[PDF] Top 20 Lysophosphatidic acid synthesis and release.

... that lysophosphatidic acid (LPA) is not only a key intermediate in glycerolipid synthesis but also a bioactive phospholipid, was brought by Vogt in 1969 ...neurotransmitter release, cell ... Voir le document complet

... in synthesis of the bioactive phospholipid, lysophosphatidic acid ...conditioned-medium and identified as the type II ecto-nucleotide pyrophosphatase phosphodiesterase: autotaxin ... Voir le document complet

... acids and phospholipids Stable isotope labelling using U- 13 C-glucose or U- 13 C-acetate (Cambridge Isotope Laborato- ries, USA), lipid extraction, and GC-MS analysis was performed as previously described ... Voir le document complet

... In order to study extra-cellular production of LPA, 3T3F442A adipocytes (3 cm diameter plate) or human adipose tissue explants (0.7 g) were incubated in 1 ml of sterile Hepes-buffer (HB) (118 mM NaCl, 6 mM KCl, 1 mM CaCl ... Voir le document complet

... invasion and proliferation (13, 31, 32). In the present study, MDA-BO2 cells and transfectants did not directly produce LPA, nor did they express ...34), and more recently, platelet aggregation was ... Voir le document complet

... expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-beta, J Am Soc Nephrol 8 (1997) ...folic acid-induced renal inflammatory injury in ... Voir le document complet

... spreading and proliferation of 3T3F442A ...media and microdialy- ...only lysophosphatidic acid (LPA) was able to induce spreading and proliferation of 3T3F442A preadipo- ...sustained, ... Voir le document complet

... the release of free HPOs and hydroxy fatty acid from esterified pool of oxylipins that accumulate at elevated levels prior to fungal ...linolenic acid released by phospholipase ...2001), ... Voir le document complet

... neutrophils and other leukocyte subtypes including macrophages/monocytes and lymphocytes through activation of two LPA receptors, LPA1 and LPA3 ...the synthesis of various chemokines/cytokines ... Voir le document complet

... LPA synthesis by adipocytes is the hydrolysis of lysophosphatidylcholine by a lysophospholipase D secreted by adipocytes 1 (manuscript in ...cells, and able to degrade exogenously added glycerol- or ... Voir le document complet

... activation and proliferation is a result of complex and well-orchestrated set of events when, in response to severe liver injury, hepatic cells release growth factors, cytokines and chemokines ... Voir le document complet

... control and/or regulate PPAR γ activity and adipogenesis is of major interest to understand normal and pathologic growth of adipose ...glucocorticoids and thyroid hormone, ….) are known to ... Voir le document complet

... 0.25% and 0.5% deformation. Stress-strain characteristics Breaking stress and elongation at break were evaluated using an Instron® Model 3367 series dual column system (Norwood, USA) with a load capacity 5 ... Voir le document complet

... Organic Acid Lignin-based Polyurethane Films: Synthesis Parameter Optimization Laurence Llovera, a Bouchra Benjelloun-Mlayah, a, * and Michel Delmas a,b Polyurethane (PU) films were prepared by ... Voir le document complet

... temperatures and became more important at higher ...orthophosphoric acid and therefore favored the ...500 and 600 °C, existed in solid phase and could isolate the sodium chloride core ... Voir le document complet

... 13) and that acid was required for the reaction to proceed to ...(p-tolylbenzenesulfonic acid (p-TSA); data not shown) or a Lewis acid (Sc III ... Voir le document complet

... 3D and 4C show the simple 1 H and 13 C NMR spectra resulting from symmetric, highly substituted repeat units of SPFEEKK–COOH ...0 and H22 0 could still be observed in the ...fluorenyl and main ... Voir le document complet

... bile acid pool is more hydrophobic as compared to ...CA synthesis at the expense of dihydroxyl- ated CDCA, would result in a more hydrophilic, rather than a more hydrophobic, bile acid pool in ... Voir le document complet

... DHA and monoisopropyl phloroglucinol 9b was evaluated under the same conditions (pretreatment design), and this mixture was found to cause toxicity comparable to that observed with DHA alone (Table 1, ... Voir le document complet

... range and had lower cellular internalization than the other two ...bile acid-based drug delivery system on drug resistant cancer cell lines and cytotoxic drugs with poor cellular ... Voir le document complet