[PDF] Top 20 Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0
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Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0
... Abstract Nonlinear mixed effect models (NLMEM) with multiple responses are increasingly used in pharmacometrics, one of the main examples being the joint analysis of the ... Voir le document complet
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Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model.
... drug and its ...for multiple responses has not yet been ...as in the single response is used, computation can become more complicated for multiple ...included in several ... Voir le document complet
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Evaluation of bootstrap methods for estimating uncertainty of parameters in nonlinear mixed-effects models: a simulation study in population pharmacokinetics
... p in B Pη,PR and lower coverage rate of Q for the asymptotic ...method. In this study, we expected that the random effect and residual bootstrap would have good performance in ... Voir le document complet
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Design evaluation and optimization for models of hepatitis C viral dynamics
... pathogenesis and predicting treatment ...kinetics and changes in drug concentration after treatment initiation. In such complex models parameter estimation is challenging and ... Voir le document complet
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Extension of NPDE for evaluation of nonlinear mixed effect models in presence of data below the quantification limit with applications to HIV dynamic model.
... receipt and acceptance should be inserted later Abstract Data below the quantification limit (BQL data) are a common challenge in data analyses using nonlinear mixed effect ... Voir le document complet
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Influence of covariance between random effects in design for nonlinear mixed-effect models with an illustration in pediatric pharmacokinetics.
... matrix in PFIM software for covariance between random effects and to evaluate ...the evaluation, a comparison of the SEs of parameters predicted by PFIM and those given by two ... Voir le document complet
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Performance comparison of various maximum likelihood nonlinear mixed-effects estimation methods for dose-response models.
... (SAEM_NM and SAEM_MLX), and a second time with modified settings (SAEM_NM_tun and ...ISAMPLE=2 and IACCEPT=0.4, and with the number of iterations from the stochastic phase NBURN≤2000 ... Voir le document complet
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Parameter Estimation in Nonlinear Mixed Effect Models Using saemix, an R Implementation of the SAEM Algorithm
... properties in various theo- retical ( Kuhn and Lavielle ( 2005 )) and practical applications ( Girard and Mentr´ e ( 2005 ); Panhard and Samson ( 2009 ); Comets, Lavenu, and ... Voir le document complet
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Mixed behavior identification in nonlinear nanomechanical resonators
... the nonlinear behavior of resonators remains yet to be explored, and numerous models have been ...Some models are purely analytical [2, 3] but they include coarse assumptions con- ... Voir le document complet
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Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models
... studied in crossover design and can be analysed by nonlinear mixed effects models as an alternative to noncompartmental ...matrix in nonlinear mixed effects ... Voir le document complet
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Design Optimization in Nonlinear Mixed Effects Models Using Cost Functions: Application to a Joint Model of Infliximab and Methotrexate Pharmacokinetics: Designs in nonlinear mixed effects models
... complex models including fixed effects for the influence of covariates on the response and for an additional variability of the parameters of a given individual between several periods of treatment ... Voir le document complet
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Experimental evaluation and modeling of a nonlinear absorber for vibration attenuation : design, identification, and analysis
... explored in order to store and to dissipate the energy of ...presented in a bibliographical summary in Sections ...1.3 and 1.4. Methods and devices based for reducing vibration ... Voir le document complet
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Human-Centered Design and Evaluation of Haptic Cueing for Teleoperation of Multiple Mobile Robots
... enhanced in the conventional teleopera- tion [18], [19], [20], [21], ...change in the transmitted stiffness to the operator could be increased by tuning the control parameters of a teleoperation controller ... Voir le document complet
14
Estimating Shortwave Radiative Forcing and Response in Climate Models
... changes in energy storage (E ) and also horizontal energy transport (vE) in a column extending from the top of the atmosphere to below the earth’s ...(Q) and the negatively signed outgoing ... Voir le document complet
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Extension of the SAEM algorithm for nonlinear mixed models with 2 levels of random effects.
... non-linear mixed effects models (NLMEMs) increases in several fields such as agron- omy, forestry, clinical trials, population pharmacokinetics (PK) and pharmacodynamics or viral dynamics to ... Voir le document complet
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Bivariate linear mixed models using SAS proc MIXED.
... microglobuline). These markers are associated as the infection measured by HIV RNA induces inflammation and the destruction of immune cells. Several authors have developed methods to fit evolution of CD4 ... Voir le document complet
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Evaluation of Treatment Effect with Paired Failure Times in a Single-Arm Phase II Trial in Oncologyjavascript:void(0);
... distribution, and reproduction in any medium, provided the original work is properly ...cited. In early phase clinical trials of cytotoxic drugs in oncology, the efficacy is typically ... Voir le document complet
10
Algorithms and Software for Convex Mixed Integer Nonlinear Programs
... Strong-branching and pseudo-costs form a natural combination to solve each of the two methods drawbacks: strong- branching is to slow to be performed at every node of the tree, and pseudo- costs need to be ... Voir le document complet
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Editorial. 3(0) ans déjà !
... numéro 3 du volume 3 - arrive avec la fête de Noël, quelques jours avant le 30e colloque de l’ADMEE-Europe, après avoir soufflé ses 30 bougies en janvier dernier sur le lieu même de sa naissance, à Dijon, ... Voir le document complet
2
Handling Domain Knowledge in Design and Analysis of Design Models
... experts and several design models corresponding to different analyses (views) of the same ...(view) and second, by explicitly defining the required con- cepts and properties borrowed ... Voir le document complet
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