[PDF] Top 20 Constructing ensembles for intrinsically disordered proteins
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Constructing ensembles for intrinsically disordered proteins
... others. For example, while data obtained from PRE experiments are useful for estimating average inter-residue distances in an ensemble, it is important to note that in order to obtain these data one must ... Voir le document complet
12
NMR methods for intrinsically disordered proteins : application to studies of NS5A protein of hepatitis C virus
... mechanism for folding upon binding and induced fit sce- ...transition Intrinsically disordered proteins are far from being random ...required for interactions of this kind of ...cases ... Voir le document complet
259
Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist
... effector proteins secreted by ...two proteins in infected cells show that only one of the repeats is essential for the activation of ...scaffold proteins to bind MAPKs at the KIM or D-motif ... Voir le document complet
12
An intrinsically disordered region of OSBP controls membrane contact site geometry and dynamics
... RELATED PROTEINS OSBP was identified in 1980s in experiments performed to elucidate mechanisms of sterol synthesis regulation in cultured ...affinitity for different oxysterols correlated with their ability ... Voir le document complet
256
Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma
... mainly disordered within the NMR time scale even after the binding occurs, and the effects observed in the thermal denaturation experiments must be local and restricted to particular polypeptide ...data for ... Voir le document complet
16
Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B
... both proteins by using spectroscopic (namely, fluorescence, NMR, and CD) and biochemical (proteolysis degra- dation) ...these proteins both in cellulo and in vitro, with an affinity of ∼10 ...remained ... Voir le document complet
11
Dissociation of the Dimer of the Intrinsically Disordered Domain of RNase Y upon Antibody Binding
... essential for cell viability, the crucial role of RNase Y in initiating mRNA cleavage is highlighted by deletion experiments of the rny gene, which led to defects in cell growth, cell morphology and ... Voir le document complet
46
Dissociation of the dimer of the intrinsically disordered domain of RNase Y upon antibody binding
... essential for cell viability, the crucial role of RNase Y in initiating mRNA cleavage is highlighted by deletion experiments of the rny gene, which led to defects in cell growth, cell morphology and ... Voir le document complet
46
A Unified Description of Intrinsically Disordered Protein Dynamics under Physiological Conditions Using NMR Spectroscopy
... following day, selected oocytes were placed in a small petri dish containing a grid for injection. Oocytes were oriented with the animal pole upward for injection of labelled proteins in this pole. ... Voir le document complet
31
Comparative Studies of Disordered Proteins with Similar Sequences: Application to Aβ40 and Aβ42
... strategy for retarding the formation of A b fibrils ( 61 ...equation for the posterior probability distribution is conditioned on the choice of structures, it is conceivable that a poor choice of structural ... Voir le document complet
11
Intrinsically disordered regions may lower the hydration free energy in proteins: a case study of nudix hydrolase in the bacterium Deinococcus radiodurans.
... used for calculating hydration free ...relevant for the C-terminal tail as its sequence exhibits lower levels of intrinsic disorder than the N- terminal ...globular proteins from our representative ... Voir le document complet
11
Investigation of Intrinsically Disordered Proteins through Exchange with Hyperpolarized Water
... achieved for OPN were about 40 for the overall spectrum and 58 for the most intense peaks with respect to thermal ...6088C for denatured Trypsin (247 amino acids, like ...aim for ... Voir le document complet
5
Small-angle scattering studies of intrinsically disordered proteins and their complexes
... descriptions for entities that probe an astronomical number of conformations, and the statistical significance of ensembles derived from data containing a very limited amount of ...search for the ... Voir le document complet
22
Realistic Ensemble Models of Intrinsically Disordered Proteins Using a Structure-Encoding Coil Database
... Abstract Intrinsically Disordered Proteins (IDPs) play fundamental roles in signaling, reg- ulation and cell homeostasis by specifically interacting with their ...calls for the consideration ... Voir le document complet
36
Constructing Symbolic Representations for High-Level Planning
... procedure for constructing operator descrip- tions given in this section uses only propositions enumerated above, it follows that P is sufficient for describing the sys- ...|c) for the ... Voir le document complet
10
A Generic Environment for Constructing Diagnostic Hierarchies
... Blocking (Blocages): 1. Wood built into a roofing system above the deck and below the membrane and flashing to (a) stiffen the deck around an opening, (b) act as a stop for insulation, (c) serve as a nailer ... Voir le document complet
92
Ensembles
... Donner l’ensemble des cases de T sous forme ´etendue (on repr´esentera chaque case par ses coordonn´ees). 2.[r] ... Voir le document complet
2
De-[Constructing] Growth
... Sustainability 2016, 8, 1140 3 of 3 consumption. The key is to de-couple profit-taking, not eliminate profit-taking, from unsustainable production and services. By a judicious choice of policy interventions, society may ... Voir le document complet
3
Ensembles
... Dans une universit´e de langues, 100 des 120 ´etudiants inscrits en premi`eres ann´ee ap- prennent au moins une langue ´etrang`ere, parmi l’anglais, l’italien et l’espagnol.. Le d´eparte[r] ... Voir le document complet
3
Computational Amide I Spectroscopy from the ground up : building and benchmarking new tools to study disordered peptide ensembles
... structure through the use of site-specific isotope labeling. 2 3 The structural utility of this approach stems from the acute sensitivity of Amide I vibrational frequenc[r] ... Voir le document complet
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