[PDF] Top 20 DPP-4 inhibitors in the management of type 2 diabetes: A critical review of head-to-head trials.

... (DPP-4) inhibitors offer new options for the management of type 2 ...comparators in drug-naive patients have demonstrated that DPP-4 ... Voir le document complet

... SGLT-2 inhibitors exert more favourable effects than placebo in 12 to 52-week trials, with an acceptable safety ...However, the most clinically relevant issue to position ... Voir le document complet

... effects of GLP-1 RAs on major cardiovascular events are currently being ...that in T2DM cardiovascular disease can be reversed or prevented by improving glycemic control is still incomplete, [60] large, ... Voir le document complet

... Department of Medicine, CHU Sart Tilman, Liège, Belgium ABSTRACT The pharmacological treatment of type 2 diabetes (T2DM) is becoming increasingly complex, especially since ... Voir le document complet

... The results suggest that 11 patients with IGT would need to be treated for ...years to prevent one event of development of ...risk of developing T2DM irrespective of age, ... Voir le document complet

... all of these properties is a nontrivial task, as they do not behave independently of each ...other. In fact, the task is challeng- ing enough that in the thirty plus years ... Voir le document complet

... In 2004, George et al. 5 reported 21 patients less than 50 years of age who had undergone the Darrach procedure for symptomatic DRUJ following fractures of the distal ...period  ... Voir le document complet

... contribution of the reflexive anaphora in this intensifying use of the prepositional reflexive? A clear semantic continuity, produced by a common semantic pattern, can be ... Voir le document complet

... Furthermore, the association of SGLT2 inhibitors with insulin, particularly for patients who gain considerable weight with insulin therapy and maintain high HbA 1c concentrations, appears to ... Voir le document complet

... objectives of phase III trials Phase III, or registrational trials, are intended for marketing ...Because of the unmet need in NASH therapy, the regulatory authorities ... Voir le document complet

... on a calcite statuette depicting the 6 See, notably, Sourouzian ...from the 6th Dynasty, see Romano ...provide a very useful list of known pieces of 5th-Dynasty royal sculpture ... Voir le document complet

... group in the apical position. The spin state change occurs in this ...Subsequently, the arrangements of the two acac ligands changes from planar to butterfly, ... Voir le document complet

... role in the tolerability of metformin and taking into account its polymorphism has been proposed for personalizing metformin therapy ...changes in plasma lactate levels were negligible and ... Voir le document complet

... Outcomes The outcomes analysed in the 13-study pool were overall AEs and serious AEs (SAEs), AEs occurring in ≥3% of the pooled population, and AEs of hypoglycaemia, renal ... Voir le document complet

... effect of ammonia on vascular function Chronic hyperammonemia is believed to decrease cGMP formation and thereby secondary signaling for NO, one of the main regulators of tonic ... Voir le document complet

... induced in Wistars rats by unilaterally clamping the left kidney for 60 ...minutes. The right kidney was simultaneously excised and used as ...and the kidney was removed straight after ... Voir le document complet

... with a dose-response relation in patients with type 2 ...support to results of earlier studies, an epidemiological study cannot show a causal relation, and such an ... Voir le document complet

... Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential ... Voir le document complet

... improvements in skeletal muscle mitochondrial function have already been studied in healthy subjects [28] and in insulin resistant patients, including type 2 diabetes mellitus ... Voir le document complet

... HOPE In the "Heart Outcomes Prevention Evaluation" (HOPE) study, a total of 9297 high-risk patients (55 years of age or older) who had evidence of vascular disease or ... Voir le document complet