[PDF] Top 20 Intracellular galectins in cancer cells: Potential new targets for therapy (Review)
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Intracellular galectins in cancer cells: Potential new targets for therapy (Review)
... that galectins were involved in cancer was published more than 25 years ago when it was observed that they were differently regulated in normal and cancer ...of galectins ... Voir le document complet
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Differentiation of Cancer Stem Cells by Using Synthetic Small Molecules: Toward New Therapeutic Strategies against Therapy Resistance
... CSCs in order to induce their differentiation, inhibit their tumorigenicity and sensitize them to classical ...these cells represent an efficient and promising strategy, but their clinical applications ... Voir le document complet
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Estrogen receptor signaling as a target for novel breast cancer therapeutics.: new targets in estradiol receptor-positive breast cancers
... synthesis in the ribosomes, all steroid receptors are associated in a multiprotein chaperone complex organized around Hsp90 [7] which helps to fold client ...necessary for ER and other NRs to display ... Voir le document complet
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Externalized Keratin 8: A Target at the Interface of Microenvironment and Intracellular Signaling in Colorectal Cancer Cells
... of cancer cells of proteins, which are normally expressed in the intracellular ...druggable targets for cancer therapy, the mechanisms via which they impact ... Voir le document complet
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Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer
... Breast cancer (BC) is a heterogeneous disease that differs at the genetic, histopathological and clinical levels [ 12 ...treatments for ER + and HER2 + BC, respectively, in combination with ... Voir le document complet
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Antibody targeting of claudin-1 as a potential colorectal cancer therapy
... overexpression in all tested pri- mary tumor samples from patients with mCRC supports the hypothesis that CLDN1 could represent a target for antibody-based ...expression in the new CRC ... Voir le document complet
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Investigation of antiangiogenic tumor therapy potential of microencapsulated HEK293 VEGF165b producing cells
... conventional cancer therapy. For instance, one approved angiogenesis inhibitor can be used in different types of tumors, as solid tumors are angiogenesis ...Antiangiogenesis targets ... Voir le document complet
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A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells
... anti-bCSC therapy that selec- tively target bCSCs while mainly sparing actively dividing differenti- ated cancer cells, ending up with limited short-term effect on tumor growth (Ginestier et al, ... Voir le document complet
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Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy
... evaluated for their ability to transport diverse cargos into cells, tissues, and ...involved in anti-apoptotic signalling, including (i) the peptide shepherdin mimicking a small domain of the ... Voir le document complet
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Anti-HER2 vaccines: new prospects for breast cancer therapy.
... involved in the generation of immunomodulators, such as Indoleamine 2,3- dioxygenase (IDO) (which is produced by dendritic cells (115) and by many tumor cells) (116), PGE-2 (117) and VEGF which can ... Voir le document complet
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Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines
... accurately for higher [Na + ] ...the cells with time that has been observed in this ...from intracellular medium due to its relatively small ... Voir le document complet
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Serum Soluble HLA-E in Melanoma: A New Potential Immune-Related Marker in Cancer
... tumor cells could contribute for immunosurveillance ...investigated. In support of a potential immunoregulatory fonction, Coupel et ...endothelial cells from NK-mediated cell lysis ... Voir le document complet
10
Plasminogen Activator System and Breast Cancer: Potential Role in Therapy Decision Making and Precision Medicine
... serine protease, uPA, membrane-linked receptor uPAR, and two serpin inhibitors, PAI-1 and PAI-2. uPA is a 53-kDa serine protease initially synthesized as a catalytically inactive single chain polypeptide. pro-uPA whose ... Voir le document complet
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Organometallic compounds of osmium for cancer therapy
... # Scheme#2.2#Synthetic#route#to#triosmium#carbonyl#clusters#with#nitrile#ligands.# The# synthesis# of# 3a( was# carried# out# similarly# to# the# method# to# synthesize# 1,# by# heating# ... Voir le document complet
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Characterization of novel epigenetic targets in ovarian cancer
... recombination. For example, methylation of LINE-1 (long interspersed nucleotide elements) plays one important role in maintenance of genomic stability and integrity, whereas global hypomethylation of LINE-1 ... Voir le document complet
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Circulating tumour cells as a potential biomarker for lung cancer screening: a prospective cohort study
... Charles-Hugo Marquette, Jacques Boutros, Jonathan Benzaquen, Marion Ferreira, Jean Pastre, Christophe Pison, Bernard Padovani, Faiza Bettayeb,. Vincent Fallet, Nicolas Guibert, et al[r] ... Voir le document complet
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HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models
... involved in pertuzumab response in ovarian cancer [10], but it could also influence pancreatic cancer tumorigenesis [11] because it is often overexpressed in pancreatic cancer ... Voir le document complet
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5
... A New Therapeutic Strategy to Combat Residual Inflammatory Risk in Patients with Ischaemic Heart Disease? Highlighted by Arduino ...pathways in driving this residual risk and the need for ... Voir le document complet
15
Acetate metabolism in cancer cells
... into cells by members of the monocarboxylate transporter family [5] where acetyl-CoA synthetases (ACSS) catalyze conversion to ...Mammalian cells express mitochondrial and cytosolic forms of ACSS, and the ... Voir le document complet
3
Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases
... autophagy in neonatal brain injury is controversial, with independent studies showing protective effects in brain injury in rodents following inhibition or induction of autophagy by pharmacological ... Voir le document complet
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