[PDF] Top 20 Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML
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Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML
... downstream signaling pathways in order to i) prevent potential resistance mechanisms to inhibition of the metabolic targets and ii) nominate combination therapies that may synergize with ... Voir le document complet
10
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
... challenge in cancer ...present in these transcription-factor driven ...liability in EVI-positive AML. In considering the clinical translation of this finding, it is notable that ... Voir le document complet
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Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation
... a positive regulator of b-catenin As demonstrated above, GRA18 interacts with well-known components of the b-catenin destruction complex, a multiprotein complex with a pivotal role in the Wnt ...the ... Voir le document complet
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Genetic association study of plasma creatine kinase levels in the Montreal Heart Institute Hospital Cohort
... reports in clinical trials Data from systematic reviews, meta-analyses, clinical trials, and post marketing surveillance indicate that statin-associated myalgia typically affects around ...myopathy ... Voir le document complet
123
MicroRNA therapy inhibits hepatoblastoma growth in vivo by targeting β-catenin and Wnt signaling
... measured in parallel to assess the rele- vance of MRX34 (miR-RX34)-based therapy in ...shown in Fig. 3A, miR-34a-5p was not deregulated in HBL compared to NL and was slightly increased ... Voir le document complet
17
Understanding the interactions between Wnt and BMP signaling pathways in human Periosteum Derived Cells
... of Wnt (β-catenin) and BMP (P-Smad) pathways for three different conditions: presence of Wnt only (C1), BMP only (C2) and both (C3) and for one particular crosstalk configuration ... Voir le document complet
1
Phosphoinositide 3-Kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
... B.M., and Downward, J. (1998). Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel ...Function and Protects against Metabolic Disease by ... Voir le document complet
47
Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells.
... prognosis and chromosome stabil- ity ...tumor and inversely with portal vein tumor thrombi [23]. In addi- tion, -catenin mutations were associated with signifi- cantly better 5-year patient survival ... Voir le document complet
21
NOTCH, a new signaling pathway implicated in holoprosencephaly.
... haploinsufficiency in adult mice leads to a reduce body weight (53) Nevertheless no investigations of possible fine structural abnormalities of the forebrain have been ...death and result in ... Voir le document complet
32
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression
... JAK/STAT signaling pathway leads to down modulation of Foxp3 in ...hour in complete medium alone ...gated in CD4 + cells and are representative of 4 independent ...or in ... Voir le document complet
17
Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML
... response in patients with acute myeloid leukemia (AML), but these responses are almost always ...resistant AML cell lines by sustained treatment with the FLT3 inhibitor ...mutation and are ... Voir le document complet
14
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway
... fluctuations in intracellular phosphorylation events after the perturbation of signaling ...dynamics, and studies have successfully applied this to T cells (34, ...changes in phosphorylation ... Voir le document complet
31
Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
... ZEB1 and ZEB2, and by stabilizing IL11 mRNA, thus favoring tumor cell dissemination [ 88 ...TGFβ signaling and miRNA in modulating EMT has been investigated in samples from ... Voir le document complet
18
The Notch signaling pathway involvement in innate lymphoid cell biology
... Notch signaling pathway Notch signaling was first defined in the context of cell fate decisions during Drosophila melanogaster development [ 13 ...Notch signaling pathway is more ... Voir le document complet
12
Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling
... RNA-sequencing and Bioinformatic Analyses Following total RNA isolation from FAC sorted GFP-positive cells using Rneasy Plus Kit (Qiagen), RNA was quality controlled and quantified using an Agilent ... Voir le document complet
33
The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway *
... WNT5A-PTK7-JNK pathway to cell move- ...wound in 8 h, whereas addition of WNT5A led to an almost (90%) complete closure ...3E). In contrast, PTK7-deficient MEFs were not responsive to WNT5A ... Voir le document complet
13
View of Diagnostic Utility of Creatine Kinase in Patients Presenting to the Emergency Department with Chest Pain
... (NSTEMI), and ST- Elevated Myocardial Infarction ...(ECG) and UA is diagnosed clinically in absence of elevated cardiac ...rise and/or fall in cardiac troponin (cTn) with at least one ... Voir le document complet
4
Lamin-Related Congenital Muscular Dystrophy Alters Mechanical Signaling and Skeletal Muscle Growth
... implementing in vitro experi- mentation, we demonstrate that fusion defects exist in LMNA-CMD cells and may be due to aberrant adherens junction ...cadherins and catenins [ 46 – 49 ]. ... Voir le document complet
22
Cross talk between fanconi anemia and unc5a signaling pathway
... instance, in tissue ...damage signaling, oxygen radical metabolism, signal transduction, transcriptional regulation and ...UNC5A and to delay UNC5A-mediated ...Netrin-1 and mediates a ... Voir le document complet
141
Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest.: Syk activates p53 signaling pathway
... level). In this setting as well, elevated expression of Syk led to inhibition of colony ...re-expression in melanoma cells and we found that level of exogenous Syk in lysates made from ... Voir le document complet
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