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[PDF] Top 20 Evaluating DNA damage response (DDR) activation in human prostate cancer

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Evaluating DNA damage response (DDR) activation in human prostate cancer

Evaluating DNA damage response (DDR) activation in human prostate cancer

... “DNA damage foci” are hallmarks of DDR activation 8; 22 ...to DNA damage foci, while H2AX is a histone that becomes phosphorylated at sites of DNA damage (named p- H2AX ... Voir le document complet

150

Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

... role in mediating DSB signal transduction for DDR initiation (Figure 3, Figure ...disease in A-T patients has been proposed to stem from the deregulation of the immune response leading to ... Voir le document complet

27

Human RAP 1 specifically protects telomeres of senescent cells from DNA damage

Human RAP 1 specifically protects telomeres of senescent cells from DNA damage

... factor in mammals have been reported. Indeed, mouse and human telomeres lacking RAP1 did not develop DNA damage response activation [5,6] but were prone to recombination by ... Voir le document complet

15

CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells

CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells

... Measuring DNA Damage in Microarrayed Human ...Abstract DNA damaging agents can promote aging, disease and cancer and they are ubiquitous in the environment and produced ... Voir le document complet

12

Lxrα regulates the androgen response in prostate epithelium

Lxrα regulates the androgen response in prostate epithelium

... profiles in lxr ␣ ⫺/⫺ mouse ...increases in mice lacking Lxr ␣, calr remains unchanged and pbsn de- ...cells in Fig. 8. Prostate mesenchymal-epithelial interactions have a preponderant role ... Voir le document complet

14

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells

... educed in ternalization of CN Ts ...clathr in-mediated endocy tosis ...sorting in the ear ly e ndosomes (co-loca lization wi th E ...equestrated in th e l ysosomes, a s confirmed by Lamp2 and ... Voir le document complet

14

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells

... educed in ternalization of CN Ts ...clathr in-mediated endocy tosis ...sorting in the ear ly e ndosomes (co-loca lization wi th E ...equestrated in th e l ysosomes, a s confirmed by Lamp2 and ... Voir le document complet

13

Evaluating ZNF217 mRNA Expression Levels as a Predictor of Response to Endocrine Therapy in ER+ Breast Cancer

Evaluating ZNF217 mRNA Expression Levels as a Predictor of Response to Endocrine Therapy in ER+ Breast Cancer

... du Cancer de Montpellier, University of Montpellier, Montpellier, France, 7 Département de Chirurgie Oncologique, Institut du Cancer de Montpellier, University of Montpellier, Montpellier, France ZNF217 is ... Voir le document complet

7

Prediction of response to recombinant human erythropoietin in the anemia of cancer

Prediction of response to recombinant human erythropoietin in the anemia of cancer

... or in the course of the disease (Beguin 1996; Knight et ...recombinant human erythropoietin (rhEPO) alfa or beta or darbepoietin alfa, can ameliorate the anemia associated with cancer and ... Voir le document complet

42

Dutastéride pour éviter un cancer de la prostate ?

Dutastéride pour éviter un cancer de la prostate ?

... d’un cancer prostatique chez des hommes à risque élevé est ...d’un cancer sous dutastéride dans des biopsies systématiquement réalisées à 2 et 4 ...un cancer prostatique (NST calculé par nos soins) ; ... Voir le document complet

16

Cell-cycle-dependent transcriptional and translational DNA-damage response of 2 ribonucleotide reductase genes in S. cerevisiae

Cell-cycle-dependent transcriptional and translational DNA-damage response of 2 ribonucleotide reductase genes in S. cerevisiae

... damage, cells exhibited induction of RNR1, RNR2 and RNR3 mRNA in α-factor arrested G1 187... cells with northern blot measurements (14, 15), leading to the conclusion that RNR gene 1[r] ... Voir le document complet

27

Aneuploidy drives lethal progression in prostate cancer

Aneuploidy drives lethal progression in prostate cancer

... Prostate cancer is an ideal cancer to study the impact of an- euploidy on disease progression because aneuploidy is relatively rare in this tumor type (3, 4) and the clinical course is highly ... Voir le document complet

7

Human breast cancer cells educate macrophages toward the M2 activation status

Human breast cancer cells educate macrophages toward the M2 activation status

... breast cancer cell-secreted factors, providing evidence for the mechanisms of breast cancer macrophage education be- hind clinical ...TAM activation in breast cancer pa- tients could be ... Voir le document complet

15

Chromatin Dynamics upon DNA Damage

Chromatin Dynamics upon DNA Damage

... reported in the literature varies from 5 × 10 −5 to 10 −3 μm 2 /s depending on the organ- isms, the loci studied, and the type of damage [66, ...67]. In several studies, chromatin undergoes confined ... Voir le document complet

22

Bisphenol A stimulates human prostate cancer cell migration via remodelling of calcium signalling

Bisphenol A stimulates human prostate cancer cell migration via remodelling of calcium signalling

... entry in BPA-induced cell migration We showed that Orai1 protein was up-regulated due to BPA treatments of the LNCaP cells and that Orai1 was involved in the amplification of the calcium entry into these ... Voir le document complet

17

Interferon-Alpha Promotes Th1 Response and Epithelial Apoptosis via Inflammasome Activation in Human Intestinal Mucosa

Interferon-Alpha Promotes Th1 Response and Epithelial Apoptosis via Inflammasome Activation in Human Intestinal Mucosa

... the human normal intestinal epithelial barrier with the presence of apoptotic bodies within the crypts and epithelial cells that shed at the surface and crypt ...individuals. In fact, some intestinal ... Voir le document complet

11

Novel Role of Cold/Menthol-sensitive Transient Receptor Potential Melastatine Family Member 8 (TRPM8) in the Activation of Store-operated Channels in LNCaP Human Prostate Cancer Epithelial Cells

Novel Role of Cold/Menthol-sensitive Transient Receptor Potential Melastatine Family Member 8 (TRPM8) in the Activation of Store-operated Channels in LNCaP Human Prostate Cancer Epithelial Cells

... (1:200) in PBS-gelatin for 1 h at 37 °C. After thorough washes in PBS-gelatin, the slides were treated with the corresponding Alexa Fluor 546-labeled anti-rabbit IgG (A-21206, Molecular Probes, using the ... Voir le document complet

14

Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.

Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.

... localization in the plasma ...mean±s.e.m) in the control (HEK-293/pEGFP, filled circles, n=4) and TRPM8-expressing (HEK-293/pEGFP-TRPM8, open circles, n=6) HEK-293 cells during exposure to menthol (100 μM, ... Voir le document complet

25

A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response

A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response

... What is the molecular basis for the observed chromatin association of FMRP? FMRP contains an N-terminal Agenet domain (Agenet FMRP ), which is a double-tudor domain that belongs to the Royal family of chromatin binding ... Voir le document complet

27

Electrical discharges in water induce spores' DNA damage

Electrical discharges in water induce spores' DNA damage

... involved in many human diseases, such as infectious diarrhea, fatal paralytic illnesses and respiratory infec- ...involved in the death of Bacillus pumilus spores after exposure to electric arcs ... Voir le document complet

16

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