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[PDF] Top 20 Expression analysis of novel striatal-enriched genes in Huntington disease

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Expression analysis of novel striatal-enriched genes in Huntington disease

Expression analysis of novel striatal-enriched genes in Huntington disease

... selection of our candidate gene list. Unlike the Mouse Atlas of Gene Expression and AIBS data sets, multiple animals were tested, resulting in a more robust analysis of ... Voir le document complet

14

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

... HD disease signature based on tran- scriptomics data to be used for drug development and disease progression biomarkers should be present in both blood and brain [13, ...Network Analysis ... Voir le document complet

14

Chromosomal profiles of gene expression in Huntington's disease.

Chromosomal profiles of gene expression in Huntington's disease.

... domains of repressed transcription co-exist with sizeable domains of increased ...activity of a large number of transcripts, that has been previously reported (Borovecki et ...example, ... Voir le document complet

11

Brain Regions Showing White Matter Loss in Huntington’s Disease Are Enriched for Synaptic and Metabolic Genes

Brain Regions Showing White Matter Loss in Huntington’s Disease Are Enriched for Synaptic and Metabolic Genes

... Enrichment of Genes Showing Abnormal Transcription in HD Is Seen in the Corticostriatal and Interhemispheric Gene Expression Pro files Our next step was to assess whether genes ... Voir le document complet

11

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

... powerful expression array platforms that identified a set of genes that showed a differential regu- lation between YAC128 and ...controls. In total, we evaluated expression of 13 ... Voir le document complet

15

Gene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma.: Novel cancer-testis genes in multiple myeloma

Gene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma.: Novel cancer-testis genes in multiple myeloma

... Gene expression profiling analysis All gene expression data were normalized with the MAS5 algorithm using the same global scaling and analyzed with our bioinformatics platforms (RAGE, ...assignment ... Voir le document complet

16

Characterization of genes with increased expression in human glioblastomas.

Characterization of genes with increased expression in human glioblastomas.

... rRNA in polyps of familial polyposis coli patients [16] ...levels of ATP6, ND5, cytochrome b, COXI, and COXII mRNAs were revealed in papillary thyroid carcinomas as compared to normal thyroid ... Voir le document complet

9

Neurobiology of Disease Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease

Neurobiology of Disease Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease

... Opsin striatal expression and lesion ...solution of paraformaldehyde 4% in ...overnight in the same fixative at 4°C, cryo- protected in 30% sucrose dissolved in 1& PBS ... Voir le document complet

13

Genetic load determines atrophy in hand cortico-striatal pathways in presymptomatic Huntington’s disease

Genetic load determines atrophy in hand cortico-striatal pathways in presymptomatic Huntington’s disease

... developed in Nipype (Gorgolewski et ...tractography analysis on large-scale multi-center diffusion- weighted ...distortions in diffusion-weighted imaging data and provide precise anatomical labeling ... Voir le document complet

34

Striatal Shape Alteration as a Staging Biomarker for Parkinson's Disease

Striatal Shape Alteration as a Staging Biomarker for Parkinson's Disease

... alterations in subcortical structures aside from volume or thickness reduction has long been identified as a potential area of ...category of Surface-based Morphometry (SBM) which is a two-stage ... Voir le document complet

15

Genome-wide expression profiling, in vivo DNA binding analysis, and probabilistic motif prediction reveal novel Abf1 target genes during fermentation, respiration, and sporulation in yeast.

Genome-wide expression profiling, in vivo DNA binding analysis, and probabilistic motif prediction reveal novel Abf1 target genes during fermentation, respiration, and sporulation in yeast.

... component of the regulatory network controlling mitotic and meiotic cell cycle progression in budding ...part of distinct protein complexes, but its roles during mitotic growth and meiotic ... Voir le document complet

16

Identification of 28 novel mutations in the Bardet-Biedl syndrome genes: the burden of private mutations in an extensively heterogeneous disease.

Identification of 28 novel mutations in the Bardet-Biedl syndrome genes: the burden of private mutations in an extensively heterogeneous disease.

... 75% of families, suggesting that mutations in known genes have not yet been detected by current investigations and/or that additional BBS genes remain to be ...that in rare cases, ... Voir le document complet

18

Expression and amplification of therapeutic target genes in retinoblastoma

Expression and amplification of therapeutic target genes in retinoblastoma

... included in these studies. However, the lack of muta- tions in exon 11 found in our sequenced strongly positive tumors may argue against a favorable response to imatinib ...occurs in ... Voir le document complet

7

Association study of cholesterol-related genes in Alzheimer's disease

Association study of cholesterol-related genes in Alzheimer's disease

... association of HMGCS2, FDPS, NPC2, and ABCG1 with AD in at least one ...problem of replication failure and inconsistency in case control association ...positivity of the original ... Voir le document complet

10

Steady-state expression of self-regulated genes

Steady-state expression of self-regulated genes

... consisting in a self-regulated gene, which is a building block of many gene ...simulations of many random trajectories. We present a novel strategy to determine analytically the ...network ... Voir le document complet

8

Involvement of D1 dopamine receptor in MDMA-induced locomotor activity and striatal gene expression in mice.

Involvement of D1 dopamine receptor in MDMA-induced locomotor activity and striatal gene expression in mice.

... RT-PCR analysis Mice were injected with SCH23390 ...frozen in isopentane at −50°C, and placed in an acrylic matrix (David Kopf Instruments, Tujunga, CA, USA) allowing the reproducible slicing ... Voir le document complet

11

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia

... Gene expression signatures associated with these two phenotypes could be essential for islet function and pathophysiology of type 2 diabetes ...a novel approach to identify candidate genes ... Voir le document complet

11

Differential Responses to Wnt and PCP Disruption Predict Expression and Developmental Function of Conserved and Novel Genes in a Cnidarian

Differential Responses to Wnt and PCP Disruption Predict Expression and Developmental Function of Conserved and Novel Genes in a Cnidarian

... identify genes potentially involved in Clytia embryogenesis without favoring gene families identified as developmental regulators from bilaterians, we compared transcriptomes at the onset of ... Voir le document complet

24

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice

... Institute of Technology, Cambridge, MA 02139 Contributed by David ...impact of a potential therapeutic intervention for Huntington disease (HD) in animal models for the disease ... Voir le document complet

7

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice

... Institute of Technology, Cambridge, MA 02139 Contributed by David ...impact of a potential therapeutic intervention for Huntington disease (HD) in animal models for the disease ... Voir le document complet

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