Haut PDF Glucolipotoxicity and the control of pancreatic ℓ-cell apoptosis
Glucolipotoxicity and the control of pancreatic ℓ-cell apoptosis
... figure 24: The fatty acid 8-oxidation inhibitor etomoxir induces palmitate toxicity at Iow glucose and enhances palmitate toxicity at high glucose 56 Figure 25: Elevated glucose plus sat[r] ...
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TGFBI, an ECM interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration
... migration and invasion of pancreatic cancer cells through alteration of cell-ECM ...analysis of PANC-1 and HPAF-II protein extracts 24–72 hr after TGFBI ...loading ...
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A model of apoptosis receptor reactions to study cell fate decision
... HeLa cell, was augmented in the same established ...in the introduction section, a difference in the strength of the apoptotic signal should translate into a variation of ...
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Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma.
... Inhibition of LYN activity is associated with an increase of apoptosis in MCL cells The BCR signal is initially transmitted by LYN kinase leading to activation of various signaling ...
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Therapeutic antibodies for the treatment of pancreatic cancer.: Mabs against pancreatic cancer
... against Pancreatic cancer 9 Mesothelin is a differentiation antigen whose expression in normal human tissues is limited to mesothelial cells lining the pleura, pericardium and peritoneum ...(41). ...
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Xenotropic retrovirus Bxv1 in human pancreatic β cell lines
... as the avian TVA ...later, the conditioned medium from 293T-TVA-Hy* cells was in turn added to naive 293T cells (Figure ...for the Bxv1 genome and transcripts (Figure 3B and ...
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β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice
... under the HFD, while both variables remained unchanged in Arrb2 / islets ...ARRB1 and ARRB2 play key roles in various receptor functions by acting as either GPCR desensitisers or signal transducers ...
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Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin
... indicated the presence of sortilin in 𝛽-cell lines and in mouse islets and of TREK-1 in 𝛽-TC3 cells [23, ...immunocytochemical and immunohistological approaches, that ...
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Modeling Dynamics of Cell-to-Cell Variability in TRAIL-Induced Apoptosis Explains Fractional Killing and Predicts Reversible Resistance
... Questioning the role of survival pathways Several studies reported that TRAIL can induce survival pathways ...transduction and eventually stop apoptotic signaling remains unclear. On the other ...
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Would D'Arcy Thompson have predicted a topological control of apoptosis?
... topological control of apoptosis? The laws that drive morphogenesis remain a major biological ...physical and mechanical constraints proposed by d’Arcy Thompson earlier ...sets ...
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NPS - 2143 (hydrochloride) inhibits melanoma cancer cell proliferation and induces autophagy and apoptosis
... cause of melanoma is ultraviolet light (UV) exposure, pos- sibly from the sun or other sources, such as tanning devices [4, 8] ...factor, and the same risk factors include family history, ...
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Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo
... 33-38 The same biphasic effect of progestins on proliferation of normal mammary epithelial cells has been evoked as an explanation for the higher risk of breast cancer in hormone ...
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The role of transforming growth factor-beta 1 in steroidogenesis, cell proliferation, and apoptosis in cultured bovine granulosa cells
... author and co-authors if applicable retain copyright ownership and moral rights in this ...Neither the whole thesis or dissertation, nor substantial extracts from it, may be printed or otherwise ...
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Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization.
... parental and Src- transformed cells using immunoblotting data of Figure ...amount of proteins in the cytosol fraction compared to the mitochondria compartment which allowed us to ...
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The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner
... Abstract The TP53 gene plays essential roles in ...development and metastasis formation, while mutant p53 has transforming ...factor of cancer progression. The recent discovery of p53 ...
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Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function
... in Pancreatic Beta Cells. KLF11 is expressed in human pancreatic islets and in the pancreatic beta cell lines HIT-T15, INS832 兾13, TC3, and Min6 ...1A and data not ...
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Specificities of β1 integrin signaling in the control of cell adhesion and adhesive strength.
... domain of 1 that controls Rho activity. The role of individual Rho GTPases in fibronectin matrix remodelling has been examined by selectively down regulating their expression in cultured endothelial ...
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Varicella-zoster virus induces apoptosis in cell culture
... http://vir.sgmjournals.org, and is freely available without a subscription.] Abstract Apoptosis is an active mechanism of cell death which can be initiated in response to various stimuli ...
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Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis
... model of sn38 escape was used to determine whether Akt was implicated in the emergence of PLD ...25% of dividing PLD express the Ser473 phosphorylated form of ...contrast ...
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Expression of POU2F3 Transcription Factor Control Inflammation, Immunological Recruitment and Metastasis of Pancreatic Cancer in Mice
... level of DCLK1 protein which serves as a marker [ 22 ...inflammation and immune cells recruitment in some tissues [ 23 ]. Development of TUFT cells is dependent of the expression ...
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