[PDF] Top 20 Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout
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Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout
... INTRODUCTION Liver regeneration triggered by partial hepatectomy has been extensively studied in rodent models, to dissect the mechanisms that control hepatocyte ...the liver, ... Voir le document complet
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LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration
... Accelerates Hepatocyte Proliferation during Regeneration in Mouse Liver We investigated the contribution of LKB1 to hepatocyte prolifer- ation during liver ... Voir le document complet
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Platelet interactions with liver sinusoidal endothelial cells and hepatic stellate cells lead to hepatocyte proliferation
... interact with LSECs in liver sinusoids following partial hepatectomy in ...associated with a method for in vivo endogenous platelet labeling, we observed increased adherence of ... Voir le document complet
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Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver
... conducted in accordance with internal guidelines of the French Ministère de l'Agriculture for animal ...handling. Mice heterozygous for targeted disruption of the Cbs gene (Cbs +/-) [23] were ... Voir le document complet
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Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.
... and in vivo infection ...Anaesthetised mice were injected intra- venously into the retro-orbital sinus vein with ...twice with RPMI and resuspended in human AB plasma at 50% ... Voir le document complet
10
TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
... of regeneration, acute and chronic liver disease presented here, we were able to confirm knowledge of the expression patterns of TGF-β1 in liver ...TGF-β2 in CLD and HCC is less ... Voir le document complet
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en fr Transplantation of genetically modified hepatocytes : liver regeneration and approaches for improving hepatocyte engraftment Transplantation d'hépatocytes génétiquement modifiés : régénération hépatique et moyens d'amélioration de la prise de greffe hépatocytaire
... Transplantation in Rodents Many studies have shown that hepatocytes (approxi- mately 20–40 !m diameter) transplanted in rodents via the spleen or the portal vasculature enter through portal vein branches ... Voir le document complet
193
Hypothermia in acute liver failure
... recently in rats with ALF using nuclear magnetic resonance (NMR) spectroscopy (Chatauret et ...dehydrogenase in the tricarboxylic acid cycle (Lai and Cooper, 1986)) and maintain ATP ...demonstrated ... Voir le document complet
9
Liver X Receptors Protect from Development of Prostatic Intra-Epithelial Neoplasia in Mice
... Mutant Mice Fed a High-Cholesterol Diet Our data showed that control of cholesterol homeostasis by LXR is crucial to restrain epithelial cell proliferation in the ...prostate. In order ... Voir le document complet
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Alcoholic liver disease: when to consider liver transplantation?
... offer liver transplantation to the patients with ALD who are most capable of maintaining sobriety, alcohol relapse after transplantation is not ...after liver transplantation are highly vari- ... Voir le document complet
16
Hypervascular nodule in a fibrotic liver overloaded with iron: identification of a premalignant area with preserved liver architecture.
... 4b), with less iron (Fig. 5b), less glycogen (Fig. 6a), and with foci of clear hepatocytes ...6b). In these clear areas, hepatocytes were slightly bigger and occasionally displayed in two ... Voir le document complet
12
Transplantation of hESC-derived hepatocytes protects mice from liver injury
... Background Hepatocyte transplantation has been proposed as an alternative to orthotopic liver transplantation for treat- ment of patients with acute liver failure (ALF) and metabolic ...the ... Voir le document complet
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Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice
... male mice (n = 62 and n = 96) were fed an HFD for 3 months to provide a model of metabolic ...C57BL/6 mice, either WT or of dif- ferent genotypes, with diverse gut microbiota (ob/ob, Nod1, Cd14 ... Voir le document complet
12
Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.
... blocked with Avidin/Biotin Blocking Kit (Vector Laboratories) then 20% swine serum in ...incubated with primary antibodies anti-Ki67 (Novacastra, rabbit, 1:1000), AFP (Dako, rabbit, 1:75), Gli2 ... Voir le document complet
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Elevated serum liver-type fatty acid binding protein levels in non-acetaminophen acute liver failure patients with organ dysfunction.
... of liver injury in patients with DILI in the absence of ALF ...FABP1 in 198 acetaminophen (APAP)-ALF patients ...associated with increased mortality and improved prognostic ... Voir le document complet
13
Liver transplantation for irresectable colorectal liver metastases: still a contraindication?
... limitation is the scarcity of the liver grafts. This is the major ethical barrier for this kind of ...criteria liver donors. In this context a new surgical technique has been recently ... Voir le document complet
5
Donation after Cardiac Death In Liver Transplantation :is donor age an issue?
... Results : Liver fibrosis was associated with patient’s age, inflammatory activity, 8 biochemical indicators and all four protein markers. A 7-marker panel (Fibro7-score) based on a-2-macroglobulin, ... Voir le document complet
1
The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.: PPARalpha controls the expression of the sIL-1ra in liver
... which is generally protective and aimed at promoting tissue ...response is mediated by a diverse group of cytokines and other signaling molecules that are able to profoundly influence cellular ...conspire ... Voir le document complet
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Increased brain lactate is central to the development of brain edema in rats with chronic liver disease
... role in cell volume ...[44]. In hyperammonemic portacaval shunted rats, it is stated that the reason brain edema does not develop, even in the presence of increased brain glutamine, is ... Voir le document complet
13
Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure
... ailing liver is a major source of ROS [49]. Because an increase in XO activity was found in BDL rats, allopurinol, a XO inhibitor, was investigated as an antioxidant (oxidant inhibitor) ... Voir le document complet
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