[PDF] Top 20 Estimating the dynamics and dependencies of accumulating mutations with applications to HIV drug resistance
Has 10000 "Estimating the dynamics and dependencies of accumulating mutations with applications to HIV drug resistance" found on our website. Below are the top 20 most common "Estimating the dynamics and dependencies of accumulating mutations with applications to HIV drug resistance".
Estimating the dynamics and dependencies of accumulating mutations with applications to HIV drug resistance
... Beerenwinkel and Sullivant (2009) assumed that the sampling time for a given genotype is an unknown exponentially distributed random variable and is independent of the mutational ...in ... Voir le document complet
14
HIV-1 Reverse Transcriptase Connection Domain Mutations: Dynamics of Emergence and Implications for Success of Combination Antiretroviral Therapy
... showing dependencies in the emergence of resistance ...combination with didanosine or lamivudine. A directed arrow between 2 mutations (eg, M184V and N348I) or between an ... Voir le document complet
9
Assessing the Paradox Between Transmitted and Acquired HIV Type 1 Drug Resistance Mutations in the Swiss HIV Cohort Study From 1998 to 2012
... influx of new therapy options. This highlights the importance of a drug pipeline that constantly delivers new ...limitations to this study. Although our study was limited to a ... Voir le document complet
11
HIV resistance to raltegravir
... ROPERTIES OF RAL R ESISTANCE M UTATIONS The dynamics of HIV evolution under pharmacologi- cal pressure by RAL in vivo are largely explained by the phenotypic properties of ... Voir le document complet
9
Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: Findings from a cross-sectional study
... Background: The national antiretroviral therapy in the Republic of Chad provides free of charge antiretroviral regi‑ mens and therapeutic monitoring for patients receiving ... Voir le document complet
10
Quantifying the Evolution and Impact of Antimalarial Drug Resistance: Drug Use, Spread of Resistance, and Drug Failure over a 12-Year Period in Papua New Guinea
... 4. The size of the selective sweep in the genome surround- ing a mutation being selected for resistance ...[32]. The estimates for s given in Table 1 can therefore be used ... Voir le document complet
9
Surveillance of Transmitted HIV-1 Drug Resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009
... One of the limitations of the study was the low frequency of PCR amplification of specimens, particularly those from KZN, which compromised the assessment of ... Voir le document complet
5
Alternative methods to analyse the impact of HIV mutations on virological response to antiviral therapy.
... techniques with the construction of a genotypic score because they allow considering each mutation with a different ...weight. The objective of PCA is to find a set ... Voir le document complet
26
Simplified analytical method for estimating the resistance of lock gates to ship impacts
... However, the rotational movement of the triangular surfaces is not free because it must respect the compatibility between surfaces Cj and Chj along their common line ...Cj and ... Voir le document complet
39
Genome-Wide Association Study of HIV Whole Genome Sequences Validated using Drug Resistance
... proof of concept on the use of GWAS within HIV and other viruses whole genome sequence ...data. The smaller genome size, compared to humans, means that substantially ... Voir le document complet
15
Update on World Health Organization HIV Drug Resistance Prevention and Assessment Strategy: 2004-2011
... prevention of mother-to-child transmission is scaled up, fewer children are expected to become infected with HIV, but for those who do, a substantial proportion will be expected ... Voir le document complet
5
Treatment-Naive Individuals Are the Major Source of Transmitted HIV-1 Drug Resistance in Men Who Have Sex With Men in the Swiss HIV Cohort Study
... representativeness of the sur- veillance population, we do not have GRTs for the entire epidemiologic network included in the study ( patients not in- cluded in the SHCS-DRDB, not ... Voir le document complet
10
Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir.
... Abstract Mutations within the Hepatitis B virus (HBV) polymerase gene conferring drug- resistance are selected during prolonged lamivudine (3TC) or adefovir dipivoxil (ADV) ...approved ... Voir le document complet
29
Profiling the Non-genetic Origins of Cancer Drug Resistance with a Single-Cell Functional Genomics Approach Using Predictive Cell Dynamics
... UBE2D4, and UQCC3, could be specifically perturbed to increase cell sensitivity to death receptor ...found to participate to the fast phenotypic switching between resistant ... Voir le document complet
29
Treating symptomatic infections and the co-evolution of virulence and drug resistance
... ways to test the predictions of this ...be to use an experimental system where treatment can be applied to hosts based on the symptoms they ...requires to have hosts large ... Voir le document complet
31
Virological failure after 1 year of first-line ART is not associated with HIV minority drug resistance in rural Cameroon
... minority drug-resistance mutations were detected by next-generation sequencing at baseline in a substan- tial proportion of patients but were not associated with virological failure ... Voir le document complet
4
Numerical analysis of dislocations dynamics and applications to homogenization
... L’architecture du pr´esent document qui fait la synth`ese de mes travaux de recherche durant la p´eriode de th`ese, s’articule sur trois parties. La premi` ere partie (chapitres 2,3 et 4) est d´edi´ee `a la ... Voir le document complet
167
The dynamics of university units as a multi-level process. Credibility cycles and resource dependencies
... relevant to ask under which conditions the interaction between institutional and external funding might work differently, and when the incentives to acquire external funds may be ... Voir le document complet
23
Incidence of HIV-1 Drug Resistance Among Antiretroviral Treatment-Naive Individuals Starting Modern Therapy Combinations
... NNRTI resistance ( Supplementary Table 1; online only), thus considerably above levels of transmitted resistance in Switzerland [ 17 ...inspection of treatments and longitudinal CD4 ... Voir le document complet
10
Estimating the Jacobian of the Singular Value Decomposition : Theory and Applications
... Introduction and Motivation The SVD is a general linear algebra technique that is of utmost importance for several computations involving ...some of the uses of SVD include its ... Voir le document complet
25
Sujets connexes