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[PDF] Top 20 Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection

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Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection

Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection

... whether in vivo pDC professional IFN-I production necessitates positive feedback from these cytokines is ...nature of the TLR7/9 ligands ...stimulated in vivo with synthetic TLR7/9 ... Voir le document complet

20

Plasmacytoid, conventional, and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation

Plasmacytoid, conventional, and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation

... impact of MCMV infection on DC subsets early after virus inoculation, we profiled the gene expression pro- grams of splenic pDCs, CD8 α + cDCs, and CD11b + cDCs isolated from control animals (q ... Voir le document complet

11

Virosome-mediated delivery of tumor antigen to plasmacytoid dendritic cells.

Virosome-mediated delivery of tumor antigen to plasmacytoid dendritic cells.

... the plasmacytoid DCs. During viral infection, plasmacytoid dendritic cells (PDC) are known to be highly efficient producers of type I IFN (13, ...produce a large ... Voir le document complet

21

TLR2/1 Orchestrate Human Plasmacytoid Dendritic Cells Response to Gram+ Bacteria

TLR2/1 Orchestrate Human Plasmacytoid Dendritic Cells Response to Gram+ Bacteria

... differentiation in the dendritic ...expression of MHC-II complex, CD80 and CD86, thus stimulating their capacity to cross present antigens to CD8+ T-cells and their migration through the lymph nodes ... Voir le document complet

215

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

... B cell receptor (BCR)-like pathway involv- ing Syk, Mek-Erk1/2, and BLNK [ 6 , 10 ...production of IFN and proinflammatory cytokines [ 6 , 7 , 10 ...mechanism of IFN control is hijacked in the ... Voir le document complet

12

Sustained IFN-I Expression during Established Persistent Viral Infection: A "Bad Seed" for Protective Immunity

Sustained IFN-I Expression during Established Persistent Viral Infection: A "Bad Seed" for Protective Immunity

... one of the primary immune defenses against ...other molecular mechanisms that are central to eliciting protective immune responses, IFN-I expression is subject to homeostatic controls that regulate cytokine ... Voir le document complet

11

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en fr Plasmacytoid dendritic cells and viral infections : physiopathologic role and vaccinal potency Cellules dendritiques plasmocytoïdes et infections virales : rôle physiopathologique et potentiel vaccinal

... il a été démontré dans un modèle de souris portant une tumeur cutanée (mélanome B16), que des pDCs activées par des ligands de TLR9 directement injectées dans la tumeur, pouvaient produire des chemokines (CCL3, ... Voir le document complet

148

Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses

Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses

... In vivo models of immunization and in vitro secondary challenge ...rejected in 7 ...subjected in vitro to secondary challenge (mixed leukocyte reaction [MLR]) with T-cell ... Voir le document complet

13

Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer.

Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer.

... melanomas in palliative therapy have been reported ...use of Imiquimod as a first intention therapy for the treatment of 30 lentigo maligna that were not easily accessible through surgery ... Voir le document complet

24

Subversion of the B-cell compartment during parasitic, bacterial, and viral infections

Subversion of the B-cell compartment during parasitic, bacterial, and viral infections

... other in- hibitory receptors and are unresponsive to BCR trigger- ing ...play a role in Ab or cytokine ...effects of chronic infec- tion or inflammation ...binding of recombinant gp120 ... Voir le document complet

11

Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo

Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo

... reproduction in any medium, provided the original author and source are ...is a pediatric liver cancer with defined molecular alterations driving its ...features of HBL in patients. ... Voir le document complet

15

Sensing and signalling viral infection in drosophila

Sensing and signalling viral infection in drosophila

... signalling viral infection in Drosophila Juliette Schneider & Jean-Luc Imler Highlights siRNAs and miRNAs, but not piRNAs, regulate viral infection in ...immunity in ... Voir le document complet

39

A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis

A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis

... dosed in the plasma of the different groups, by two methods: S Flow and Tri ...plots of cytokines differentially expressed and grouped based on the description of each sub ...by a post ... Voir le document complet

65

IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.

IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.

... involved in inducing ...IRF-5 in monocytes of systemic lupus erythematosus (SLE) patients ( Stone et ...occurs during chronic VL ( Smelt et ...(SN) of apoptotic splenocytes previously ... Voir le document complet

14

Claudins in viral infection: from entry to spread

Claudins in viral infection: from entry to spread

... permeability of tight ...comprised of intracellular N-terminal and C-terminal tails, four transmembrane helices, two extracellular loops (large ECL1 and small ECL2) and one cytoplasmic loop (Figure ...have ... Voir le document complet

31

Differential levels of IFNα subtypes in autoimmunity and viral infection

Differential levels of IFNα subtypes in autoimmunity and viral infection

... cell type) with different TLR ligands and quantified IFN α in the super- natant with both ...plus a Null control for 22 h using concentrations previously defined to be within the linear range ... Voir le document complet

13

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS.

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS.

... To further identify translationally regulated mRNAs in maturing moDC, expression levels of all polysome-bound mRNAs were compared by microarray analysis Affymetrix U133 Plus 2.0 GeneChip[r] ... Voir le document complet

13

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon-α inhibition

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon-α inhibition

... T cell coculture system, pDCs were cultured for 24 h with ...3 in the presence of 10 ng/mL IL-3, simultaneously activated with CpG-A or CpG-B, and washed twice before ...T cell ... Voir le document complet

13

Host–virus interactions during hepatitis C virus infection : a complex and dynamic molecular biosystem

Host–virus interactions during hepatitis C virus infection : a complex and dynamic molecular biosystem

... analysis of kinetics by following their movements. With the help of fusion proteins, the membranous web was identified to exist in two distinct populations and their physical movements pertain to ... Voir le document complet

13

Functional dissection of the apicomplexan glideosome molecular architecture.

Functional dissection of the apicomplexan glideosome molecular architecture.

... tion during gliding or invasion, respectively. GAP45 might consti- tute a fluid bridge between the IMC and PM such that the cohesion of the pellicle is ...as a spring between the two membranes ... Voir le document complet

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