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[PDF] Top 20 Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies.

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Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies.

Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies.

... archive for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...teaching and research institutions in France or abroad, or from public or private ... Voir le document complet

41

Hepatitis C virus entry: molecular mechanisms and targets for antiviral therapy.

Hepatitis C virus entry: molecular mechanisms and targets for antiviral therapy.

... attachment and entry is a major target of adaptive host cell ...system and induce the production of ...exhibit antiviral activity in vitro and are defined as virus-neutralizing ... Voir le document complet

17

Ultradeep Pyrosequencing and Molecular Modeling Identify Key Structural Features of Hepatitis B Virus RNase H, a Putative Target for Antiviral Intervention.

Ultradeep Pyrosequencing and Molecular Modeling Identify Key Structural Features of Hepatitis B Virus RNase H, a Putative Target for Antiviral Intervention.

... against hepatitis B virus (HBV) and have a high barrier to resis- ...possible, and cure of infection cannot be achieved with these therapies, emphasizing the need for alternative ... Voir le document complet

11

Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses

Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses

... fever virus (YFV) vaccine 17D stands as a “gold standard” for a successful ...mouse and chicken embryo tissues. Despite its immense success, the molecular determinants for virulence ... Voir le document complet

16

Host–virus interactions during hepatitis C virus infection : a complex and dynamic molecular biosystem

Host–virus interactions during hepatitis C virus infection : a complex and dynamic molecular biosystem

... cirrhosis and hepatocellular carcinoma (HCC) ...diagnostic and prognostic markers, and the absence of broadly effective treatment ...response, and ribavirin, an antiviral nucleoside ... Voir le document complet

13

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes.

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes.

... Chronic hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are the leading causes of liver dis- ease and cancer ...rier and sodium taurocholate co-transporter NTCP has ... Voir le document complet

19

Cholesterol uptake and hepatitis C virus entry.

Cholesterol uptake and hepatitis C virus entry.

... alpha and ribavirin has markedly improved the treatment outcome, viral resistance and adverse effects still remain important ...HCV entry is the first step of virus- hepatocyte interaction ... Voir le document complet

9

Hepatitis C virus entry.

Hepatitis C virus entry.

... of hepatitis C virus entry for pathogenesis of liver disease and antiviral therapy ...Conclusions and perspectives 1. Discovery and characterization of ... Voir le document complet

42

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

... cells and (e) HCVpp entry into PHH after inhibition of binding and postbinding steps by the indicated compounds (EGFR-specific mAbs: 10 and 50 µg mL –1 ) (f,g) Effect of Erlotinib ... Voir le document complet

32

Genotype 1 hepatitis C virus envelope features that determine antiviral response assessed through optimal covariance networks

Genotype 1 hepatitis C virus envelope features that determine antiviral response assessed through optimal covariance networks

... 1a and 1b viruses evolve are provided by the collection of the 50 aa pairs with the highest covariance (Figure ...SVR and NR individuals were scattered within these subgroups (Figure ...groups. For ... Voir le document complet

10

CD81-receptor associations-impact for hepatitis C virus entry and antiviral therapies

CD81-receptor associations-impact for hepatitis C virus entry and antiviral therapies

... Conclusions and Perspectives TEMs play a role in membrane compartmentalization leading to coupling and/or regulating molecular machinery and signaling pathways in a tissue specific ...HCV ... Voir le document complet

19

Hepatitis E Virus

Hepatitis E Virus

... important for establishing cell culture ...initial virus propagation, and thus the production of robust HEV culture systems ...strain, and HEV3-Kernow C1/P6 [31], derived from a chronically ... Voir le document complet

14

Effet antiviral des interférons sur le virus BK

Effet antiviral des interférons sur le virus BK

... D’autres études ont souligné un rôle de IDO dans la persistance et/ou la progression de certaines infections virales en raison de ses propriétés immunomodulatrices [118]. En participant à la tolérance immunitaire ... Voir le document complet

74

Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.

Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.

... of Hepatitis C Virus Cell Entry Factors Mediate Escape from Neutralizing Antibodies Article Type: Basic - Liver/Pancreas/Biliary Section/Category: Human Research - Human Material Corresponding ... Voir le document complet

59

Role of DC-SIGN in Lassa Virus Entry into Human Dendritic Cells

Role of DC-SIGN in Lassa Virus Entry into Human Dendritic Cells

... isolates and that productive infection causes virus-induced perturbation of their antigen-presenting function ( 5 , 6 ...try into human DCs, we therefore used primary human MDDC as a ...live ... Voir le document complet

12

Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps

Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps

... multifunctional entry factor essential for infectivity of HCV particles with different biophysical proper- ties and host protein ...differential entry steps and receptor usage. ... Voir le document complet

27

Molecular scale insights into interaction mechanisms between organic inhibitor film and copper

Molecular scale insights into interaction mechanisms between organic inhibitor film and copper

... interaction mechanisms of 2-MBI with copper surfaces are still discussed, and deeper insight from experimental studies at the molecular scale is ...molecule and the substrate, whether the ... Voir le document complet

9

Direct-acting Antiviral Therapy Restores Immune Tolerance to Patients With Hepatitis C Virus-induced Cryoglobulinemia Vasculitis

Direct-acting Antiviral Therapy Restores Immune Tolerance to Patients With Hepatitis C Virus-induced Cryoglobulinemia Vasculitis

... BR3 and PD-L1 expressions on B cells increased after DAA ...concentration and decrease in BR3 staining, a factor which may indicate an increase in BAFF receptor-ligand activity 19 ... Voir le document complet

29

Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients.

Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients.

... Karine Lacombe, Joël Gozlan, Anders Boyd, Pierre-Yves Boelle, Philippe Bonnard, Jean-Michel Molina, Patrick Miailhes, Caroline Lascoux-Combe,. Lawrence Serfaty, Fabien Zoulim, et al[r] ... Voir le document complet

2

Hepatitis C virus-related vasculitis

Hepatitis C virus-related vasculitis

... patients and mononeuritis multiplex in one-third of ...common and usually set in ...palsies, and seldom cerebrovascular ...failure and is among the causes of death of patients with ...pain ... Voir le document complet

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