diabetes to ... Voir le document complet
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Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development
... liver disease, we analyzed the gene expression in liver biopsies from 216 patients with HCV-related early-stage liver cirrhosis 43 as well as in paired liver biopsies of patients with HCV-associated HCC 44 ... Voir le document complet
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Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation
... [ZO1 and claudin-1] integrity appeared to be preserved in distal colons of vorapaxar-treated mice that had also received TNBS [right lower panel of Supplementary Figure 5 ...ZO1 and claudin-1 disruption ... Voir le document complet
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Anti-microbial activity of Mucosal Associated Invariant T cells
... MAIT cells after birth suggested that the commensal flora induces MAIT cell maturation and ...MAIT cells are naïve and in small numbers 8 , which could result from a missing genetic element ... Voir le document complet
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Ontogeny of human mucosal-associated invariant T cells and related T cell subsets.
... childhood and after cord blood transplantation, is not related to a MAIT-cell intrinsic proliferative ...activation and proliferation of the MAIT cell pool (Chen et ...MAIT cells can adapt their ... Voir le document complet
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Alzheimer’s Disease-Associated Neurotoxic Peptide Amyloid-Β Impairs Base Excision Repair in Human Neuroblastoma Cells
... APP751-expressing cells was higher after H 2 O 2 ...SSBs and the oxidized purine-associated DNA repair pathway might also be affected by ...APP751-expressing cells and mock ... Voir le document complet
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NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27
... distribution, and reproduction in any medium, provided the original author and source are ...NK cells against tumor-associated endothelial cells isolated from bone marrow aspirates of ... Voir le document complet
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Pathways systematically associated to Hirschsprung's disease.
... Hirschsprung’s disease to carry out a multi-population PBA study that validate the initial functional ...the disease, being of special interest those terms related to signal transduc- tion, such as the ones ... Voir le document complet
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Development of Disease - Bacterial Toxins and their Interaction with Host Cells
... TeTx and BoNTS also share com- mon mechanisms of ...peptide and are classically excreted by the general Sec secretion ...epithelial cells and the migration of the BoNTs and TeTx in the ... Voir le document complet
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Influenza A virus infection of intestinal epithelial cells enhances the adhesion ability of Crohn's disease associated Escherichia coli strains
... Crohn's disease (CD), favor, among the commensal species of microbiota, the enrichment in Escherichia ...epithelial cells could influence the adhesiveness of different Escherichia coli strains isolated from ... Voir le document complet
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Tomato root microbiota and Phytophthora parasitica-associated disease
... We identified one Pseudomonas phylotype (exhibiting antibiosis activity), which significantly increased symp- tom severity on treated plantlets. When inoculated alone (without P. parasitica), the phylotype never provoked ... Voir le document complet
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Variants associated with Gaucher disease in multiple system atrophy
... and a–synuclein have been investigated ...stem cells from PD patients with GD variants revealed that GBA activity was reduced, glucosyl- ceramide and a–synuclein levels were increased, and ... Voir le document complet
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Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation.
... βII and γ), novel (nPKC: δ, ε, θ, η, μ) and atypical (aPKC: λ,ζ) PKC isozymes [150] according to their modes of ...nPKC-θ and aPKC-ζ signaling by hypoxia-mediated TJ proteins results in ... Voir le document complet
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Biomechanics of red blood cells in human spleen and consequences for physiology and disease
... condition associated with severe infectious, circulatory, and proliferative complications ...sickle-cell disease (39) and patients suffering from an array of acute or chronic medical ... Voir le document complet
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Treatments for Crohn's Disease-Associated Bowel Damage: A Systematic Review.
... epithelial cells are critical drivers of fibrogenic process via the acquisition of a profibrotic ...Epithelial cells are characterized by an inherent plas- ...epithelial cells take on the typical ... Voir le document complet
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