[PDF] Top 20 Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy

... Maintaining the cellular proteostasis is of the upmost importance for cells ...health. The UPS and the ALS act in an orchestrated manner to guarantee the correct ... Voir le document complet

... because of its utmost importance for protein homeostasis (proteostasis). The two major intracellular proteolytic pathways are the ubiquitin-proteasome and the autophagy-lysosome systems which ... Voir le document complet

... understand the regulation of the crosstalk between UPS and ALS in leukaemia, we investigated the role of proteaphagy which is known to be activated ... Voir le document complet

... shortcoming of a DMU is that it still misses the temporal aspect; that is, the 3D model represents reality at a given instant t, with no least information about how the product will look like ... Voir le document complet

... Thus, the impaired functions of Gi proteins results in developing hypertension and associated ...not of Goα and Gsα are overexpressed in heart and aorta from different hypertensive rat models ... Voir le document complet

... homogenous of degree zero in all goals. That is, if all targets are doubled, the emulation factors for each of the rivals, remain ...on the process. One may be tempted to argue that ... Voir le document complet

... Analysis of convergence and stability for adaptive algo- rithms can pose difficult problems but are crucial in adaptive signal ...havior of the feedback structure for two-channel adaptive noise ... Voir le document complet

... spectrum of focal epilepsies, but the underlying pathogenic mechanisms are still largely ...in the brain, increased drug-induced seizure susceptibility, general hypoactivity and premature ... Voir le document complet

... Tammet, H. and Kulmala, M.: Simulation tool for atmospheric aerosol nucleation bursts, J. Aerosol Sci., 36, 173–196, 2005. Wagner, R., Yan, C., Lehtipalo, K., Duplissy, J., Nieminen, T., Kan- gasluoma, J., Ahonen, L. R., ... Voir le document complet

... family of five members (PHYA-PHYE) encodes the phytochromes (Bae and Choi, 2008), which have positive ( phyB-phyE) and negative ( phyA) roles in controlling SAS-driven development (Franklin, 2008; ... Voir le document complet

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 ... Voir le document complet

... that the interaction of macrophages and tumor cells is not only important for progression at the primary tumor site but also for the promotion and differentiation of CTCs [ 77 ... Voir le document complet

... in the presence of Pks13 and FadD32. The whole reaction prod- ucts were deposited on silica gel and analyzed by TLC (eluent: CH 2 Cl 2 ...and the spots were visualized by UV detection; lanes ... Voir le document complet

... member of the glypican family, which contains a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol ...a role in the control of growth and cell ... Voir le document complet

... in the ovary results both in down-regulation and up- regulation of target gene expression, indicating the dLsd1 acts both as a co-repressor and as a ...to the fact that the tran- ... Voir le document complet

... sport: The French version of the Behavioral Regulation in Exercise Questionnaire-2 (BREQ-2; Markland and Tobin, validated in French by Chamberland, Miquelon and Gareau [32,34] was ...used. The ... Voir le document complet

... In the original setting from [ 11 ], gene expressions were discrete and could take only two values, − 1 for no expression and 1 for an expressed gene, f ( x ) was thus a step function ( f ( x < 0 ) = − 1; f ( 0 ... Voir le document complet

... than the natural vegetation they replace in these regions. The over- all effect of land use/cover change for each model, there- fore, is often the aggregated result over many regions that can ... Voir le document complet

... guration of the relationship between regulatory authori- ties and firms and of the “ways of knowing” under the authorization ...case, the authorization procedure signals a ... Voir le document complet

... rot of banana fruits is caused by a complex of fungal pathogens, the most common of which is Colletotrichum musae, and is one of the main quality defects of exported ... Voir le document complet