Haut PDF Lysophosphatidic acid synthesis and release.
Lysophosphatidic acid synthesis and release.
... that lysophosphatidic acid (LPA) is not only a key intermediate in glycerolipid synthesis but also a bioactive phospholipid, was brought by Vogt in 1969 ...neurotransmitter release, cell ...
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Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity.
... in synthesis of the bioactive phospholipid, lysophosphatidic acid ...conditioned-medium and identified as the type II ecto-nucleotide pyrophosphatase phosphodiesterase: autotaxin ...
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Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase
... acids and phospholipids Stable isotope labelling using U- 13 C-glucose or U- 13 C-acetate (Cambridge Isotope Laborato- ries, USA), lipid extraction, and GC-MS analysis was performed as previously described ...
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Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis.
... In order to study extra-cellular production of LPA, 3T3F442A adipocytes (3 cm diameter plate) or human adipose tissue explants (0.7 g) were incubated in 1 ml of sterile Hepes-buffer (HB) (118 mM NaCl, 6 mM KCl, 1 mM CaCl ...
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Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.
... invasion and proliferation (13, 31, 32). In the present study, MDA-BO2 cells and transfectants did not directly produce LPA, nor did they express ...34), and more recently, platelet aggregation was ...
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Lysophosphatidic acid and renal fibrosis.
... expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-beta, J Am Soc Nephrol 8 (1997) ...folic acid-induced renal inflammatory injury in ...
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Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth.
... spreading and proliferation of 3T3F442A ...media and microdialy- ...only lysophosphatidic acid (LPA) was able to induce spreading and proliferation of 3T3F442A preadipo- ...sustained, ...
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Reprogramming of fatty acid and oxylipin synthesis in rhizobacteria-induced systemic resistance in tomato
... the release of free HPOs and hydroxy fatty acid from esterified pool of oxylipins that accumulate at elevated levels prior to fungal ...linolenic acid released by phospholipase ...2001), ...
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Experimental study on the role of lysophosphatidic acid in mediating cytokine/chemokine production and on the signaling pathways involved in inflammatory arthritis
... neutrophils and other leukocyte subtypes including macrophages/monocytes and lymphocytes through activation of two LPA receptors, LPA1 and LPA3 ...the synthesis of various chemokines/cytokines ...
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Expression of ectolipid phosphate phosphohydrolases in 3T3F442A preadipocytes and adipocytes. Involvement in the control of lysophosphatidic acid production.
... LPA synthesis by adipocytes is the hydrolysis of lysophosphatidylcholine by a lysophospholipase D secreted by adipocytes 1 (manuscript in ...cells, and able to degrade exogenously added glycerol- or ...
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Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury.
... activation and proliferation is a result of complex and well-orchestrated set of events when, in response to severe liver injury, hepatic cells release growth factors, cytokines and chemokines ...
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Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2.
... control and/or regulate PPAR γ activity and adipogenesis is of major interest to understand normal and pathologic growth of adipose ...glucocorticoids and thyroid hormone, ….) are known to ...
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Organic acid lignin-based polyurethane films: synthesis parameter optimization
... 0.25% and 0.5% deformation. Stress-strain characteristics Breaking stress and elongation at break were evaluated using an Instron® Model 3367 series dual column system (Norwood, USA) with a load capacity 5 ...
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Organic acid lignin-based polyurethane films: synthesis parameter optimization
... Organic Acid Lignin-based Polyurethane Films: Synthesis Parameter Optimization Laurence Llovera, a Bouchra Benjelloun-Mlayah, a, * and Michel Delmas a,b Polyurethane (PU) films were prepared by ...
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One-Step Synthesis of Sodium Trimetaphosphate (Na3P3O9) from Sodium Chloride and Orthophosphoric Acid
... temperatures and became more important at higher ...orthophosphoric acid and therefore favored the ...500 and 600 °C, existed in solid phase and could isolate the sodium chloride core ...
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Metal-free, acid-catalyzed ortho -directed synthesis of anthranilic acid derivatives using carbodiimides
... 13) and that acid was required for the reaction to proceed to ...(p-tolylbenzenesulfonic acid (p-TSA); data not shown) or a Lewis acid (Sc III ...
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Poly(aryl ether ketone)s with carboxylic acid groups: synthesis, sulfonation and crosslinking
... 3D and 4C show the simple 1 H and 13 C NMR spectra resulting from symmetric, highly substituted repeat units of SPFEEKK–COOH ...0 and H22 0 could still be observed in the ...fluorenyl and main ...
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Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice
... bile acid pool is more hydrophobic as compared to ...CA synthesis at the expense of dihydroxyl- ated CDCA, would result in a more hydrophilic, rather than a more hydrophobic, bile acid pool in ...
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Synthesis and Evaluation of Polyunsaturated Fatty Acid-Phenol Conjugates as Anti-Carbonyl-Stress Lipophenols
... DHA and monoisopropyl phloroglucinol 9b was evaluated under the same conditions (pretreatment design), and this mixture was found to cause toxicity comparable to that observed with DHA alone (Table 1, ...
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Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
... range and had lower cellular internalization than the other two ...bile acid-based drug delivery system on drug resistant cancer cell lines and cytotoxic drugs with poor cellular ...
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