[PDF] Top 20 Developmental control of the DNA replication and transcription programs

... Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA; 2 Department of Pharmacology and Cancer Biology, Duke University Medical ... Voir le document complet

... nine of these are bound by SUUR (Makunin et al. 2002). Thus despite the absence of ORC and the presence of SUUR, replication ...on replication proteins or ... Voir le document complet

... Spontaneous DNA Damage RBBP6 is an essential protein ( Li et al., 2007 ) and is deregulated in ...cells and monitored the cells for biological ...signs of DNA damage, as ... Voir le document complet

... prevents the initiation of replication [61] , or with Geminin, which targets the pre-RC component Cdt1, thus inhibiting DNA replication [62] ( ...B and Supplementary ... Voir le document complet

... length and centre-to-centre distances were also found to be shorter than in control cells ...because of differences in residual levels of ...IdU and CldU and the distance ... Voir le document complet

... analysis of the viral nucleic acid production throughout the replication cycle by qPCR and ...measured the effects of NC zinc finger and basic residue deletions ... Voir le document complet

... Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression ... Voir le document complet

... amount of mRNA using the Max- ima reverse transcriptase (Thermo Scientific) according to the manufacturer’s ...instructions. The RT reaction was processed as follow: 10 min at 25 °C, 15 min at ... Voir le document complet

... in the ovarian follicle cells of Drosophila provides a powerful system for the study of metazoan DNA ...gradients of amplified DNA through repeated rounds of origin ... Voir le document complet

... interactions of DPB2 func- tion with DDR The tolerance to different types of DNA damage that trig- ger replicative stress or DNA breaks, may be due to consti- tutive activation ... Voir le document complet

... ng/mL) and ATP (10 mM) for 15 min. at 30 °C. 10 μg of extracts were incubated with individual DUBs in 20 μL reaction buffer for 60 ...buffer and analysed by anti-HA western ...ORC3 and ORC5 ... Voir le document complet

... a—SLX4 and MUS81 SLX4 is a platform protein that recruits nucleases that resolve branched DNA intermediates resulting from HR and/or arrested replication fork ...SLX4 and plays a role ... Voir le document complet

... X-100 and protease inhibitors), as Fig. 5 ORC3 and ORC5 multi-mono-ubiquitylation is essential for origin ...ORC3 and ORC5 or lysine-less versions (0 K, see Supplementary Fig. 10a) and ... Voir le document complet

... 1 Replication forks are slower in the presence of the HTLV-I Tax ...Induction of Tax expression was associated with an increase in DNA breaks detected by FACS analyses of ... Voir le document complet

... Abstract DNA replication is a complex mechanism that functions due to the coordinated interplay of many ...In the last few years, numerous studies have suggested that DNA ... Voir le document complet

... geneity and replication events invisible to population assays, DNA combing-based RFD profiles allow the interrogation of models built on ensemble-averaging ...substantiate the ... Voir le document complet

... In Chapter 3, mutations in dDP are presented and used to examine the relationship between E2F-dependent G1-S transcription and S phase onset in vivo; the role of dDP and dE2F in cel[r] ... Voir le document complet

... throughout the day (AUC) and morning cortisol levels, but not with evening cortisol ...Interestingly, the latter appears to be more susceptible to environmental influences (Ancelin et ...provides ... Voir le document complet

... Protein + ATP Required For: Early Step (ATPase inhibited?) A Signal Then Triggers: 4 ATP Hydrolysis and Switch in Protein Activity + Origin Binding PreRC Assembly Origin Unwinding AD[r] ... Voir le document complet

... under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...major DNA repair pathway ... Voir le document complet