[PDF] Top 20 Mucins and tumor resistance to chemotherapeutic drugs

... membrane-bound mucins is closely linked to the number and length of O-glycosidic chains worn by ...used to inhibit the synthesis of mucin O- glycosylation in cellular ...CAPAN-1 and ... Voir le document complet

... network and stable hydrogel. The cell casting procedure is simple and enables a rapid and efficient encapsulation of ovarian cancer cells within RADA16-I peptide ...activities and maintain the ... Voir le document complet

... safety and tolera- bility ...tant to chemotherapeutic agents such as paclitaxel than wild-type counterparts (see also Supplemental ...sensitivity to paclitaxel, and this effect was ... Voir le document complet

... SUMMARY Chemotherapeutic drugs used in the treatment of acute myeloid leukemias (AMLs) are thought to induce cancer cell death through the generation of DNA double-strand ...DDIT3, and helps ... Voir le document complet

... according to at least two major effects: • Cell ...response to drugs. A typical example is the release of resistance proteins such as P-gp and other ABC transporters (ATP Binding ... Voir le document complet

... drive tumor progression has revolutionized the clinical management of non-small cell lung cancer ...erlotinib, and afatinib, have been shown to improve progression-free survival and were ... Voir le document complet

... Enhancing chemotherapeutic efficacy by targeting pro-survival signaling The idea that tissue damage associated with chemotherapy can activate a paracrine pro- survival secretory program suggests that inhibition of ... Voir le document complet

... α and CA IX protein levels and in the decreased migration) also in chemoresistant cell lines under hypoxic conditions, namely in cisplatin-resistant A2780/CP cells and adriamycin-resistant A2780/ADR ... Voir le document complet

... (3–5%) and the survival curve at five years is very short (six months) ...related to a lack of efficient therapeutic tools and early diagnostic markers ...10% to 15% of patients are considered ... Voir le document complet

... MreC and His 8 -MreD (compare Figure 35 and Figure ...tend to confirm that the proteins observed in the elution of the purification of the complex including RodA, PBP2b, MreC and MreD are ... Voir le document complet

... crucial to screen new therapeutic agents for acute myeloid leukemia ...easy to establish and manipulate in the ...was to develop robust xenograft models of human AML using well-characterized ... Voir le document complet

... The possibility exists, therefore, that the cis-DDP G*G*, A*G*, and G*TG* adducts are repaired at different rates by the UvrABC system, thereby accounting for the observed differen[r] ... Voir le document complet

... contributor to intestinal innate immunity (Figure 1). It creates physical and chemical barriers that protect the host (Peterson and Artis, ...cells, and Paneth cells, all of which are derived ... Voir le document complet

... Circulating tumor cell (CTC) detection and numeration are becoming part of the common clinical practice, especially for breast, colon, and prostate ...tried to improve CTC recovery rate by ... Voir le document complet

... A1401G: resistance of high level to AMK and KAN, resistance of different levels to CAP rrs C1402T: resistance of high level to CAP, resistance to KAN with ... Voir le document complet

... and around the resection margin for such a long ...reluctant to address this concern for the same reasons it was difficult to accept that contamination transmitted via surgeons’ hands could spread ... Voir le document complet

... susceptibility to antimicrobial treatments is well- known and is often the result of a combination of transfer limita- tion, the consumption/neutralization of the antibiotics by biofilm matrix components, ... Voir le document complet

... used to treat pouchitis (Sartor, 2004) and has been shown to decrease postoperative recurrence in CD patients (Rutgeerts et ...azathioprine, and led to a reduction in 1-year endoscopic ... Voir le document complet

... cells and in some tumor cells 2 ...leads to Na + and Ca 2+ influx, and, after prolonged activation, to the opening of a larger con- ductance membrane ...is to induce cell ... Voir le document complet

... Only thé boys demonstrate a significant and systematic corrélation between thé number of incidents linked to drug use in 1992 and thé behaviour connected to each of thé four main catégor[r] ... Voir le document complet