[PDF] Top 20 DNA Copy-Number Control through Inhibition of Replication Fork Progression
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DNA Copy-Number Control through Inhibition of Replication Fork Progression
... Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and ... Voir le document complet
11
Developmental control of gene copy number by repression of replication initiation and fork progression
... nine of these are bound by SUUR (Makunin et ...absence of ORC and the presence of SUUR, replication ...on replication proteins or indirectly by affecting chromatin ...the ... Voir le document complet
14
Direct non transcriptional role of NF-Y in DNA replication
... that fork progression is impaired when NF-Y activity is abrogated, we performed DNA combing analysis on single cells: surpris- ingly, the velocity of ongoing replication forks ... Voir le document complet
14
XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition
... role of XAB2 in HR in the U2OS human osteosarcoma cell line, siRNA-mediated depletion of XAB2 resulted in a decrease in CPT- induced chromatin-bound RPA, as assessed by flow cytometry analysis, which was ... Voir le document complet
45
Dynamic changes in ORC localization and replication fork progression during tissue differentiation
... their DNA content via a modified cell cycle with solely G and S phases, the ...sister DNA helices are held in register to give a banded pattern in visible ...Differential DNA rep- lication occurs ... Voir le document complet
16
Low rate of replication fork progression lengthens the replication timing of a locus containing an early firing origin
... Invariance of temporal order of genome replication in eukaryotic cells and its correlation with gene activity has been ...relax control of replication timing. To evaluate ... Voir le document complet
13
Novel origins of copy number variation in the dog genome.
... variety of mechanisms are thought to give rise to CNVs [11]. A major source of structural variation is non-allelic homologous recombination (NAHR), which occurs due to aberrant pairing of regions ... Voir le document complet
42
Learning smoothing models of copy number profiles using breakpoint annotations
... end of a chromosome arm, and the genomic coordinates of these regions are given in Table ...definition of breakpoint annotations in Equation 2. Table 1 shows counts of annotations per region, ... Voir le document complet
15
Deciphering the chronology of copy number alterations in Multiple Myeloma
... rest of the study. We investigated the frequency and the order of copy number alterations in each HMM sample, using smoothed signals from Cytoscan HD pro- files, and merging p and q arms for ... Voir le document complet
11
Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number.
... See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/309367650 Replication Errors Made During Oogenesis Lead to Detectable De Nov[r] ... Voir le document complet
27
DNA replication in budding yeast : link between chromatin conformation and kinetics of replication
... Extraction of replicated fraction from a G1 blocked-and-released ...The progression through S phase of ...amount of DNA, x, was set to x=1 in G1 cells. A broad peak of ... Voir le document complet
285
Copy number variations in the gene space of Picea glauca
... transmission of the BT103424 (Unknown protein) and BT109608 (Chaperone DnaJ-domain protein) genes was subject to a maternal effect (and most likely have a gametic ...one- copy allele (A1) of both ... Voir le document complet
99
Developmental regulation of DNA replication in Drosophila melanogaster
... The mechanisms regulating DNA replication are conserved between mitotic cell cycles, endocycles and Drosophila follicle cell gene amplification.. A period of low Cyclin/Cdk, [r] ... Voir le document complet
153
A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma
... complex inversion –translocation events, and our approach was able to capture such translocations as well. Furthermore, in cases where both derivative chromosome breakpoints were captured, they often covered two ... Voir le document complet
10
Characterization of two Bacillus subtilis proteins required for the initiation, restart, and control of DNA replication
... The essential replication initiation factor DnaB from Bacillus subtilis is not an integral membrane protein The dnaBS371P allele causes a reduction in the ability of DnaB to multimerize [r] ... Voir le document complet
254
Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins
... In Chapter 3, mutations in dDP are presented and used to examine the relationship between E2F-dependent G1-S transcription and S phase onset in vivo; the role of dDP and dE2F in cel[r] ... Voir le document complet
168
Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines.
... mapping of open chromatin marks along U-domains revealed that they are bordered by early replication initiation zones likely specified by a *300 kb wide region of accessible, open chromatin ... Voir le document complet
15
Developmental regulation of DNA replication initiation in Drosophila
... cells of Drosophila provides a powerful system for the study of metazoan DNA ...gradients of amplified DNA through repeated rounds of origin firing and bidirectional ... Voir le document complet
156
DNA replication timing data corroborate in silico human replication origin predictions
... analyses of human chromo- some 6 [ 6(a) ] and 22 [ 6(b) ] have improved replication timing resolution from 1 Mbp down to 100 kbp using arrays of overlapping tile path ...representative of the ... Voir le document complet
4
A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp
... Institute of Technology, Cambridge, MA 02139 SUMMARY Toxin-antitoxin (TA) systems are ubiquitous on bacterial chromosomes, yet the mechanisms regulating their activity, and the molecular targets of toxins, ... Voir le document complet
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