[PDF] Top 20 Context is everything: aneuploidy in cancer

... Context is everything: aneuploidy in cancer The MIT Faculty has made this article openly ..."Context is everything: aneuploidy in ... Voir le document complet

... response in humans as well as in animals ...increase in their number is a factor of poor prognosis in patients with ovarian cancer ...system is seen added to all these ... Voir le document complet

... Keywords: aneuploidy, autophagy, cancer, proteotoxicity, TFEB Abstract Aneuploidy, defined as an alteration in chromosome number that is not a multiple of the haploid complement, ... Voir le document complet

... work in yeast, we proposed that imbalances in cellular protein composition lead to a response that is not unlike a stress response, where pathways are activated that shield cells from the adverse ... Voir le document complet

... of cancer clusters relies on increased production of angiogenesis stimulators, such as vascular endothelial growth factor (VEGF), that attract nutrient and oxygen providing blood vessels to the growing tumors ... Voir le document complet

... exchange is the co- infection of the insect vector by two distinct parasite ...'strains' is rare [46], this would imply that the vector successively feeds on two hosts infected with different 'strains', an ... Voir le document complet

... However, knockdown of CHD8 in gastric cancer cell lines by RNAi resulted in increased proliferation, suggesting that there could in fact be selective pressure for CHD8 los[r] ... Voir le document complet

... variability is a hallmark of diseases involving chromosome gains and losses, such as Down Syndrome and ...defined aneuploidy exhibit heterogeneity in cell cycle progression and response to ... Voir le document complet

... Introduction In all living organisms, cells arise from the division of a pre-existing cell and inherit one copy of the genome identical to that of the mother ...defect in chromosome segregation can lead to ... Voir le document complet

... (PAC) is a leading cause of cancer-related mortality in western countries and is predicted to become the second leading cause of cancer death in ...symptoms is that 80% of ... Voir le document complet

... helpful in quickly resolving their problems [ 73 , 74 ...included in cancer clinical trials and the ...that is currently being evaluated by stakeholders, including the Food and Drug ... Voir le document complet

... helpful in quickly resolving their problems [ 73 , 74 ...included in cancer clinical trials and the ...that is currently being evaluated by stakeholders, including the Food and Drug ... Voir le document complet

... to cancer, autosomal aneuploidy has been associated with numerous human conditions that result in impaired ...development. In humans, three viable trisomies have been ...affected in ... Voir le document complet

... reduction in free amino acids could be the trigger ...generated in aneu- ploid cells and under conditions of continuous protea- some inhibition, autophagosomal content accumulates in the lysosomal ... Voir le document complet

... higher in cancer compared to normal tissues, and this increase correlated with increased grade, BMI1 must be contributing to cancer ...it is also possible that BMI1 is a tumor ... Voir le document complet

... profiling is necessary or whether prognostication based on aneuploidy could also be performed with a limited panel of genes, we evaluated the difference in median expressions between the most ... Voir le document complet

... [Keywords: aneuploidy; chromosomal instability; hematopoiesis; single-cell sequencing; population flush hypothesis] Supplemental material is available for this ...accepted in revised form May 27, ... Voir le document complet

... point is under investigation in a clinical study that evaluates whether breast cancers with high chromosomal instability (CIN) may respond better to taxane-based chemotherapy than low-CIN cancers ...target ... Voir le document complet

... Abstract Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative ...which aneuploidy could contribute to tumorigenesis, we examined ... Voir le document complet

... social class affect conceptions of the self and also pattern of thinking, feeling, and acting (see for example, Snibbe & Markus, 2005). Because compensation concerns the evaluative reaction of groups to asymmetrical ... Voir le document complet