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[PDF] Top 20 Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

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Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

... RESULTS Rac1 activity is increased in aSMC from patients with severe asthma To validate the potential role of Rac1 in airway remodelling ... Voir le document complet

11

Role of ADAM and ADAMTS metalloproteinases in airway diseases

Role of ADAM and ADAMTS metalloproteinases in airway diseases

... key role in asthma-associated airway remod- eling since the purified catalytic domain of this proteinase provokes an increased development of the vascular net- work ... Voir le document complet

12

View of Magnesium Sulfate and Helium–Oxygen for Severe Acute Asthma

View of Magnesium Sulfate and Helium–Oxygen for Severe Acute Asthma

... therapy of potential interest in acute severe ...purpose of this review is to identify their indications in acute severe ...a role in smooth muscle ... Voir le document complet

9

Impaired training-induced angiogenesis process with loss of pericyte-endothelium interactions is associated with an abnormal capillary remodelling in the skeletal muscle of COPD patients

Impaired training-induced angiogenesis process with loss of pericyte-endothelium interactions is associated with an abnormal capillary remodelling in the skeletal muscle of COPD patients

... subject of origin to avoid the inflation of Type I error [ 35 ...normality of the residual distribution was assessed by a Q-Q plot after each lme test [ 37 ... Voir le document complet

13

LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation

LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation

... Evaluation of inflammation, senescence and calcification/transdifferentiation in LMNA-transfected and PI-treated ...angiography in a 42 year-old patient harboring a ...quantifications of (B) ... Voir le document complet

36

Assessment of the potential role of 
muscle spindle mechanoreceptor afferents in chronic muscle pain in the rat
masseter muscle

Assessment of the potential role of muscle spindle mechanoreceptor afferents in chronic muscle pain in the rat masseter muscle

... phase of the oscillations in DRG and NVmes depends on a voltage-sensitive persistent inward sodium current (I Nap ) [21], while the repolarizing phase requires an outward potassium ...blockers of ... Voir le document complet

21

Serum club cell protein 16 is associated with asymptomatic airway responsiveness in adults: Findings from the French epidemiological study on the genetics and environment of asthma

Serum club cell protein 16 is associated with asymptomatic airway responsiveness in adults: Findings from the French epidemiological study on the genetics and environment of asthma

... study of adult and childhood asthma ...recruited in 5 chest clinics, 1244 first-degree relatives of cases, and 415 population-based controls were recruited (total, n= ...follow-up of ... Voir le document complet

43

Smooth muscle of the male pelvic floor: an anatomic study

Smooth muscle of the male pelvic floor: an anatomic study

... contains smooth muscle (SM) cells. This compartment is in close relation with the levator ani muscle (LAM), rectum, and ...part of the middle compartment posterior to the rectal wall ... Voir le document complet

39

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

... The Severe Asthma Research Program (SARP)-3 is a 3-year longitudinal cohort study in which 60% of subjects have severe asthma ...[11]. Severe asthma was defined ... Voir le document complet

38

Chronic oral corticosteroids use and persistent eosinophilia in severe asthmatics from the Belgian severe asthma registry

Chronic oral corticosteroids use and persistent eosinophilia in severe asthmatics from the Belgian severe asthma registry

... those in whom comorbidities had been ...point of recruitment into the ...mixture of molds) or a positive skin prick test. An exacerbation in the previous year was defined by a course of ... Voir le document complet

11

CD70 Deficiency Associated With Chronic Epstein-Barr Virus Infection, Recurrent Airway Infections and Severe Gingivitis in a 24-Year-Old Woman

CD70 Deficiency Associated With Chronic Epstein-Barr Virus Infection, Recurrent Airway Infections and Severe Gingivitis in a 24-Year-Old Woman

... seen in our patient were described in CD70-deficient patients before, ...recurrent airway infections, chronic EBV infection, EBV-mediated lymphoproliferation, hypogammaglobuliemia, decreased ... Voir le document complet

11

Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

... levels in patients with Group III PH ( Garcia-Morales et ...inhibition of Adora2b subdued both the fibrotic deposition and the development of PH in a mouse model of chronic bleomycin ... Voir le document complet

19

Essential role for Schizosaccharomyces pombe pik1 in septation

Essential role for Schizosaccharomyces pombe pik1 in septation

... This publication could be one of several versions: author’s original, accepted manuscript or the publisher’s version. / La version de cette publication peut être l’une des suivantes : la version prépublication de ... Voir le document complet

41

View of Severe Toxicities Associated with Cancer Immunotherapy

View of Severe Toxicities Associated with Cancer Immunotherapy

... le muscle (TVNIM) de risque intermédiaire ou haut [4], les greffes de moelle, via les cellules souches hématopoïétiques (CSH) ou le sang du cordon dans le cadre des allogreffes depuis 1957, qui est également un ... Voir le document complet

15

Predictors of a good response to inhaled corticosteroids in obesity-associated asthma

Predictors of a good response to inhaled corticosteroids in obesity-associated asthma

... number of ob- servations and percentages were given in each ...divided in three groups according to tertiles (< 400, ≥400-1000, ...all in- dependent ... Voir le document complet

6

Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults.

Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults.

... course in order to ensure appropriate patient selection and optimal asthma control prior to bronchial thermoplasty and during the entire treatment ...can, in fact, lead to temporary worsening ... Voir le document complet

9

Regulation of the Early Growth Response Protein-1 in vascular smooth muscle cells

Regulation of the Early Growth Response Protein-1 in vascular smooth muscle cells

... ISCUSSION In this study, we have demonstrated that β-adrenergic receptor activation of VSMC by ISO suppressed both protein and mRNA expression of Egr-1 induced by ...levels in the cells, as ... Voir le document complet

196

Continuous positive airway pressure improves gait cognitive control in severe obstructive sleep apnoea

Continuous positive airway pressure improves gait cognitive control in severe obstructive sleep apnoea

... with severe OSA syndrome (apnoea-hypopnea index, AHI > 30 events·hour -1 ) and (4) naïve of CPAP ...patients in order to ensure that they were free of sleep ...presence of central or ... Voir le document complet

58

&lt;p&gt;Two-Year Integrated Efficacy And Safety Analysis Of Benralizumab In Severe Asthma&lt;/p&gt;

<p>Two-Year Integrated Efficacy And Safety Analysis Of Benralizumab In Severe Asthma</p>

... dissemination of sci- entific research documents, whether they are pub- lished or ...institutions in France or abroad, or from public or private research ... Voir le document complet

13

Role of vascular plasticity in muscle remodeling in the child

Role of vascular plasticity in muscle remodeling in the child

... events of necrosis-inflammation, they differ regarding ...results in focal capillary loss, perivascular inflammation, and muscle ischemia ...70% of the patients are responders to ... Voir le document complet

171

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