[PDF] Top 20 Metformin: From Mechanisms of Action to Therapies
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Metformin: From Mechanisms of Action to Therapies
... independently of an increase in the AMP/ATP ratio(Cao et ...does metformin activate AMPK without affecting energy ...that metformin activates AMPK indirectly, secondary to the inhibition ... Voir le document complet
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Metformin: From Mechanisms of Action to Therapies
... independently of an increase in the AMP/ATP ratio(Cao et ...does metformin activate AMPK without affecting energy ...that metformin activates AMPK indirectly, secondary to the inhibition ... Voir le document complet
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Cellular and molecular mechanisms of metformin: an overview.
... Conclusion Metformin is currently used as an antihyperglycemic ...effect of this drug is to decrease hepatic glucose production through a mild inhibition of the mitochondrial respiratory-chain ... Voir le document complet
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Defining principles of combination drug mechanisms of action
... combination therapies have been argued to act via the minimization of acquired resistance, the existence of cell-intrinsic drug synergy, or the maximization of the cumulative drug ... Voir le document complet
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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
... effect of metformin on insulin sensitivity has been reported in skeletal muscle 15,16 , although not in all studies 17 .... Metformin treatment is accompanied by insulin‐stimulated systemic glucose ... Voir le document complet
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Therapy: Metformin takes a new route to clinical efficacy.
... signal to release GLP-1 that is induced by metformin is relayed by the activation of GLP1R on vagal afferent neurons through effects on a neuronal ...This action was demonstrated by ... Voir le document complet
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Use of molecular techniques in elucidating the action mechanisms of fungal biocontrol agents
... or to non-involvement of the gene in biocontrol. Integration of a foreign DNA fragment to inactivate or overexpress a gene is a useful tool for refining the analysis of the involvement ... Voir le document complet
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Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics
... 80–85% of patients with non-operable pancreatic cancer with locoregional or distant metastases (mainly liver and lung) chemotherapy can be used to improve quality of life and survival by relieving ... Voir le document complet
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From semantic web data to inform-action: a means to an end
... characteristics to be potentially multiform (the message can be conveyed by images, videos, ...delivered to end-users are delimited by the possibilities of interactions that have been made available ... Voir le document complet
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en fr Study of extracorporeal photopheresis mechanisms of action Etude des mécanismes d'action de la photochimiothérapie extracorporelle
... reinfusion of photochemical modified mononuclear ...treatment of CTCL, in GvHD and in others T-cell mediated diseases (organ transplant rejection and auto-immune ...years, mechanisms of ... Voir le document complet
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Photo-triggered polymer nanomedicines: From molecular mechanisms to therapeutic applications
... field of biomedicine, which aims to use nanotechnology in order to find innovative systems for diagnosis and ...development of efficient drug delivery systems (DDS). The efficacy of a ... Voir le document complet
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Machine-learning assisted phenotyping: From fungal morphology to mode of action hypothesis
... GLOBAL parameters: skeleton length variance, skeleton total length, object number, gradient threshold. SPECIFIC parameters : weighted length, skeleton length, distance on skeleton mean, distance on skeleton variance, ... Voir le document complet
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Regulatory T Cell-Enhancing Therapies to Treat Atherosclerosis
... derived from Apoe −/− mice exhibit a highly restricted T cell receptor (TCR)α/β repertoire [ 19 ...shown to protect against atheroscle- rosis [ 20 ...cells from human atherosclerotic plaques respond ... Voir le document complet
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Innovative strategies for intervertebral disc regenerative medicine: From cell therapies to multiscale delivery systems
... Innovative strategies for intervertebral disc regenerative medicine: from cell therapies to multiscale delivery systems.. Nina Henry a,b,c , Johann Clouet a,c,d,e , Jean Le Bideau b , C[r] ... Voir le document complet
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Editorial: Metformin: Beyond Diabetes
... Diabetes Metformin, a member of the family of biguanides, is one of the most prescribed medications in the US and Europe and remains the first-line treatment for type 2 Diabetes (T2D) ...given ... Voir le document complet
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The delivery of advanced therapies to patients: challenges and solutions
... Therapeutic area Orthopaedics Gastro- enterology Orthopaedics Oncology Ophtalmology Oncology Immunology Graft vs. host Orthopaedics Gastro-enterology Year of authorisation 2009 2012 2013 2013 2015 2015 2016 2016 ... Voir le document complet
2
Call to Action
... Commission of Inquiry into Certain Events at the Prison for Women in Kingston.. Con Game.[r] ... Voir le document complet
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Antipyretic and antinociceptive effects of Nauclea latifolia root decoction and possible mechanisms of action.
... duration of rearing and grooming in the bicuculline-induced behavioral excitation ...animals to evaluate the central depressant properties of the ...level of excitability of the central ... Voir le document complet
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Anthocyanins and endothelial protection: Identification of cellular and multi-targeted molecular mechanisms of action
... Olivier.le-bacquer@inra.fr mTOR (mammalian Target of rapamycin) est un nœud métabolique qui en réponse aux nutriments et facteurs de croissance régule de nombreux processus cellulaires. Une suractivation de mTOR ... Voir le document complet
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Mechanisms of action of Ru( ii ) polypyridyl complexes in living cells upon light irradiation
... damage of purines in ...images of different cell lines such as U2OS (human bone osteosarcoma), MCF-7 (mammary gland adenocarcinoma) and RPE-1 (normal retina pigmented epithelium) confirmed that the complex ... Voir le document complet
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