[PDF] Top 20 Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins
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Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins
... In Chapter 3, mutations in dDP are presented and used to examine the relationship between E2F-dependent G1-S transcription and S phase onset in vivo; the role of dDP and dE2F in cel[r] ... Voir le document complet
168
Direct non transcriptional role of NF-Y in DNA replication
... regulator of cell cycle genes [13, 53,54] : the analysis of gene expression pro filing of NF-Y-depleted HCT116 cells highlighted that several cell cycle genes were indeed ... Voir le document complet
14
Developmental regulation of DNA replication initiation in Drosophila
... amplification in the ovarian follicle cells of Drosophila provides a powerful system for the study of metazoan DNA ...gradients of amplified DNA through ... Voir le document complet
156
Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation
... understand the interplay be- tween these regulatory elements and quantify their re- spective roles in the regulation of transcriptional ...activity. The ... Voir le document complet
18
Genome-wide studies highlight indirect links between human replication origins and gene regulation.
... 30 origins have been mapped in human ...transcribed genes were analyzed, a genome-wide view of replication initiation was still ...lacking. The aim of the ENCODE ... Voir le document complet
7
en fr Identification of new mechanisms of temporal regulation of DNA replication origins in human cells Identification de nouveaux mécanismes de régulation temporelle des origines de réplication dans les cellules humaines
... uman DNA polymerase y (Pol y) is a 290-kDa protein that comprises a carboxy-terminal A-family polymerase domain, which performs template-dependent and -independent DNA synthesis in vitro 1,2 , ... Voir le document complet
176
Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins
... delineated the cis requirements for replication and found that a 6-kb minimal region is sufficient for origin ...Despite their diverse approaches, recent origin mapping studies have all found ... Voir le document complet
7
DNA Copy-Number Control through Inhibition of Replication Fork Progression
... control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and ... Voir le document complet
11
Role of the Polymerase ϵ sub-unit DPB2 in DNA replication, cell cycle regulation and DNA damage response in Arabidopsis
... displayed the same aphidicolin sensitivity and the same early flowering phenotype as abo4 /esd7 mutant lines that are deficient for the catalytic sub-unit ( 18 , 19 ...that the CFP-DPB2 ... Voir le document complet
17
Role of environmental factors in timing the onset and progression of puberty
... problems in trying to discover new genes which regulate puberty including defining a marker for ...find genes which initiate the process using non-invasive ...activation of genes ... Voir le document complet
9
Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy
... 3 of 19 alternative splicing can modify the affinity of the RTKs for their ligands, providing a specific signalling for each splice ...is the case for the fibroblast ... Voir le document complet
20
Role of the thalamus in basal forebrain regulation of neural activity in the primary auditory cortex
... Department of Medicine, Visual Cognition Laboratory, University of Fribourg, Chemin du Musée 5, Fribourg CH-1700, ...implicated the basal forebrain (BF) as a potent regulator of sensory ... Voir le document complet
15
Role of the tumor microenvironment in regulating apoptosis and cancer progression
... expression of the therapeutic target, or an induction of an alternative ...pathway. In addition, multidrug resistance has been established as a result of the presence of ... Voir le document complet
25
Organization of DNA replication origin firing in Xenopus egg extracts : the role of intra-S checkpoint
... In the MM5 model origins fire globally with two origin firing probabilities (𝑃 0 and 𝑃 0 + 𝑃 𝑑𝑜𝑚 ) eventually increased by a local origin firing probability (𝑃 𝑓 𝑜𝑟𝑘 ) close to an active fork, ... Voir le document complet
30
Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity
... acute and chronic nicotine administration. Especially at an early age, the network is prone to adapt ...use in humans often starts during puberty and is occurring during prolonged periods, it ... Voir le document complet
17
Cell cycle regulation of complex formation at origins of DNA replications
... Clb5 Associates with Origins of Replication in vivo 111 Cell cycle regulation of Clb5 association with Origins 116 Mutations that prevent Clb5 origin association do not inte[r] ... Voir le document complet
161
DNA-binding specificity of the E2F gene family, and cloning and characterization of a novel family mamber
... A function supplied by E2F-1 is therefore essential for efficient tumorigenesis in some contexts, indicating that the deregulation of E2F by mutagenesis of the pRB/ cyclin[r] ... Voir le document complet
178
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
... individual genes (Figure S4B). These data suggest that Topo IIβ-mediated DNA cleavage could underlie activity-induced DSB formation in ...neurons. Activity-Induced DNA DSBs Occur ... Voir le document complet
31
On the regulation, function, and localization of the DNA-dependent ATPase PICH
... (Chan and Hickson 2011; Hubner et ...2010), the data reported here contribute to clarify several important aspects of PICH function, regulation, and ...affect the functionality ... Voir le document complet
14
DNA replication in budding yeast : link between chromatin conformation and kinetics of replication
... Extraction of replicated fraction from a G1 blocked-and-released ...cells The progression through S phase of ...mediated G1 arrest was monitored by FACS (Figure.1). ... Voir le document complet
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