[PDF] Top 20 Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
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Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
... with the TdLN, the frequency of host Tregs in non- tumor dLNs was not ...administration of DBY peptide with CpG at a distant site from the tumor but not at ... Voir le document complet
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T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way
... that the number of each ILC subset is increased in the PLNs ( Figure 1 C), whereas type 2 ILCs are specifically induced in the MLNs of T cell-deficient mice ( Figures 1 B ... Voir le document complet
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CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network
... mice, tumor- specific CD8 + T cells were primed in the draining lymph node and infiltrated the tumor but failed to control tumor growth ... Voir le document complet
16
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
... Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression, which can be partly ... Voir le document complet
16
Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
... For in vitro assays, skin-draining LNs (axillary, brachial and inguinal) of wild-type or K14-mOva mice were dissected, digested and sorted for long-term cultures as described before ( Baptista ... Voir le document complet
20
Activation of tolerogenic dendritic cells in the tumor draining lymph CD8+ T cells engineered to express CD40 ligand
... development of CD4 + and CD8 + regulatory T cells and anergy of antigen-specific T cells ...increase the therapeutic efficacy of adoptively transferred T ... Voir le document complet
17
Functional characterization of PD1+TIM3+ tumor-infiltrating T cells in DLBCL and effects of PD1 or TIM3 blockade
... (DLBCL), tumor-infiltrating T lymphocytes (TILs) are involved in therapeutic ...However, tumor-specific TILs can be dysfunctional, with impaired effector ...involved in this exhaustion, and ... Voir le document complet
15
Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
... targeting the FAPα + fibroblasts in pancreatic carcinoma [ 241 ], but not the α SMA + subsets [ 242 ], further strengthening the functional diversity of these distinct CAF ...antibody, ... Voir le document complet
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Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
... targeting the FAPα + fibroblasts in pancreatic carcinoma [ 241 ], but not the α SMA + subsets [ 242 ], further strengthening the functional diversity of these distinct CAF ...antibody, ... Voir le document complet
35
Intracellular Fate of Hydrophobic Nanocrystal Self‐Assemblies in Tumor Cells
... droplet of about 50-100 µL of colloidosome and supraball aqueous suspensions was deposited on a freshly cleaved mica surface prior scanning probe microscopy (SPM) ...measurements. The samples were ... Voir le document complet
28
Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells.
... spleen or total Tregs isolated from secondary lymphoid organs and BM, which exhibit significant difference in CD127 ...expression. In both analyses, CD127hi Tregs exhibited higher phosphorylation ... Voir le document complet
15
Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells
... reach the peripheral blood (Figure 1 ...gradient of CTCs, with the liver as a frequent organ to accommodate distant metastases in CRC (Deneve et ...after tumor resection, CTC numbers ... Voir le document complet
17
Vasculature analysis of patient derived tumor xenografts using species-specific PCR assays: evidence of tumor endothelial cells and atypical VEGFA-VEGFR1/2 signalings.
... expected, the levels of mCd31, mCd105, mVegfr1 and mVegfr2 transcripts were significantly lower in the two bevacizumab-treated NSCLC xenografts as compared to matched non-treated xenografts ... Voir le document complet
14
In vitro induction of lymph node cell proliferation by mouse bone marrow dendritic cells following stimulation with different Echinococcus multilocularis antigens
... no, or only weak, responses to any of the stimulations, raises the question of how far this parasite is triggering a down-regulation of the immune response in its ... Voir le document complet
10
Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anti-cancer therapies
... from the FNRS (FRSM - Télévie) , the J. Maisin Fundation and the Belgian Federation against ...Influence of intermittent hypoxia on the vascular and tumor cell compartments: ... Voir le document complet
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Transient Complement Inhibition Promotes a Tumor-Specific Immune Response through the Implication of Natural Killer Cells
... inhibition of complement increased NK cell numbers in spleen and tumor leading to the.. 68.[r] ... Voir le document complet
24
CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes.
... observed in healthy subjects (Online resource, Supple- mentary Figure 3, panels A, B and ...C). In order to verify whether CD8? CD28-CD127 lo CD39?Treg were present and functional at the tumor ... Voir le document complet
12
CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells
... CD40L. The expression of HLA-DO, a molecule described previously to alter the MHC class II/peptide repertoire and to inhibit the presentation of nonspecific exogenous soluble antigens, ... Voir le document complet
8
Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity
... Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity Rita Vicente, Julie Quentin, Anne-Laure ... Voir le document complet
41
Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth
... [Abstract] In 1999, Hahnfeldt et al. [1] proposed a mathematical model for tumor growth as dictated by reciprocal communications between tumor and its associated vasculature, introducing the ... Voir le document complet
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