[PDF] Top 20 Influence of covariance between random effects in design for nonlinear mixed-effect models with an illustration in pediatric pharmacokinetics.
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Influence of covariance between random effects in design for nonlinear mixed-effect models with an illustration in pediatric pharmacokinetics.
... covariance between random effects for multiple-response population PK and for population PK/pharmacodynamics ...objectives of Ogungbenro et al. were to investigate the ... Voir le document complet
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Some alternatives to asymptotic tests for the analysis of pharmacogenetic data using nonlinear mixed effects models.: Alternatives to Asymptotic Tests in NLMEM: an Application to Pharmacogenetics
... model in a linear fashion, we also consider using a F -distribution for the Wald test, a widely used method in LMEM (Ver- beke and Molenberghs, ...df of the DF PB approach which is derived ... Voir le document complet
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Parameter Estimation in Nonlinear Mixed Effect Models Using saemix, an R Implementation of the SAEM Algorithm
... robustness of the estimated parameters can be assessed by changing the random seed (argument seed) and initial estimates of the parameters around the final ...proposed in ( Lavielle ( 2014 ... Voir le document complet
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Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect
... estimated together relative to the wild type (baseline CL). Then at each successive step the genotype effect with the less significant parameter (with the greatest p value) was removed. Moreover, ... Voir le document complet
19
Detecting mistakes in engineering models: the effects of experimental design
... mistakes in engineering models. The subjects in the fractional factorial condition may prefer to use paired comparisons between two individual experimental outcomes as a heuristic for ... Voir le document complet
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Study of interactions between close HVDC links inserted in an AC grid: A mixed nonlinear and modal analysis approach
... (see, for example, [3]) and stated by international working groups ([4], ...analysis of interactions between the converters of closed-connected HVDCs immersed in the AC grid is ... Voir le document complet
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Methods and software tools for design evaluation in population pharmacokinetics-pharmacodynamics
... reasons for the differences, ...type of ODE solver can be controlled for in the evaluation as all software use MATLAB, except ...developers of MATLAB software to implement exactly the ... Voir le document complet
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Pharmacokinetic similarity of biologics: analysis using nonlinear mixed-effects modeling.
... estimation of parameters through NCA does not require the assumptions inherent in model-based approaches and tends to be more acceptable and familiar to Health ...is an “assumption-free” approach, it ... Voir le document complet
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Latent variables and structural equation models for longitudinal relationships: an illustration in nutritional epidemiology.
... number of tests and limiting multiple testing difficulties. Here, each of the individual measurement analyses gave similar conclusions, which were the same as that obtained with the latent variable ... Voir le document complet
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Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers.
... generation of clopidogrel active metabolite and inhibition of platelet function were reduced less by the coadministration of dexlansoprazole or lansoprazole with clopidogrel than by the ... Voir le document complet
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A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed-effects models.
... bias for estimating the uncertainty of ...both random effects and residuals were resampled remained the best methods and selected as bootstrap candidates for linear ... Voir le document complet
37
Covariance estimation and study of models of deformations between distributions with the Wasserstein distance
... Rennes Président du jury Fabienne COMTE Université Paris Descartes Rapporteur Béatrice LAURENT-BONNEAU Université Paul Sabatier Examinateur Jean-Michel LOUBES Université Paul Sabatier Di[r] ... Voir le document complet
1
Concentration of Measure and Large Random Matrices with an application to Sample Covariance Matrices
... point of view on the notion. That does not mean that the presentation of the theory will be ...always with their proofs, all the important theorems and propositions necessary to appre- hend the ... Voir le document complet
88
Temperature dependence in random matrix models with pairing condensates
... imposition of an antiperiodic boundary condition on the fermion ...degree of freedom in representing temperature terms in a random matrix ...basis for the frequency ... Voir le document complet
9
An activity-based approach for surveying and modelling travel behaviour: analysis of the mixed-mode design effects
... lead an efficient policy, governments require reliable predictions of travel behaviour, traffic performance, and traffic ...transportation models can provide the right framework to support long-term ... Voir le document complet
1
Mixed behavior identification in nonlinear nanomechanical resonators
... shown in Figure 2a has been ...choices. In order to electrically characterize its sensitive part (the resonator described in Figure 2b), the device was placed in a vacuum chamber (down to 1 ... Voir le document complet
3
Stability of a nonlinear oscillator with random damping
... the nonlinear oscillator with random ...system, in which the noise acts on the velocity variable rather than on the po- sition, provides another example of a bifurcation induced by a ... Voir le document complet
10
Relationships between nonlinear and space-variant linear models in hyperspectral image unmixing
... signatures of the materials present in the imaged scene (called endmembers), and to estimate their proportions (called abundances) in each ...contributions of each material are assumed to be ... Voir le document complet
6
Representation in early stage design: an analysis of the influence of sketching and prototyping in design projects
... instead of trying to rank all teams individually, we tried to look for some consensus among clusters of teams, ...majority of reviewers may have thought, for instance, that teams A and ... Voir le document complet
11
Mixed-Integer Nonlinear Programming Optimization Strategies for Batch Plant Design Problems
... set of seven increasing size examples was created in order to consider complexity as a parameter of the ...implemented in the DICOPT++ solver, failed to give any result as soon as the problem ... Voir le document complet
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