cancer, by vorinostat resulting in an upregulation of MICA protein levels and a better recognition of these tumor cells by innate immune cells and especially NK cells [118].

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of

In this study, we observed a strong overexpression of class IIa HDAC9, at the mRNA and protein levels, in the most aggressive human breast cancer cell lines (i.e. in basal

Nocodazole-arrested cells subsequently treated with HDACIs (SBHA or TSA) fail to accumulate cyclin B and associated cdk1 activity, suggesting that HDAC inhibition can induce exit

Histone deacetylase inhibitors (HDACi) present these defects, despite displaying promising anti-tumor properties on tumor cells in vitro and in in vivo models of cancer.. The

To test the functional role played by altered levels of acH3K14 in the NAc, groups of mice subjected to chronic (10 d) social defeat stress and nonstressed control mice were, on day

Schistosoma mansoni: Developmental arrest of miracidia treated with histone deacetylase inhibitors... Schistosoma mansoni: Developmental arrest of miracidia treated with

Parmi les facteurs interférant avec la prise en charge, une information médicale incomplète ou incorrecte (le testicule descendra seul, ou alors il fallait attendre jusqu’à

En effet, le tableau suivant (Tableau 2) montre un extrait du corpus de données Teruti montrant sa structuration. Outre le n° de la PRA, celui de la photographie et du point Teruti,

The fact that HDACi impede the expression of phagocytic receptors, the generation of oxygen- and nitrogen-reactive species, and the release of proin- flammatory cytokines provide

II.1 Histone Deacetylase Inhibitors (HDACi) induce the HPV-16 Long Control Region (LCR) transcriptional activity in transformed human cell

and we measure the amplitude of the detected signal as a function of the frequency (at one or several harmonics of the modulation), the cut-off frequency being related to the

This work will discuss the prospect of measuring the neutrino mass hierarchy (NMH), the order of the neutrino masses, by deploying a detector on the Mediterranean seafloor, at a

Convergence tarifaire : Malgré les propositions précises de la FHF, la DGOS semble une nouvelle fois privilégier une convergence tarifaire à sens unique,

Jérôme Corvisier, Vincent Lagneau, Emmanuel Jobard, Jérôme Sterpenich, Jacques Pironon.. To cite

Select the top-k combinations according to top-m aggregate scores.. Top-k,m

Nous pourrons revenir encore, dans une autre occasion sur ce procédé d’Intégration ; nous nous bornerous à observer, pour le.. présent, qne, comme on

Remarkably, the tumor properties of histone deacetylase inhibitors, consistent with their selective effect on pro-apoptotic genes involved in the intrinsic cell death pathway,