# Haut PDF Extension of the SAEM algorithm for nonlinear mixed models with 2 levels of random effects.

### Extension of the SAEM algorithm for nonlinear mixed models with 2 levels of random effects.

**The**main original element

**of**this study is

**the**development

**of**

**the**

**SAEM**

**algorithm**

**for**two-

**levels**non-linear

**mixed**

**effects**...extend ...

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### Modelisation and estimation of heterogeneous variances in nonlinear mixed models

**Nonlinear**

**mixed**

**effects**

**models**(NLMM) are more and more frequently used

**for**anal- ysis

**of**longitudinal data and repeated measurements in pharmacokinetics, growth and ...

187

### Evaluation of bootstrap methods for estimating uncertainty of parameters in nonlinear mixed-effects models: a simulation study in population pharmacokinetics

**the**inverse

**of**

**the**M F .

**The**bootstrap is an alternative method to assess

**the**uncertainty

**of**parameters without making strong distributional ...(1979)

**for**...

29

### Parameter Estimation in Nonlinear Mixed Effect Models Using saemix, an R Implementation of the SAEM Algorithm

**of**one

**of**these recent estimation algorithms,

**SAEM**, in R, to obtain maximum likelihood ...implemented

**for**instance in nlme and lme4.

**The**different packages all have their ...

43

### Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model.

**of**

**the**observed RSE when M F is computed by

**the**Louis’s principle [30] compared to

**the**RSE observed

**with**

**the**linearization ...Although

**the**approach using ...

30

### Some alternatives to asymptotic tests for the analysis of pharmacogenetic data using nonlinear mixed effects models.: Alternatives to Asymptotic Tests in NLMEM: an Application to Pharmacogenetics

**Nonlinear**

**mixed**

**effects**

**models**allow investigating individual differences in drug con- centration profiles (pharmacokinetics) and ...on

**the**genetic component

**of**this ...

28

### Extension of NPDE for evaluation of nonlinear mixed effect models in presence of data below the quantification limit with applications to HIV dynamic model.

**of**some problems

**of**

**the**Fisher tests, type I errors

**for**

**the**npde computed by

**the**new method, especially those

**of**

**the**global test, are very close to 5% and ...

32

### Extension of the SAEM algorithm to left-censored data in nonlinear mixed-effects model: Application to HIV dynamics model

**the**model and

**the**notations (Section

**2**), Section 3 de- scribes

**the**extended

**SAEM**...reports

**the**simulation study and its results. We simulate datasets using

**the**...

25

### Performance in population models for count data, part II: a new SAEM algorithm.

**the**estimation procedure

**with**

**the**

**SAEM**

**algorithm**in a non-linear

**mixed**effect modelling framework

**for**count data

**models**, showed satisfactory performance ...

32

### Sensitivity analysis with dependent random variables : Estimation of the Shapley effects for unknown input distribution and linear Gaussian models

**Random**Forest, from

**the**R package randomForest, which optimizes auto- matically

**the**parameters by ...estimate

**the**value

**of**Var(E(Y |X))/Var(Y ) to ...denotes

**the**output ...

299

### A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed-effects models.

**of**variance components in many situations [

**2**, 3] .

**The**standard errors (SE)

**of**parameter estimates are obtained asymptotically from

**the**in- verse

**of**

**the**Fisher ...

37

### On the Wave Turbulence Theory for the Nonlinear Schrödinger Equation with Random Potentials

**the**original equation were done in [ 5 , 6 , 10 ], in which they get

**the**1/3 growth, pointing to

**the**six-wave equation discussed in our ...Moreover,

**with**extra dephasing,

**the**growth ...

13

### Mixed-radix Algorithm for the Computation of Forward and Inverse MDCT.

**of**

**the**most computational intensive operations in MPEG audio coding ...new

**mixed**-radix

**algorithm**

**for**efficient computing

**the**MDCT/IMDCT is ...presented.

**The**proposed ...

13

### Virtual Extension of Meta-models with Facet Tools

**for**short), a composition that preserves

**the**compo- nents, is called

**the**"model-based correspondence" by Clavreul who identified 88 techniques

**for**different purposes in his ...

9

### Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models

**the**left-censored data in NLMEM as an exact Maximum Likelihood estimation ...calculate

**the**empirical SE, defined as

**the**sample estimate

**of**

**the**standard deviation from ...

27

### Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm.

**For**

**the**Wald test, we relate this inflation to

**the**under-estimation

**of**

**the**SE

**of**

**the**gene effect ...performed

**the**Wald test using

**the**empirical SE rather ...

16

### Extension of Partitional Clustering Methods for Handling Mixed Data

**the**literature. Most

**of**these methods are based on

**the**use

**of**a distance measure defined either on numerical attributes or on categorical at- ...composed

**of**numerical and categorical ...

10

### BIC selection procedures in mixed effects models

21

### Extension of Random Matrix Theory to the L-moments for Robust Portfolio Allocation

**the**one factor model and show that except

**the**market factor, others risk factors exist and should be took into account (see Black, Jensen and Scholes, 1972), this is at

**the**origin

**of**...

42

### Fixed versus Random Effects in Poisson Regression Models for Claim Counts

**the**estimate

**of**β F E is consistent

**for**fixed T and N → ∞, as

**for**insurance ...Application

**of**

**the**fixed

**effects**Poisson model to

**the**Belgian motor portfolio ...

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