Haut PDF Dynamic epigenetic changes in immune responses to infection in human dendritic cells
Dynamic epigenetic changes in immune responses to infection in human dendritic cells
... important epigenetic mark in ...stable epigenetic modification, it is becoming increasingly viewed as a more dynamic process that involves both active methylation and demethylation ...
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Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells
... pyroptosis in other FcγR + cells (e.g. neutrophils) occurs in a host with HAdV NAbs during local or systemic injection of HAdV vectors is ...compared to the non-opsonized pathogen [ 100 ]. ...
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Bacterial infection remodels the DNA methylation landscape of human dendritic cells
... of immune-acti- vated TFs in response to ...regulators to hypomethylated regions is likely associ- ated with the opening of the chromatin in these regions, although it remains unclear ...
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Silent infection of human dendritic cells by African and Asian strains of Zika virus
... IFNs in MoDCs. Virus-infection of MoDCs is leading to the activation of antiviral innate immune mechanisms, with the IFN type I (IFN-α/β) pathway being of central importance to protect ...
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Epigenetic regulation of innate immune responses to infection
... of epigenetic modifications in the control of gene expression is widely ...altered epigenetic patterns themselves invoke transcriptional modulation or are instead downstream consequences of ...
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Acquired immune responses to the seasonal trivalent influenza vaccination in COPD
... mortality in chronic obstructive pulmonary disease (COPD) pa- ...defect in the ability of some COPD patients to mount an adequate humoral response to in- fluenza ...was to ...
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αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus
... modified to realize the graphical abstract ...Fellowship in Medicine, a Lundbeck Foundation Research Fellowship, the Åke Wiberg Foundation, the Carl Trygger Foundation and the Crafoord ...
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Differentiation of human dendritic cell subsets for immune tolerance induction
... capacity to secrete IL-10 for each subset obtained has been evaluated by ELISA ( ...due to stimulation. In presence of the pro-inflammatory stimulus, LPS or class A CPG-ODN, IL-12p70 or INF-alpha ...
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P11-05. Induction of CD8+ T cell mediated immune responses through skin and mucosa: identification of immunostimulatory versus tolerogenic dendritic cells
... that in vivo priming of CTL responses was induced by newly recruited DC rather than skin/mucosal resident ...Ag to CD8+ T ...LC in Langerin-DTR mice and the con- tact sensitizer DNFB (which ...
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Variability in the virulence of specific Mycobacterium tuberculosis clinical isolates alters the capacity of human dendritic cells to signal for T cells
... METHODS Human blood peripheral mononuclear cells, MD- DCs and T lymphocytes - Mononuclear cells were iso- lated from buffy coats provided by the State Blood Transfusion Center of Zacatecas, SSA ...
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Engineered niches support the development of human dendritic cells in humanized mice
... incubated in 34% sucrose solution (Sigma-Aldrich) overnight at 4 ...embedded in Cryomatrix (Thermo Fisher) and frozen for cryostat sectioning (9 ...For human DCs staining, plug sections were ...
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IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates
... Antibody Responses We then tested the capacity of IL-7 to serve as an adjuvant in a mucosal immunization protocol against a model ...DT in 200μL of PBS) sprayed directly into the vaginal ...
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IL-7-adjuvanted vaginal vaccine elicits strong mucosal immune responses in non-human primates
... HAL Id: hal-03000444 https://hal.archives-ouvertes.fr/hal-03000444 Preprint submitted on 11 Nov 2020 HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci- entific research documents, ...
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Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors
... used to treat melanoma, with very encouraging results, ICIs have been tested in many other tumor types with demonstrated clinical efficacy [ 2 ...lasting responses that translate into survival ...
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Role of DC-SIGN in Lassa Virus Entry into Human Dendritic Cells
... DC-SIGN in MDDC correlates with enhanced LASV ...susceptible to infection with different LASV isolates and that productive infection causes virus-induced perturbation of their ...
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The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells
... epidemics in South Pacific islands and Americas due to ZIKV association with severe damage to fetal brain development and neurological complications in adult ...undertaken to identify ...
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The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.
... hematopoietic cells. Mononuclear cells were isolated from cord blood (CRB Saint-Louis Hospital, Paris) or adult bone marrow donors with written informed consent for research use, in accordance with ...
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Studying the Immune Synapse in HIV-1 Infection.
... scholar in the Pasteur -‐ Paris University (PPU) International PhD program and is funded by the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme FP7/2007-‐2013/ under ...
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Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice
... decided in a second step to investigate the effect of Igf2 deficiency on the maturation and function of DC, the most potent APC (22) implicated in polarization of the immune response, ...iDC ...
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Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications.
... upregulated in GV and 2,000 in MII oocytes (Cui et ...signalling in mature MII oocytes. The focus of our previously published study was to apply a microarray approach to identify new ...
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