[PDF] Top 20 A guide to assessing Endoplasmic Reticulum homeostasis and stress in mammalian systems
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A guide to assessing Endoplasmic Reticulum homeostasis and stress in mammalian systems
... The endoplasmic reticulum (ER) represents a complex membranous network that beyond ensuring cell calcium and lipid homeostasis, mediates the productive folding and trafficking of ... Voir le document complet
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Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease
... threats to public health systems because of the increasing incidence of its related ...changes in developed countries have led to caloric excess, lack of physical activity and increased ... Voir le document complet
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Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors
... The endoplasmic reticulum (ER) is the gateway to the secretory pathway thus maintaining the communication between the cell’s intracellular space and extracellular ...environment. In ... Voir le document complet
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en fr Mild Endoplasmic Reticulum Stress Protects From Cell Death : The Role Of Autophagy Un stress modéré du réticulum endoplasmique protège de la mort cellulaire : rôle de l’autophagie
... altered to expose a new epitope during apoptosis ...next to mitochondria ...(Dark), a component of the apoptosome, carries a WD repeat domain, which is a potent interaction ... Voir le document complet
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en fr Role of the sirtuine 1 in the modulation of endoplasmic reticulum stress response and apoptosis in cardiomyocytes Rôle de la sirtuine 1 dans la modulation de la réponse des cardiomyocytes au stress RE et à l’apoptose
... études in vivo du rôle de SIRT1 dans le cœur ont été confrontées au problème lié à l’invalidation de SIRT1 qui induit de fortes perturbations développementales conduisant à la mort des nouveaux nés (Cheng, ... Voir le document complet
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Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores.
... microscopy and colocalization LNCaP cells were grown on cover slips and treated with puromycin as described ...minutes and blocked with 1.2% gelatine in PBS (PBSG) for 30 minutes to ... Voir le document complet
9
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion
... is a fundamental process that enables the coordinated movement of groups of cells that remain connected via cell-cell junctions (Figure 2 , (1)) [ 29 ...]. In this migration mode, cells remain physically ... Voir le document complet
26
Endoplasmic reticulum and lysosomal quality control of four nonsense mutants of iduronate 2-sulfatase linked to Hunter’s syndrome
... macromolecules in the lumen of lysosomes (Marques and Saftig, ...is a rare X-linked recessive LSD characterized by mutations of the gene encoding for iduronate 2-sulfatase (IDS) (Bach et ...leads ... Voir le document complet
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Altered interplay between endoplasmic reticulum and mitochondria in Charcot–Marie–Tooth type 2A neuropathy
... Interestingly, a fraction of MFN2 is also located at the endo- plasmic reticulum (ER) membrane, in particular at specialized Significance Interactions between mitochondria and the ... Voir le document complet
14
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
... localization To explore the functional relevance of AGR2 dimerization, we tested how AGR2 regulates cargo ...CD59 and LYPD3, that were reported in proteo- mics studies, were confirmed using ERMIT ... Voir le document complet
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Toll-like receptor 4 knockout mice are protected against endoplasmic reticulum stress induced by a high-fat diet.
... Activation in Adipose Tissue TLR4 appears to mediate the signal linking obesity to insulin ...unclear and seem to be organ-dependent [66]. In the present study, we found that ... Voir le document complet
11
BAT3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum
... folding in the endoplasmic reticulum (ER) is an inherently fallible ...cycle and are often targeted for dislocation to the cytosol, followed by ubiquitin-dependent degradation by the ... Voir le document complet
9
Comparison of proteins of the endoplasmic reticulum from control rat liver with proteins of the endoplasmic reticulum from dissected liver tumor nodules
... L’auteur a autorisé l’Université de Montréal à reproduire et diffuser, en totalité ou en partie, par quelque moyen que ce soit et sur quelque support que ce soit, et exclusivement à des fins non lucratives ... Voir le document complet
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Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance.: Palmitate induces ER stress in myotubes
... ER stress in skeletal muscle We fed male C57Bl/6 mice with a standard diet (SD, 3% lipids) or a diet enriched in 20% of palm oil (HPD), in order to measure the ... Voir le document complet
26
Droplet-based microfluidic systems to incorporate nucleic acids into cationic liposomes and to transfect mammalian cells in vitro
... used in immunotherapeutic approaches, particularly in immunotherapies against ...used to load DCs with antigens, ...out in this function as gene carriers, since besides to transfect ... Voir le document complet
140
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites
... reprogramming and oncogenesis. Our findings show that autophagy occurring at a specific subcellular location, namely the interconnection between mitochondria and the ER, supplies FFAs to ... Voir le document complet
15
The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria.
... restores a cytosolic Ca 2+ signal, it cannot evoke Ca 2+ passage from ER stores to the mitochondrial ...fails to restore the ‘wild-type’ cytosolic Ca 2+ signal, indicating that mitochon- drion- ... Voir le document complet
15
A Hitchhiker's Guide to Model-Driven Engineering for Data-Centric Systems
... decision, and change) represents decision support activities ...analysis) and the ap- plication of consequent changes to the prescriptive ...or in an automated fashion ...enacting a ... Voir le document complet
10
A Brief Yet Practical Guide to Reforming U.S. Voter Registration Systems
... one-third and the goal would be to reduce the ‘‘Not Deadwood’’ portion of the Inactive list below ...data and list-matching technologies can be used to develop indicators of and targets ... Voir le document complet
7
GABAB receptor cell surface export is controlled by an endoplasmic reticulum gatekeeper
... both a significant increase of their overall locomotor activity ( Figure 5d,e ) and a contralateral turning phenotype ( Figure 5f, Movie S1a ) compared to control AAV-GFP-injected mice (Movie ... Voir le document complet
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