Top PDF Controlling senescence by PML and PML nuclear bodies

Controlling senescence by PML and PML nuclear bodies

Controlling senescence by PML and PML nuclear bodies

... organisms and cells are under constant stress causing the accumulation of mutations, adducts and other detrimental alterations to the genetic code and potentially harmful ...tumors and ...

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Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis

Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis

... HA-UBN1 by transduction of BJ cells with lentiviral- vectors ( S2 Fig ...38.5˚C and har- vested 24 hpi to perform ChIP-qPCR on multiple loci spread over the entire HSV-1 genome, representing promoter or ...

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PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx

PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx

... Abstract PML (Promyelocytic Leukemia protein), also known as TRIM19, belongs to the family of tri- partite motif (TRIM) ...proteins. PML is mainly expressed in the nucleus, where it forms dynamic structures ...

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Around and beyond 53BP1 nuclear bodies

Around and beyond 53BP1 nuclear bodies

... similar nuclear domains containing 53BP1 have been described to indicate other type of genotoxic ...53BP1-related bodies have been observed in the context of delayed or arrested cellular ...during ...

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Exploring Mammalian Genome within Phase-Separated Nuclear Bodies: Experimental Methods and Implications for Gene Expression

Exploring Mammalian Genome within Phase-Separated Nuclear Bodies: Experimental Methods and Implications for Gene Expression

... compartments by phase separation appears to be a powerful mechanism for nuclear compartmentalization that could drive inter-TADs interactions between distant specific genomic ...dense and the dilute ...

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Les isoformes de PML et la réponse au TGF-β

Les isoformes de PML et la réponse au TGF-β

... SUMMARY PML isoforms and TGF-b response PML/TRIM19 is the organizer of PML nuclear bodies (NB), a multi- protein complex associated to the nuclear matrix, which recruit a ...

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Antisense protein of HTLV-2 (APH-2) associates with PML nuclear bodies: molecular determinants and functional implications

Antisense protein of HTLV-2 (APH-2) associates with PML nuclear bodies: molecular determinants and functional implications

... HTLV and Related Viruses Montreal, ...similarities and/or differences between APH-2 and the antisens protein of HTLV-1, ...discrete nuclear domains distinct from ...localization and to ...

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PML nuclear bodies and chromatin dynamics: catch me if you can!

PML nuclear bodies and chromatin dynamics: catch me if you can!

... of PML and organization of PML NBs. (A) Structure of the PML protein ...All PML isoforms (I–VII), ranging from 882aa (PML-I) to 435aa (PML-VII), possess a conserved RBCC ...

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en fr Identification of new regulators for PML nuclear bodies Identification de nouveaux régulateurs des corps nucléaires PML

... morbidity and mortality worldwide and in addition are predicted to increase in number (Stewart & Wild ...caused by the malignant proliferation of cells derived from bone ...hematopoiesis ...

198

Creating Weyl nodes and controlling their energy by magnetization rotation

Creating Weyl nodes and controlling their energy by magnetization rotation

... electric and thermoelectric performance in the regimes of both linear [ 2 – 5 ] and nonlinear [ 6 , 7 ] ...momentum and energy [ 8 – 10 ...magnetism and topology, one that does not rely on the ...

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Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

... Youmna Kfoury 1 , Niclas Setterblad 2 , Marwan El-Sabban 3 , Alessia Zamborlini 4 , Zeina Dassouki 1 , Hiba El Hajj 1 , Olivier Hermine 5 , Claudine Pique 6 , Hugues de Thé 4 , Ali Saïb 4 , Ali Bazarbachi 1* From 15th ...

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General molecular biology and architecture of nuclear receptors.: Transcriptional regulation by nuclear receptors

General molecular biology and architecture of nuclear receptors.: Transcriptional regulation by nuclear receptors

... yeast and subsequently characterized in other eukaryotic ...TFIIH) and elongation factors, Mediator plays a key role in RNA polymerase II-controlled transcription [201] ...modules and includes more ...

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Controlling evolution by means of machine learning

Controlling evolution by means of machine learning

... proceeds by exploring the training examples either in a top-down or in a bottom-up ...trees by repeatedly selecting the most discriminant genes, ...example and nds out the rules that generalize this ...

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Bodies of information : reinventing bodies and practice in medical education

Bodies of information : reinventing bodies and practice in medical education

... This dissertation recounts the development of graphic models of human bodies and virtual reality simulators for teaching anatomy and surgery to medical students, residents, and physician[r] ...

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Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.

Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.

... controlled by AMP-responsive protein kinase (AMPK), which functions as a sensor for cellular nutrient and energy ...activation and thereby induce autophagy (Hay ...

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Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies.

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies.

... [7], and TJP1 exon 20 inclusion is repressed by hnRNP L [21], we exam- ined the effect of both Sam68 and hnRNP L protein expression on these known target exons (Figure ...2 and 3). Together, ...

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Controlling G-AIMD by Index Policy

Controlling G-AIMD by Index Policy

... MIMD and outline the computational procedure for the ...show by numerical experiments for AIMD that the index policy significantly outperforms the natural heuristic that upon congestion reduces the ...

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Controlling processing consistency, quality and efficiency by predictive modeling of meat by-products transformation

Controlling processing consistency, quality and efficiency by predictive modeling of meat by-products transformation

... scraps and leg bones, and that protein extraction kept following a linear trend after 2h at 90°C and 110°C (even though temperature was kept constant past this point) led us to believe that this was ...

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Advances in melanoma senescence and potential clinical application

Advances in melanoma senescence and potential clinical application

... of senescence checkpoints allows continued proliferation and sustained DNA damage leading to genetic instability and cancer ...genetic and epigenetic changes in melanoma is associated with the ...

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Controlling crackling dynamics by triggering low-intensity avalanches

Controlling crackling dynamics by triggering low-intensity avalanches

... statistics and considerably limit the magnitude of the largest ...extent, and frequency govern the ...ruled by a single reduced parameter, namely the injected power per unit front length; the ...

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