[PDF] Top 20 Expression of pSTAT5 predicts FLT3 internal tandem duplications in acute myeloid leukemia
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Expression of pSTAT5 predicts FLT3 internal tandem duplications in acute myeloid leukemia
... cohort of 75 patients with AML on first diagnosis was included in this ...presence of FLT3-ITD, were considered if paraffin blocks of bone marrow trephine biopsies were available and ... Voir le document complet
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Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients.
... INTRODUCTION Acute myeloid leukemia (AML) is a cytogenetically and molecularly heterogeneous disease characterized by accumulation of a variety of somatically acquired genetic ... Voir le document complet
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STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia
... and Internal Tandem Duplications (ITD) occuring on the juxtamembrane domain (FLT3-ITD) have been described, both leading to constitutive activation of the ...receptor. FLT3-ITD ... Voir le document complet
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Transplant Outcomes for Secondary Acute Myeloid Leukemia: Acute Leukemia Working Party of the European Society for Blood and Bone Marrow Transplantation Study.
... biology of these ...important in future studies because these may be more biologically distinct that previously ...patients in this cohort who had chronic myelomonocytic leu- kemia or other MPNs may ... Voir le document complet
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Large tandem duplications affect gene expression, 3D organization, and plant–pathogen response
... University of Zurich, CH-8008 Zurich, Switzerland; 4 Mendel Centre for Plant Genomics and Proteomics, CEITEC, Masaryk University, 625 00 Brno, Czech Republic; 5 ENS, IBENS, CNRS/INSERM, PSL Research University, ... Voir le document complet
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H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations
... status in clinical development. Modified from [23]. 1.1.8 Inhibition of PRC2 Activity through H3K27 Mutation Recently, lysine-to-methionine (KM) mutations affecting H3K27 have been reported in ... Voir le document complet
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The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
... 10% of GFP- positive ...half of the volume of each quadruplicate was pelleted and frozen down to constitute the day 0 time point, and cells were maintained in culture and split every two days ... Voir le document complet
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en fr Autophagy, a potential therapeutic target in acute myeloid leukaemias expressing FLT3-ITD Autophagie, une cible thérapeutique potentielle dans les leucémies aiguës myéloïdes exprimant FLT3-ITD
... Zinc finger protein 428 Zinc finger protein 30;Zinc finger protein 461;Zinc finger protein 30 homolog;Zinc finger protein 82 homolog;Zinc finger protein 14 homolog.. Zinc finger protein [r] ... Voir le document complet
227
en fr Targeting NPM1c in Acute Myeloid leukemia NPM1C, une cible dans le traitement des leucémies aigues myéloides
... survival of chemotherapy-treated Nucleophosmin-1 mutated Acute Myeloid Leukemia patients (NPM1-mutant ...promyelocytic leukemia protein (PML) tumor suppressor organizes domains that ... Voir le document complet
241
Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
... viability of mutant IDH1 AML cells through apoptotic cell death in ...differentiation of 11 primary patient samples carrying mutant IDH1– R132H (R132) compared with 10 WT IDH1 (WT) and 1 PML-RAR α ... Voir le document complet
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Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy
... Resistance of acute myeloid leukemia (AML) to therapeutic agents is ...addressed. In this paper, we demonstrate that inhibition of deubiquitinylase USP7 signi ficantly reduces ... Voir le document complet
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Analysis of the proteasome-autophagy crosstalk under proteotoxic stress conditions in acute myeloid leukemia
... detection of selective autophagy events Cell culture conditions are crucial to detect molecular events regulated by autophagy since this process is inhibited when cells are grown under rich nutrient conditions and ... Voir le document complet
222
Late cardiomyopathy in childhood acute myeloid leukemia survivors: a study from the LEA program
... Impairment in several domains of QoL has been described in childhood cancer survivors, but to the best of our knowledge, our study is the first to focus on the impact of late cardiac ... Voir le document complet
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Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients
... end of IC, after aplasia completion (ANC > ...irrespective of platelet level, nevertheless platelet transfusion to increase platelet count before AFMT procedure was allowed based on the physician ... Voir le document complet
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Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia
... 4 of 18 A better understanding of this reprogramming process could give a precious insight into the biology of AML and the consequences of IDH1 ...Changes in Fatty Acid Reorganization ... Voir le document complet
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Understanding the transcriptional control of EIF4E and its dysregulation in acute myeloid leukemia: role of NF-κB
... Résumé EIF4E, le facteur d’initiation de la traduction chez les eucaryotes est un oncogène puissant et qui se trouve induit dans plusieurs types de cancers, parmi lesquels les sous-types M4 et M5 de la leucémie aiguë ... Voir le document complet
154
Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients
... inherent in retrospective registry-based studies by studying a large patient cohort, by double-checking the RIC/ MAC information and by using early NRM as primary endpoint for estimating the impact of TCI, ... Voir le document complet
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Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells -high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation
... preparation of primary AML cells The study was approved by the Regional Ethics Committee III, University of Bergen, ...selections of patients as well as the analysis of FLT3 and NPM1 ... Voir le document complet
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Survival improvement of secondary acute myeloid leukemia over time: experience from 962 patients included in 13 EORTC-Gimema-HOVON leukemia group trials
... Secondary acute myeloid leukemia (sAML) describes patients (pts) with a history of malignant or non-malignant disease or AML secondary to environmental, occupational or therapeutic ...use ... Voir le document complet
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Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3internal tandem duplication: A position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
... lack of a clear cut-off (0.5 in the ELN recommendations, 0.7 in the RATIFY study) and the potential variability of the allelic ratio over ...the FLT3-ITD allelic ratio, making it ... Voir le document complet
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