Top PDF New insights on ammonia metabolism in endothelial cells of the blood brain barrier
New insights on ammonia metabolism in endothelial cells of the blood brain barrier
... complication of liver disease. Cytotoxic edema is a serious complication of HE, known to be the result of astrocyte ...swelling. Blood derived pathogenic factors such as ammonia ...
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Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes.
... that endothelial cell-cell junctions undergo maturation in the presence of ...above, the extremely low permeability of the BBB in situ is directly related to ...
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Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier
... analysis of HIV-1 intra-endothelial cell ...to the cell monolayers for 4 h at 37°C. After washings with PBS, cells were fixed for 10 min with 4% paraformaldehyde and then with 1% ...
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Transient and Local Increase in the Permeability of the Blood-Brain Barrier and the Blood-Retinal Barrier by Hyperthermia of Magnetic Nanoparticles in a Rat Model
... consisting of endothelial cells that are tightly ...This barrier markedly protects neurons by controlling the passage of the molecules into the retinal ...By ...
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Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics
... Modelling the BBB In vitro models that can accurately mimic the BBB in culture are crucial tools for the development of brain-permeable drugs at the pre-clinical ...
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Strategies used by bacterial pathogens to cross the blood–brain barrier
... invasion in the CSF, and neuronal ...degrade the extracellular matrix, increasing BBB permeability and allowing cell migration (Sellner & Leib, ...promotes the expression of ...
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Emerging technologies for delivery of biotherapeutics and gene therapy across the blood–brain barrier
... Delivery of Biotherapeutics Across the Blood–Brain Barrier ...depiction of the design and mechanisms of blood–brain barrier (BBB) ...
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Edaravone Protects against Methylglyoxal-Induced Barrier Damage in Human Brain Endothelial Cells
... prevention of methylglyoxal-induced injury is in the focus of current research ...was the first drug extensively studied, and attenuated the development of a range ...
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Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model.
... Background The human brain is protected by the existence of the blood–brain barrier (BBB), which consists of brain capil- lary endothelial ...
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Zika virus crosses an in vitro human blood brain barrier model
... infection of the i-BECs was identi- ied 24 h post-exposure to the virus by immunoluo- rescence ...detected in cell lysates by Western blotting after only a 2-h exposure ...to the ...
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Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood-Brain Barrier.
... 13 of 15 4.7. Statistical Analysis Because the raw expression values from FITC-D assay were right-skewed, they were log-transformed before the ...analysis. The mean values of each ...
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Insights from numerical simulations of brain blood flow regulation in large anatomical networks
... Sylvie Insights from numerical simulations of brain blood flow regulation in large anatomical networks ...(2013) In: International Union of Physiological Sciences - IUPS ...
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Identifying the direct effects of ammonia on the brain
... 2008). In addition to ammonia being capable of crossing cell membranes through diffusion as well as through K + ion channels and transporters, there is increasing evidence that a specific ...
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
... To integrate these features into a physiologically relevant blood-brain barrier model, we designed an in vitro microvascular network platform formed via vasculogenesis[r] ...
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In vivo imaging of blood-brain barrier disruption in a multiple sclerosis animal model
... done in vivo and have a much lower resolution due to the imaging technique used, ...requires the sample to be homogenized in order to measure the level of radiocactivity per gram ...
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Molecular mechanism of ultrasound interaction with a blood brain barrier model
... understand the molecular impacts of HIFU and LIFU on the BBB ...opening. The study shows that even with a relatively high ultrasound inten- sity of 400 bar, the structures ...
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Integration of an in vitro blood brain barrier model with organic electrochemical transistors
... recording of electrogenic cells Electrical stimulation and recording of nerve tissue and neural activity have provided valuable information about physiological and pathological functions of ...
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Endosomal trafficking regulates receptor-mediated transcytosis of antibodies across the blood brain barrier
... ‘tracking’ in endo- somal compartments of brain endothelial ...Rat brain endothelial cells were co-incubated with blood-brain barrier (BBB)-crossing ...
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Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat
... Immunofluorescence Brain sections embedded in OCT and cut on a cryostat (10 μm) were prepared for either occludin or claudin-5, and von Willebrand factor (vWF) double immunofluor- escence, or ...IL-1β. ...
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Blood–brain barrier models in pre-clinical assessment of CNS-targeting cell and gene therapies
... to the central role of the BBB damage and ...els of inlammatory cytokines (IL6, TNFg and TNFb) lead to BEC ac- tivation, a loss of BBB functional integrity and subsequent vasogenic ...
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