[PDF] Top 20 Innate immune cells and their contribution to T-cell-based immunotherapy
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Innate immune cells and their contribution to T-cell-based immunotherapy
... T cell-centered vision, which relies on the capacity of infiltrated T cells in controlling and killing tumor ...T cell activation is not a cell-autonomous process and requires ... Voir le document complet
22
Harnessing γδ T cells in anticancer immunotherapy
... immunogenic cell death in-duced by chemotherapy could influence the composition of the immune infiltrate present in tumors, which in turn could affect the therapeutic ...T cells that produce IL-17 ... Voir le document complet
16
Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia
... B Cells Results in Enhanced Th1 Responses We next sought to determine the bio- logical relevance of endosomal TLR signaling in B cells during ...infection. To this end, we infected mMT-Unc93b1 ... Voir le document complet
12
Attacking tumor cells with a dual ligand for innate immune receptors.
... , and impaired their anti-tumor vaccine ...T cell responses, suggesting that NLR signaling was important for T cell priming ...impaired immune responses demonstrating that lagellin ... Voir le document complet
3
Immunomodulatory properties of human MuStem cells: assessing their impact on adaptive and innate immunity
... approaches based on allogeneic stem cell delivery were shown to be attractive for the treatment of genetic muscular ...for their clinical translation is the immune rejection of donor ... Voir le document complet
2
Diversity of innate immune cell subsets across spatial and temporal scales in an EAE mouse model
... labeled immune cells in Thy1-CFP//LysM-EGFP//CD11c- EYFP ...LysM-EGFP and CD11c-EYFP expression in microglia and the various immune cell types infiltrating the CNS during EAE ... Voir le document complet
17
Chronic circadian disruption modulates breast cancer cell stemness and their immune microenvironment to drive metastasis in mice
... order to identify potential molecular players and pathways that drive the increased number of dissemination in JL mice, we performed a mRNA-seq study on bulk of dissociated primary tumour cells ... Voir le document complet
32
Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response
... stress and the activation of the cell-intrinsic innate immune ...exposure to agents generating replication stress and replication stress-deficient cells engender the ... Voir le document complet
27
β2-adrenergic signals downregulate the innate immune response and reduce host resistance to viral infection
... susceptibility to viral infection. Stimulation of the β2-AR pathway was found to be detrimental for host survival to MCMV infection, suggesting that the stress mediators adrenaline and ... Voir le document complet
17
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.
... Th17- and TLR-mediated responses To further characterize the response to flagellin, we performed a microarray time course analysis of gene expression in the distal ileum of treated ...signaling ... Voir le document complet
15
Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases
... stem cells (HSC) generate normal immune ...dendritic cells (DCs) to iNKT ...iNKT cells produce IL-4 but the possibility of a T-cell receptor (TCR)-independent mechanism for IL-4 ... Voir le document complet
17
Lipoglycans Contribute to Innate Immune Detection of Mycobacteria
... Science and Technology, CSIR, Thiruvananthapuram, India Abstract Innate immune recognition is based on the detection, by pattern recognition receptors (PRRs), of molecular structures that are ... Voir le document complet
10
A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
... in immune cells and in some tumor cells 2 ...leads to Na + and Ca 2+ influx, and, after prolonged activation, to the opening of a larger con- ductance membrane ...is ... Voir le document complet
18
Helper-like Innate Lymphoid Cells in Humans and Mice
... years, and their biological role remained ...appear to be essential for host survival in individuals with an intact adaptive immune system [ 122 ...alterations to adaptive immunity, ... Voir le document complet
18
Combining RAIT and immune-based therapies to overcome resistance in cancer? Combining RAIT and immune-based therapies to overcome resistance in cancer?
... A31 and BCL 1 B-lymphoma models ...monocytes and macrophages, and participates to their ...targeted to CD40 can have multiple complementary anti-tumor ...able to generate ... Voir le document complet
29
A hierarchy of graph-based methods to study the behavior of immune cells in vivo
... gens to the site of T cell activation or acting as APC [1, 65, ...[28], their post-recruitment behavior remains widely ...of cells towards a common target [49, 130, ...influx and swarm ... Voir le document complet
308
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver
... Various immune subsets play a critical role in the regulation of fibrosis progression and regression by controlling hepatic myo- fibroblast accumulation, including innate and adaptive ... Voir le document complet
13
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response
... designed to analyze innate myeloid cells by mass ...markers and their associated biological functions are ...single cells from FCS files were grouped into clusters sharing ... Voir le document complet
19
Immune checkpoints on innate lymphoid cells
... of their additive or synergistic effects on antitumor re- ...2017) and on ILC-2s (Taylor et ...restricted to T lymphocytes (see second figure). Interestingly, human and mouse ILC-2s express ... Voir le document complet
4
Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression
... decreased to the level of untreated mice [62]. Thus, B cells have the capacity to regulate the inflammatory responses in arthritis, in part, by educating T cells within a regulatory ...B ... Voir le document complet
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