[PDF] Top 20 DECIPHERING CELL SIGNALING REWIRING IN HUMAN DISORDERS
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DECIPHERING CELL SIGNALING REWIRING IN HUMAN DISORDERS
... (TNBC) cell lines were studied for their sensitivity to Dbait (DT01) and the PARP inhibitor Olaparib showing wide distribution of responsiveness to these drugs, that in many cases in not correlated ... Voir le document complet
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Deciphering the uranium target proteins in human dopaminergic SH-SY5Y cells
... Advances in the description of metalloproteomes provide a better understanding of the mechanism and precise role of metalloproteins in the brain (Lothian et ...proteins in neuronal cells exposed to ... Voir le document complet
20
Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders
... Notch in various mechanisms that greatly contribute to the pathogenesis of ...plays in macrophages, central to the development of inflammation and atherosclerosis, was recently ...ligands in ... Voir le document complet
27
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
... AKT signaling results differ from studies in which mutant PIK3CA was expressed ectopically in cell culture/chick embryo models ( Isakoff et ...AKT signaling is reduced in many ... Voir le document complet
13
Deciphering anti-HCMV HLA-E-restricted unconventional CD8 T-cell responses in seropositive HCMV+ hosts
... ① Detection of HLA-E UL40 CD8 T cells in blood samples ② A set of 11 HLA-E tetramers loaded with UL40 SP 1. Starting point: A specific & sensitive assay 2. Detection of anti-HCMV HLA-E-restricted CD8 T cells ... Voir le document complet
2
Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders.
... milk in Tris Buffer ...4ºC in the same blocking solution supplemented with the appropriate anti- phospho-specific ...50ºC in buffer containing 100mM 2-Mercaptoethanol, 2% (weight/vol) SDS, ...washing ... Voir le document complet
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Bisphenol S Impaired Human Granulosa Cell Steroidogenesis In Vitro
... performed in follicular fluid with assays performed in ...occurred in this study, related to the use of human granulosa cells from women undergoing IVF ...studied in an oestrogenic ... Voir le document complet
21
The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate
... induction in positively selected thymocytes Thpok expression is primarily regulated at the transcriptional level, as evidenced from the tight coordination between Thpok transcription and translation [268, ... Voir le document complet
230
Kinome rewiring during acquired drug resistance in neuroendocrine neoplasms
... involved in differentiated functions ( Ardito et ...signature in terms of kinase activity profiles (Supplementary Fig. 1). NENs cell lines also displayed lower Tyr-kinase and higher Ser/Thr-kinase ... Voir le document complet
14
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to Human cell glioblastoma apoptosis by platinum-maurocalcin conjugate
... promoter in order to promote Bim transcription. As shown in Figure 4A and B, Pt-1-DMCa treatment in U87 cells enhances FoxO3a binding to the Bim promoter thereby raising transcription levels ... Voir le document complet
26
Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies.
... nuclei. In contrast, recombinant hCG induced the differentiation of T21 CT into an ...than in normal placenta, suggesting that their maturation or differentiation is ...expression in human ... Voir le document complet
24
Deciphering human activities in complex urban systems : mining big data for sustainable urban future
... * How can big urban sensing data be mined to reveal differences in individual activity and mobility patterns, and be translated from individual human activities to met[r] ... Voir le document complet
200
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
... α-IgM-induced signaling depends on signaling strength The strength of α-IgM-induced signaling in MCL could potentially affect the suppressing efficacy of BCR signaling ...measure ... Voir le document complet
31
Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.: PtdIns5P and T cell signaling
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ... Voir le document complet
2
Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models
... cilia signaling is likely to influence neuronal behavior via both rapid local signaling cascade changes as well as by triggering changes in transcriptional programs underlying neuronal growth and ... Voir le document complet
39
Deciphering myeloid-derived suppressor cells isolation and markers in humans, mice and non-human primates
... Whereas in humans and non- human primates (NHP) MDSC are primarily characterized in the blood, in mice these cells are often investigated in a tissue context, besides a few exceptions [ ... Voir le document complet
12
Cytokine-associated drug toxicity in human hepatocytes is associated signaling network dysregulation
... “predicts”the cell death responses by multiplying the experimental signaling measurements with the model regression coefficients, and then calculating model fitness 28 , 29 by comparing the “predicted”and ... Voir le document complet
21
Importance of AJ and cell polarity in the regulation of Fas signaling
... of cell sorting: the ability of “like” cells to form discrete populations with one another, the ability of “un- FIG ...cadherins in tissue integrity. A: cadherin function in stratifying epithelium of ... Voir le document complet
226
RNA Splicing, Cell Signaling and Response to Therapies
... lesions in non-replicating cells control alternative splicing through chromatin displacement of spliceosome, formation of R-loops and activation of a non-canonical ATM signaling ... Voir le document complet
23
TGFβ signaling curbs cell fusion and muscle regeneration
... Cell motility is therefore required to bring pre-fusing cells into ...TGFβ signaling impacts muscle cell motility and contact using live ...high cell density would have impeded a clear ... Voir le document complet
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