Haut PDF Genomic variation in recombination patterns : implications for disease and cancer
Genomic variation in recombination patterns : implications for disease and cancer
... have implications for understanding aneuploid ...aneuploidies and rearrangements are at an increased risk for various malignancies (Ganmore et ...2009). For example, children with Down ...
278
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer
... monotherapy for the treatment of adult patients with mCRPC and BRCA1 or BRCA2 mutations (germline and/or somatic) whose disease progressed fol- lowing prior therapy that included a ...
15
Disease management patterns for postmenopausal women in Europe with hormone-receptor-positive, human epidermal growth factor receptor-2 negative advanced breast cancer.
... guidelines for advanced BC, country- specific differences in access and use of various agents can influence the treatment regimen that a patient will receive 4 .... For example, in ...
10
Genomic architecture of sickle cell disease clinical variation in children from West Africa : a case-control study design
... signals for which the statistical evidence is strongest; whereas, some susceptibility loci with modest effect sizes might also benefit from further exploration in the context of their biological ...samples ...
290
Cancer stem cells modulate patterns and processes of evolution in cancers
... In the CE model, all the cancer cells can, in principle, ...distinguished in cancers: passenger mutations, ...cells, and driver mutations, ...passenger in one context and ...
26
Extreme Recombination Frequencies Shape Genome Variation and Evolution in the Honeybee, Apis mellifera
... Meiotic recombination is a fundamental cellular process, with important consequences for evolution and genome ...how recombination rates vary across the genomes of most species and the ...
28
Survivin contributes to DNA repair by homologous recombination in breast cancer cells
... Breast cancer Homologous recombination Introduction In the last decade, Survivin has attracted considerable attention as a therapeutic target for anticancer strategies because of its dual ...
11
Does interference between replication and transcription contribute to genomic instability in cancer cells?
... breakage and unscheduled recombination. Studies in model systems such as budding yeast have shown that transcription represents a prominent source of replication fork arrest and genomic ...
15
Patterns of cross-contamination in a multispecies population genomic project: detection, quantification, impact, and solutions
... located in building 32 of University Mont- pellier, ...selves in the field or shipped by colleagues in RNAlater® (Qiagen, Dusseldorf, Germany) ...extraction and cox1 ...quality and ...
17
Identifying common prognostic factors in genomic cancer studies: a novel index for censored outcomes.
... The term is a weighted average of the score calcu- lated at times t l prior to time t j (t l <t j ). The sum of the so- called "robust" W j , j = 1, 傼, N is identical to the sum of the U j , but, as shown by ...
20
Recombination suppression and evolutionary strata around mating-type loci in fungi: documenting patterns and understanding evolutionary and mechanistic causes
... locus* in the button mushroom Agaricus bisporus (Xu et ...automixis* and has very extensively suppressed recombination (Sonnenberg et ...heterothallic and exhibits a quite homogenous ...
23
Developmental origins of non-communicable disease: Implications for research and public health.
... chemicals, and other exogen- ous stresses. Some exposures are largely novel (in evolu- tionary terms) and anthropogenic, and so their effects, and the physiological responses to them, ...
10
Estrogen regulation of epithelial ion transport: Implications in health and disease
... target for steroid hormones and their effects on lung function, inflammation or immune responses to allergen exposure have been studied in ...response in the lung. Cystic fibrosis mice when ...
7
Chronic kidney disease and cancer: a troubling connection.: CKD and cancer
... archive for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...teaching and research institutions in France or abroad, or from public or ...
3
Newborn screening for sickle-cell disease : socio-ethical implications
... period. In this chapter we will focus on neonatal ...cell disease can be treated through early detection and supportive therapies, neonatal screening for sickle cell disease is ...
16
Wolbachia and recombination
... Wolbachia and recombination The endocellular bacterium Wolbachia manipulates its hosts’ reproduction in an impressive variety of ways: it can induce male killing, feminization, thelytokous ...
2
Variation of CD4 Count and Percentage during Pregnancy and after Delivery: Implications for HAART Initiation in Resource-Limited Settings.
... pregnancy and early post- partum period in HIV-infected ...observed in our cohort with the absolute CD4 count increased significantly after delivery in women who had been under ZDV prophylaxis ...
15
Cerebellar influence on motor cortex plasticity: behavioral implications for Parkinson's disease
... controls and co-ordinates complex movements and is important for adapting movements to changes in ...sensory and motor information from descending cortical pathways and ascending ...
9
RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination
... Results and discussion ...required for repair of DSBs by HR Upon the discovery of the murine and human RAD51D, it was noted that several splicing isoforms exist [ 29 ...variants in both mice ...
10
Reinterpreting Patterns of Variation in Human Thyroid Function: An Evolutionary Perspective
... differences in gestational and childhood environments alter the hypothalamic-pituitary-gonadal axis regulation and associated metabolic processes, as immunologically, nutritionally, or otherwise ...
57
