[PDF] Top 20 Longitudinal immunomonitoring following Tocilizumab in rheumatoid arthritis

... Access Longitudinal immunomonitoring following Tocilizumab in rheumatoid arthritis Yves-Marie Pers 1,2* , Pascale Louis-Plence 1 , Pierre Portales 3 , Julie Quentin 1 , ... Voir le document complet

... inhibitor tocilizumab, including significantly increased levels of total and LDL cholesterol [ 68 – 70 ...and tocilizumab in terms of CV risk [ 71 – 73 ...differences in the risk of MACE ... Voir le document complet

... the following terms: ”rheumatoid arthritis and (discordance or discrepancy) and global ...or longitudinal studies) published in English or French were ...studies in juvenile ... Voir le document complet

... Affiliations: 1 APHP, Hôpital Bichat, Service de Rhumatologie, DHU FIRE, Paris, France. 2 Université Paris Diderot, Sorbonne Paris Cité, Paris, France. 3 APHP, Hôpital Bichat, Service de Pneumologie A, DHU FIRE, Paris, ... Voir le document complet

... tured for 21 days either non-stimulated (-t-), or treated with pro-inflammatory cytokines 10 ng/ml oncostatin M (OSM) in combination with 20 ng/ml tumour necrosis factor alpha (TNFα) (- 䉬-). The conditioned medium ... Voir le document complet

... trials in RA did not show any differ- ences for body composition after 6 months and 1 year of ...increased in fat mass with preservation of muscle mass was observed with in fliximab during long-term ... Voir le document complet

... reported in patients with Crohn’s disease and RA receiv- ing anti-TNF treatment ...reported in those patients. Similar observations were made in an HIV popu- lation where a secondary cell-mediated ... Voir le document complet

... differences in age at onset of DB and genetic background appear to have a significant, independent, and strong effect on ...mortality. In addition, our patients were selected from families with a history of ... Voir le document complet

... effect in curative settings ...disease. In the same manner, the dose of 10 5 CD4CD49b + or CD25 + cells reverse clinical symptom with a lack of efficacy of higher ...investigated in inflammatory ... Voir le document complet

... MMP9. In a murine model of arthritis, specific depletion of FAPα + THY1 + FLS led to inflammation decrease, whereas depletion of THY1 − FLS resulted in bone protection, suggesting that these cell ... Voir le document complet

... (VDR) in rheumatoid arthritis ...genotyped in 100 RA French nuclear families (set 1) and 100 additional French nuclear families for replication (set ...0.01) in set 1. Furthermore, the ... Voir le document complet

... patients in a case– control ...from arthritis versus 41% in the control group (P < ...frequent in ACPA-positive ASS patients (87% vs 11%, P < ...monoxide in ACPA–ASS patients, ... Voir le document complet

... patients in LDA or remis- sion and proportion of patients with structural damage) were compared in each arm by Student’s ...patients in the initial M-arm and for patients in the initial S-arm ... Voir le document complet

... sustained remission, and are associated with systemic com- plications. Most importantly, prolonged delay in achieving adequate disease control impacts quality of life for RA patients. Current classification of ... Voir le document complet

... of rheumatoid arthritis (RA) is not yet clearly ...RA. Rheumatoid factor (RF), another type of autoreactive antibody could also be detected and is associated to disease severity, like ACPA ...[1]. ... Voir le document complet

... fever) in <15% of patients ( 21 ...cord in which focal lymphocytic infiltration leads to damage of myelin and axon ( 23 ...lesions in 83.3% of the subjects followed ( 22 ). In another ... Voir le document complet

... citrullination in vitro ...involved in the trans- duction of mitogenic signals from the cell membrane to the ...step in the activation of the MAPK cascade. Following RAS activation, BRAF is ... Voir le document complet

... of rheumatoid arthritis (RA), occurring in *10% of ...emerged in recent series as a key prognos- tic factor including survival [ 1 ...drugs in these conditions [ 2 , 3 ...use in ... Voir le document complet

... Discussion In the present study we validated the classification of HLA- DRB1 SE alleles in RA proposed by Tezenas du Montcel and coworkers ...results in a risk genotype hierarchy, for which we ... Voir le document complet

... used in rheumatoid arthritis (RA) routine clinical ...PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score ... Voir le document complet